Swelling of poly(N-isopropylacrylamide) P(NIPA)-based hydrogels with bacterial-synthesized prodigiosin for localized cancer drug delivery

Danyuo, Y.; Dozie-Nwachukwu, S.; Obayemi, John D.; Ani, C.J.; Odusanya, Olushola S.; Oni, Y.; Anuku, N.; Malatesta, Karen; Soboyejo, W.O.

doi:10.1016/j.msec.2015.09.090

Cited by 26 publications

(19 citation statements)

References 32 publications

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“…The implications of the above results are very significant for the controlled delivery of prodigiosin cancer drug 6,7 to tumor sites 20 . First, they show clearly that there is a need to use the knowledge of the release kinetics to guide the controlled delivery of prodigiosin to be within the therapeutic windows.…”

Section: Discussionmentioning

confidence: 88%

“…1a–d). Prior work has shown that the increased porosity (with increasing AM content) is also associated with increased cross-linking 5–7 . In any case, the porosity of the P(NIPA)-based gels provides pathways for drug diffusion through the P(NIPA)-based structures.…”

Section: Discussionmentioning

confidence: 97%

“…The release kinetics of drugs from P(NIPA) helps in the selection of a copolymer hydrogel with an appropriate LCST that can enhance drug release even at physiological conditions. However, recent work 6 has revealed that their cancer drug release mechanisms are non-Fickian 6,7 . There is, therefore, a need to develop a better understanding of the non-Fickian drug release mechanisms of P(NIPA)-based hydrogels.…”

Section: Introductionmentioning

confidence: 99%

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Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

Danyuo

Ani

Salifu

et al. 2019

Sci Rep

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This paper presents the anomalous release kinetics of a cancer drug (prodigiosin) frompoly-n-isopropyl-acrylamide ( P(NIPA))-based gels. The release exponents, n, which correspond to the drug release mechanisms, were found to be between 0.41 and 1.40. This is within a range that include Fickian case I (n = 0.45) and non-Fickian diffusion (case II) (n > 0.45) for cylindrical drug-loaded structures. The results, however, suggest that the release exponents, n, correspond mostly to anomalous case II and super case II transport mechanics with sigmoidal characteristics. The drug release kinetics of the P(NIPA)-based hydrogels are well described by bi-dose functions. The observed drug release behavour is related to the porosity of the hydrogels, which can be controlled by cross-linking and copolymerization with acrylamide, which also improves the hydrophilicity of the gels. The paper also presents the effects of cancer drug release on cell survival (%), as well as the cell metabolic activities of treated cells and non-treated cells. The implications of the results are discussed for the development of implantable thermosensitive gels for the controlled release of drugs for localized cancer treatment.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

Danyuo

Ani

Salifu

et al. 2019

Sci Rep

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“…The potential application of N -isopropylacrylamide (NIPA) derivatives in controlled release of active pharmaceutical ingredients (API) is presently intensively studied [ 1 ]. Some interesting potential applications include the controlled release of: doxorubicin [ 2 ], mesenchymal stem cells [ 3 ], basic fibroblast growth factor [ 4 ], theophylline [ 5 ], epirubicin [ 6 ], prodigosin [ 7 ], and simvastatin [ 8 ]. The NIPA derivatives may act as “smart” polymers, sensitive to a temperature factor, releasing the API, when the temperature increases locally [ 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…The carboxyl groups may enable ionic binding of cationic drugs [ 5 , 17 ], whereas addition of anionic co-monomer should consequently support binding of acidic APIs. The NIPA derivatives undergo volume phase transition at temperature, which is usually close to the range of human physiological temperatures [ 7 , 18 , 19 , 20 ]. Most of the known volume phase transition temperatures (VPTT) for NIPA derivatives are around 32 °C.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Anionic Initiator on the Selected Properties of Poly-N-Isopropyl Acrylamide Evaluated for Controlled Drug Delivery

2016

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The aim of the study was to monitor the influence of increasing initiator concentrations on the properties of poly-N-isopropylacrylamide (polyNIPA) nanoparticles obtained via surfactant free precipitation polymerization (SFPP). In all studied systems P-001 to P-1, the same amount of monomer was used, and increasing amounts of potassium persulphate (KPS). The course of each reaction was monitored by measuring the conductivity of the whole system. The resulting composition of products was confirmed by attenuated total reflectance within Fourier transformed infrared spectroscopy (ATR-FTIR) measurements. The hydrodynamic diameters with polydispersity index (PDI) and zeta potential (ZP) were measured in aqueous dispersions of the synthesized polymers in dynamic light scattering (DLS) device (λ = 678 nm), and were found to be for P-1: 20.33 nm (PDI = 0.49) and −7 mV, for P-05: 22.24 nm (PDI = 0.39) and −5 mV, for P-01: 50.14 nm (PDI = 0.49) and −3 mV, for P-005: 62.75 nm (PDI = 0.54) and −3 mV and for P-001: 509.4 nm (PDI = 0.61) and −12 mV at 18 °C, respectively. Initiator concentration affects the size and ZP of particles. The hydrodynamic diameter decreases with initiator concentration increase, whereas the time of the reaction decreases when the initiator concentration increases. This fact is reflected in the observed values of conductivity in the course of the performed reaction. Evaluated volume phase transition temperature in the range of 32 °C enables further research of the nanoparticles as thermosensitive drug carriers.

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Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

et al. 2022

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This paper presents the results of an experimental and computational study of the effects of laser‐induced heating provided by magnetite nanocomposite structures that are being developed for the localized hyperthermic treatment of triple‐negative breast cancer. Magnetite nanoparticle‐reinforced polydimethylsiloxane (PDMS) nanocomposites were fabricated with weight percentages of 1%, 5%, and 10% magnetite nanoparticles. The nanocomposites were exposed to incident Near Infrared (NIR) laser beams with well‐controlled powers. The laser‐induced heating is explored in: (i) heating liquid media (deionized water and cell growth media [Leibovitz L15+]) to characterize the photothermal properties of the nanocomposites, (ii) in vitro experiments that explore the effects of localized heating on triple‐negative breast cancer cells, and (iii) experiments in which the laser beams penetrate through chicken tissue to heat up nanocomposite samples embedded at different depths beneath the chicken skin. The resulting plasmonic laser‐induced heating is explained using composite theories and heat transport models. The results show that the laser/nanocomposite interactions decrease the viability of triple‐negative breast cancer cells (MDA‐MB‐231) at temperatures in the hyperthermia domain between 41 and 44°C. Laser irradiation did not cause any observed physical damage to the chicken tissue. The potential in vivo performance of the PDMS nanocomposites was also investigated using computational finite element models of the effects of laser/magnetite nanocomposite interactions on the temperatures and thermal doses experienced by tissues that surround the nanocomposite devices. The implications of the results are then discussed for the development of implantable nanocomposite devices for localized treatment of triple‐negative breast cancer tissue via hyperthermia.

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Swelling of poly(N-isopropylacrylamide) P(NIPA)-based hydrogels with bacterial-synthesized prodigiosin for localized cancer drug delivery

Cited by 26 publications

References 32 publications

Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

The Influence of Anionic Initiator on the Selected Properties of Poly-N-Isopropyl Acrylamide Evaluated for Controlled Drug Delivery

Laser‐induced heating of polydimethylsiloxane‐magnetite nanocomposites for hyperthermic inhibition of triple‐negative breast cancer cell proliferation

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