Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos

Abroug, Nesrine; Ksiaa, Imen; Lupidi, Marco; Nabi, Wejdene; Attia, S.; Jelliti, Béchir; Khochtali, Sana; Khairallah, Moncef

doi:10.1007/s10792-019-01115-7

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…The SD-OCT-A findings in the present study are contrary to those described by Abroug et al 10 In that study, the capillary vessel densities were found to be significantly lower in both superficial and deep capillary plexuses at the foveal region.…”

Section: Sd-oct-a Layercontrasting

confidence: 99%

“…A literature review revealed only one study which recently described swept-source OCT-A findings in eyes with PM. 10 In the present study, there was a documented increase in the capillary vessel densities in both superficial and deep capillary plexuses at the foveal region and a decrease in vessel density in the deep capillary plexus at the parafoveal region.…”

Section: Sd-oct-a Layersupporting

confidence: 60%

“…Recently, newer imaging modalities such as swept-source OCT and swept-source OCTangiography (OCT-A) have been used to describe the structural and vascular changes seen in PM. 10 Multicolour scanning laser imaging is a recently introduced innovative technology developed for Spectralis SD-OCT (Heidelberg Engineering, Heidelberg, Germany). It has been widely used to describe the findings in various retinal and choroidal pathologies.…”

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confidence: 99%

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Retinal structural and vascular changes in posterior microphthalmos

Venkatesh

Jain

Srinivasan

et al. 2020

Clinical and Experimental Optometry

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Background Posterior microphthalmos (PM) is a rare developmental disorder characterised by high hyperopia, short axial length, presence of retinal papillomacular fold and relatively normal anterior segment findings. The study objective is to describe the retinal structural and vascular changes in eyes with PM with spectral domain optical coherence tomography, optical coherence tomography angiography and multicolour imaging. Methods In this retrospective, comparative case series, 10 eyes of five patients with PM as cases and 10 eyes of five age‐ and sex‐matched controls were included. Structural changes, namely inner and outer retinal layer thicknesses, were measured using optical coherence tomography. Multicolour imaging findings were noted. Perifoveal vascular changes with qualitative and quantitative assessments were analysed using optical coherence tomography angiography. Results The foveal dip was absent in all 10 eyes (100 per cent) with PM. There was an elevated retinal papillomacular fold in six eyes (60 per cent) and intraretinal cystoid spaces in two eyes (20 per cent) with PM. The inner retinal layers were thicker in PM. On multicolour imaging, foveal avascular zone and retinal wrinkles were identified in eyes with retinal papillomacular fold in blue and green reflectance images. Perifoveal vascular changes in optical coherence tomography angiography included foveal area size reduction in superficial and deep vascular networks. The foveal capillary vessel densities were higher in PM compared to the controls in both superficial (46.3 ± 3.7 per cent; p = 0.000) and deep (54.7 ± 3.5 per cent; p = 0.000) capillary plexuses. Flow areas in superficial (p = 0.693) and deep (p = 0.088) capillary plexuses were not statistically relevant. Conclusion The study suggests that in PM, retinal foreshortening occurs in one meridian leading to secondary changes such as loss of foveal dip, posterior bowing of the outer layers of the eye, thickening of the inner retina and ultimately, retinal papillomacular fold formation. The findings of the study need further validation in a larger series of patients with PM.

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Section: Sd-oct-a Layercontrasting

confidence: 99%

Section: Sd-oct-a Layersupporting

confidence: 60%

mentioning

confidence: 99%

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Retinal structural and vascular changes in posterior microphthalmos

Venkatesh

Jain

Srinivasan

et al. 2020

Clinical and Experimental Optometry

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“…Through the use of OCTA, changes in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), vascular density, and the foveal avascular zone (FAZ) can be assessed. OCTA has been demonstrated to be clinically useful in evaluating numerous retinal and choroidal conditions such as diabetic retinopathy, retinal vascular occlusions (RVOs), macular telangiectasia, choroidal neovascularisation (CNV), and inflammatory conditions [13].…”

Section: Introductionmentioning

confidence: 99%

Changes in Outcomes of Macular Optical Coherence Tomography Angiography Following Surgery for Optic Disc Pit Maculopathy

Akıdan,

Erol,

Gedik

et al. 2024

Diagnostics

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Purpose: we aimed to report on the optical coherence tomography angiography (OCTA) outcomes of eight patients with optic disc pit maculopathy (ODP-M) who were treated with 23-gauge pars plana vitrectomy (PPV). Methods: We examined sixteen eyes of eight patients—eight eyes with ODP-M and eight healthy fellow eyes. Fundus color photography, fundus autofluorescence, fundus fluorescein angiography, optical coherence tomography (OCT), and OCTA were performed. The vascular density, choriocapillaris blood flow (CCBF), and foveal avascular zone (FAZ) were analyzed using OCTA. Moreover, the correlation between the best-corrected visual acuity (BCVA) and macular OCTA parameters was assessed. Results: Compared with the healthy fellow eyes, the eyes with ODP-M preoperatively were found to have decreased BCVA, superficial capillary plexus (SCP) vascular density (i.e., total, foveal, parafoveal, and perifoveal), deep capillary plexus (DCP) vascular density (i.e., total, parafoveal, and perifoveal), and CCBF but a significantly increased FAZ (p < 0.05). When the eyes with ODP-M were analyzed pre- and postoperatively at month 12 after surgery, the BCVA, SCP vascular density (i.e., perifoveal), and CCBF had significantly increased, and the FAZ had significantly decreased (p < 0.05). When the eyes with ODP-M were compared with the healthy fellow eyes postoperatively at month 12, the BCVA, SCP, and DCP vascular density parameters had increased, along with CCBF, and the FAZ had decreased in eyes with ODP-M, though not to the levels of the healthy fellow eyes (p < 0.05). Moreover, a positive correlation was found between the postoperative BCVA and SCP total vascular density (p < 0.05). Conclusion: The BCVA and macular OCTA parameters improved in eyes with ODP-M at month 12 following surgery. However, the BCVA and OCTA of the eyes operated on did not reach the levels of the healthy fellow eyes, possibly due to impaired choroidal blood flow (CBF) recovery and the presence of a larger FAZ. In summary, OCTA seems to be useful for assessing qualitative and quantitative perioperative microvascular changes.

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1045 nm purely gain coupled semiconductor laser based on periodic electric injection

Chen

Lei

et al. 2020

Journal of Luminescence

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Swept source-OCT and swept source-OCT angiography findings in posterior microphthalmos

Cited by 9 publications

References 25 publications

Retinal structural and vascular changes in posterior microphthalmos

Retinal structural and vascular changes in posterior microphthalmos

Changes in Outcomes of Macular Optical Coherence Tomography Angiography Following Surgery for Optic Disc Pit Maculopathy

1045 nm purely gain coupled semiconductor laser based on periodic electric injection

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