Swept-source optical coherence tomography features of regressed macular retinoblastoma

Damodaran, Sourav; Bajaj, Mandeep S; Sharma, Pradeep; Kumar, Atul; Chawla, Rohan; Pujari, Amar; Garg, Gaurav; Temkar, Shreyas

doi:10.4103/ijo.ijo_533_19

Cited by 4 publications

(2 citation statements)

References 25 publications

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“…The resolution of subretinal fluid and maculopathy following chemotherapy can be precisely detected [ 151 ]. With the advances in SS-OCT technology that enabled a deeper penetration into the tumor, Damodaran et al described three different regression patterns of Rb [ 152 ]. This allows for better follow-up of Rb in order to detect early recurrences.…”

Section: Oct and Octa In Neoplasmmentioning

confidence: 99%

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

et al. 2023

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Indirect ophthalmoscopy and handheld retinal imaging are the most common and traditional modalities for the evaluation and documentation of the pediatric fundus, especially for pre-verbal children. Optical coherence tomography (OCT) allows for in vivo visualization that resembles histology, and optical coherence tomography angiography (OCTA) allows for non-invasive depth-resolved imaging of the retinal vasculature. Both OCT and OCTA were extensively used and studied in adults, but not in children. The advent of prototype handheld OCT and OCTA have allowed for detailed imaging in younger infants and even neonates in the neonatal care intensive unit with retinopathy of prematurity (ROP). In this review, we discuss the use of OCTA and OCTA in various pediatric retinal diseases, including ROP, familial exudative vitreoretinopathy (FEVR), Coats disease and other less common diseases. For example, handheld portable OCT was shown to detect subclinical macular edema and incomplete foveal development in ROP, as well as subretinal exudation and fibrosis in Coats disease. Some challenges in the pediatric age group include the lack of a normative database and the difficulty in image registration for longitudinal comparison. We believe that technological improvements in the use of OCT and OCTA will improve our understanding and care of pediatric retina patients in the future.

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Section: Oct and Octa In Neoplasmmentioning

confidence: 99%

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

et al. 2023

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“…Although surgery combined with radiotherapy and chemotherapy has made some progress, the therapeutic effect and prognosis of retinoblastoma are still unsatisfactory. 4 , 5 We believe that this is mainly due to delayed diagnosis and high incidence of tumor metastasis. 6 , 7 Therefore, we urgently need to explore the relevant mechanisms of retinoblastoma and provide effective therapeutic schemes.…”

Section: Introductionmentioning

confidence: 99%

LncRNA NEAT1 Acts as an miR-148b-3p Sponge to Regulate ROCK1 Inhibition of Retinoblastoma Growth

Lü¹,

Zhang²,

Lu³

et al. 2021

CMAR

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Background: It is reported that long non-coding RNA nuclear paraspeckle assembly transcript 1 (LncRNA NEAT1) is involved in the occurrence and development of various cancers. However, the detailed biological function and mechanism of LncRNA NEAT1 in retinoblastoma are still unclear. So we will explore the biological function and possible mechanism of LncRNA NEAT1 in retinoblastoma. Materials and Methods: Quantitative real-time PCR (qRT-PCR) was used to detect LncRNA NEAT1 in retinoblastoma tissues and cell lines. Cell counting kit 8, Transwell and flow cytometry were applied to explore cell proliferation, invasion and apoptosis. The target miRNAs (miR) of LncRNA NEAT1 and miR and downstream target genes were predicted using Starbase3.0 software and confirmed by double luciferase reporting test and RNA binding protein immunoprecipitation (RIP). Western Blot was applied to explore ROCK1 in cells, and tumor allogeneic experiment was applied to study the role of LncRNA NEAT1 on tumor growth. Results: It was found that LncRNA NEAT1 was up-regulated in retinoblastoma tissues, cells and serum, and the prognosis of patients with high expression of LNC RNA NEAT 1 was poor. Functional analysis showed that knocking down LncRNA NEAT1 could weaken proliferation and invasion, and accelerate apoptosis. Tumor allogeneic experiment showed that sh-NEAT1 injection can inhibit tumor growth. In addition, LncRNA NEAT1 inhibited proliferation and invasion, and promoted apoptosis through miR-148b-3p/ROCK1 axis. Conclusion: LncRNA NEAT1 can mediate miR-148b-3p/ROCK1 axis to weaken the proliferation and invasion of retinoblastoma.

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Retinoblastoma and Simulating Lesions

Yanoff,

Sassani

2025

Ocular Pathology

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Swept-source optical coherence tomography features of regressed macular retinoblastoma

Cited by 4 publications

References 25 publications

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

Optical Coherence Tomography and Optical Coherence Tomography Angiography in Pediatric Retinal Diseases

LncRNA NEAT1 Acts as an miR-148b-3p Sponge to Regulate ROCK1 Inhibition of Retinoblastoma Growth

Retinoblastoma and Simulating Lesions

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