Swept-Source OCT Angiography of Macular Telangiectasia Type 2

Thorell, Mariana Rossi; Zhang, Qinqin; Huang, Y. P.; An, Lin; Durbin, Mary K; Laron, Michal; Sharma, Utkarsh; Stetson, Paul F.; Gregori, Giovanni; Wang, Ke; Rosenfeld, Philip J.

doi:10.3928/23258160-20140909-06

Cited by 106 publications

(86 citation statements)

References 41 publications

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“…OMAG employs a differential operation based on complex OCT signals to utilize both intensity and phase information available in the system; hence it is a complex-based OCTA technique. In the past several years, OMAG has been successful in identifying disorder or dysfunction in the retinal and choroidal microvascular networks in vivo [18][19][20]. Despite many promising results of ocular blood flow using OMAG, the quantitative relationship between OMAG and flow remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Characterizing relationship between optical microangiography signals and capillary flow using microfluidic channels

Choi

Wan

Chen

et al. 2016

Biomed. Opt. Express

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Optical microangiography (OMAG) is a powerful optical angiographic tool to visualize micro-vascular flow in vivo. Despite numerous demonstrations for the past several years of the qualitative relationship between OMAG and flow, no convincing quantitative relationship has been proven. In this paper, we attempt to quantitatively correlate the OMAG signal with flow. Specifically, we develop a simplified analytical model of the complex OMAG, suggesting that the OMAG signal is a product of the number of particles in an imaging voxel and the decorrelation of OCT (optical coherence tomography) signal, determined by flow velocity, interframe time interval, and wavelength of the light source. Numerical simulation with the proposed model reveals that if the OCT amplitudes are correlated, the OMAG signal is related to a total number of particles across the imaging voxel cross-section per unit time (flux); otherwise it would be saturated but its strength is proportional to the number of particles in the imaging voxel (concentration). The relationship is validated using microfluidic flow phantoms with various preset flow metrics. This work suggests OMAG is a promising quantitative tool for the assessment of vascular flow. Chen, and R. K. Wang, "Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography," J. Biomed. Opt. 21(6), 065002 (2016). 42. Z. Chu, J. Lin, C. Gao, C. Xin, Q. Zhang, C. L. Chen, L. Roisman, G. Gregori, P. J. Rosenfeld, and R. K. Wang, "Quantitative assessment of the retinal microvasculature using optical coherence tomography angiography," J.

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Section: Introductionmentioning

confidence: 99%

Characterizing relationship between optical microangiography signals and capillary flow using microfluidic channels

Choi

Wan

Chen

et al. 2016

Biomed. Opt. Express

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“…We developed a novel optical microangiography (OMAG) imaging technique based on Fourier-domain optical coherence tomography (FD-OCT), which is capable of non-invasive threedimensional (3D) in vivo microcirculatory visualization in the eye with microscopic resolution (8). It has been used successfully to identify retinal capillaries and areas of neovascularization in macular telangiectasia type 2 (9). The purpose of this study was to use OMAG to visualize, quantify, and compare ONH perfusion in healthy and glaucomatous eyes.…”

Section: Introductionmentioning

confidence: 99%

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Chen¹,

Bojikian²,

Gupta³

et al. 2016

Quant. Imaging Med. Surg.

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Background: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.Methods: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. En face OMAG images for preLC were generated using signals with highest blood flow signal intensity. ONH Results: Twenty normal and 21 glaucoma subjects were enrolled. Glaucomatous eyes had significantly lower ONH perfusion in preLC in all three perfusion metrics compared to normal eyes (P≤0.0003).Significant correlations between ONH perfusion and disease severity as well as structural changes were detected in glaucomatous eyes (P≤0.012).Conclusions: ONH perfusion detected by OMAG showed significant differences between glaucoma and normal controls and was significantly correlated with disease severity and structural defects in glaucomatous eyes. ONH perfusion measurement using OMAG may provide useful information for detection and monitoring of glaucoma.

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“…The method can be applied to various retinal diseases, among these frequently occurring retinal diseases such as diabetic retinopathy (DR) and the neovascular type of age-related macular degeneration (AMD). Due to its relatively simple implementation into OCT devices (only the scanning pattern and the data evaluation have to be modified) many manufactures of retinal OCT devices have updated their devices and OCTA has shown a high impact in the field of retinal imaging [11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

Salas

Augustin

Ginner

et al. 2016

Biomed. Opt. Express

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Abstract:The purpose of this work is to investigate the benefits of adaptive optics (AO) technology for optical coherence tomography angiography (OCTA). OCTA has shown great potential in non-invasively enhancing the contrast of vessels and small capillaries. Especially the capability of the technique to visualize capillaries with a lateral extension that is below the transverse resolution of the system opens unique opportunities in diagnosing retinal vascular diseases. However, there are some limitations of this technology such as shadowing and projection artifacts caused by overlying vasculature or the inability to determine the true extension of a vessel. Thus, the evaluation of the vascular structure and density based on OCTA alone can be misleading. In this paper we compare the performance of AO-OCT, AO-OCTA and OCTA for imaging retinal vasculature. The improved transverse resolution and the reduced depth of focus of AO-OCT and AO-OCTA greatly reduce shadowing artifacts allowing for a better differentiation and segmentation of different vasculature layers of the inner retina. The comparison is done on images recorded in healthy volunteers and in diabetic patients with distinct pathologies of the retinal microvasculature.

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Swept-Source OCT Angiography of Macular Telangiectasia Type 2

Cited by 106 publications

References 41 publications

Characterizing relationship between optical microangiography signals and capillary flow using microfluidic channels

Characterizing relationship between optical microangiography signals and capillary flow using microfluidic channels

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Visualization of micro-capillaries using optical coherence tomography angiography with and without adaptive optics

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