Swelling degree prediction of polyhydroxybutyrate/chitosan matrices loaded with “Arnica‐do‐Brasil”

Abstract

Polyhydroxybutyrate and chitosan have been studied as materials for drug delivery systems (DDSs) due to their biodegradability and biocompatibility. The aim of this work was to produce amphiphilic polyhydroxybutyrate/chitosan matrices that form porous structures (scaffolds) after swelling in water and arnica extract. The matrices were analyzed by TGA, SEM, XDR, DSC, and FTIR. Thin plate spline interpolation method (TPSIM) was used to predict the swelling of the matrices generating three‐dimensional data fitted, showing the influence of time and concentration variables on both fluids absorption. Polyhydroxybutyrate/chitosan samples containing 60 wt % (weight percent) of chitosan formed a porous structure as they were submitted to arnica loading, and the obtained device was able to deliver arnica in physiological medium. Thus, the produced matrices have a strong potential to perform both as scaffolds and DDS © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47838.

Obtenção De Biodiesel Por Meio Da Transesterificação Do Óleo De Soja Utilizando Catalisador De Koh/Al2 O3 Em Diferentes Composições

“…A polynomial fi t p55, showed in Equation (3), was applied, simultaneously, to the experimental and the interpolated data, to obtain a 3D surface that correlates S W , composition and time [27].…”

Reaproveitamento De Topsoil Como Medida De Recuperação De Áreas Degradadas

“…Fonte não linear 77 G Gestões estratégicas 152 Inspetores Eletrônicos 162,163,168,169,171,172,173 K KAOS 60,61,62,63,64,65,66,67 M Modeling 30,32,34,35,36,37,44,60,61,64,66,67,111,135,136,139 N NASTRAN 13,15,16,19,20,21,22,25,26,27,28,29 O Olaria 174,175,182,183,184,185,186,187 Ontologia 30, 31 Otimização 13,15,16,18,20,21,22,…”

“…Especialmente na reação de transesterificação, os óleos reagem com um álcool de cadeia curta como o metanol ou etanol, na presença de um catalisador que pode ser homogêneo (ácido ou básico), heterogêneo ou enzimático, para produzir os ésteres de alquila (ésteres de ácidos graxos) correspondentes (no caso do metanol, os ésteres metílicos) (Mendonça et al, 2019). Os sistemas heterogêneos não levam à corrosão e nem à formação de emulsões (sabões), tornando o processo de separação mais fácil, o que permite a reciclagem do catalisador sólido ao longo de sua vida útil e minimiza a geração de efluentes (Dantas et al, 2018).…”

“…Interpolation may be used for making prediction [26] and may be a good alternative to predict the effect of materials composition and time in the fluid incorporation studies and the use of TPSIM in polymer swelling behavior has been studied by our research group [27] for polymeric systems as, for example, matrices of polyhydroxybutyrate and chitosan. In this work, it was produced poly (acrylic acid)-starch (PAA-S) films which were loaded with SO.…”

Avaliação Da Prontidão Da Organização De Ait De Satélites Artificiais Para O Atendimento De Requisitos De Seus Stakeholders

“…Democracia energética 47, 51, 52 Desenvolvimento 15,47,52,53,54,55,56,58,60,61,63,64,67,75,98,102,111,112,114,120,122,152,164,178,190,191,192,193,194,196,197 153,156,162 Filmes 113,114,115,116,117,118,119,120,121,122 Flambagem 13,15,18,20,21,24,27,28 Fonte de corrente Howland 77, 89…”