Swelling behavior of polyelectrolyte complex hydrogels composed of chitosan and hyaluronic acid

Kim, Seon Jeong; Lee, Ki Jung; Kim, Sun I.

doi:10.1002/app.20560

Cited by 41 publications

(24 citation statements)

References 25 publications

(14 reference statements)

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“…These results suggest that in the first scaffold the mechanism of water transport is controlled by a Fickian diffusion process, while in the PEC scaffold the rate of water transport responds to a non-Fickian diffusion process, which depends of diffusion and of the macromolecular chain relaxation. Our results are in good agreement with those presented by Kim et al [47] for chitosan-hyaluronic acid polyelectrolyte complexes and by Giers zewska-Dru _ zyń ska et al [48] for chitosan-alginate membranes.…”

Section: Scaffold Stability and Swelling Behaviorsupporting

confidence: 93%

“…The hydrogel swelling mechanism can be interpreted through the two processes, concentration gradient-controlled diffusion and relaxation-controlled swelling; both of them contribute to the rate and extent of penetrant sorption into the polymer [47]. As previously mentioned, to determine the n exponent the kinetics of such process could be analyzed through the Fick model (Eq.…”

Section: Scaffold Stability and Swelling Behaviormentioning

confidence: 99%

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Ultrasonic compatibilization of polyelectrolyte complex based on polysaccharides for biomedical applications

Belluzo

Medina

Cortizo

et al. 2016

Ultrasonics Sonochemistry

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a b s t r a c tIn recent years, there has been an increasing interest in the design of biomaterials for cartilage tissue engineering. This type of materials must meet several requirements. In this study, we apply ultrasound to prepare a compatibilized blend of polyelectrolyte complexes (PEC) based on carboxymethyl cellulose (CMC) and chitosan (CHI), in order to improve stability and mechanical properties through the interpolymer macroradicals coupling produced by sonochemical reaction. We study the kinetic of the sonochemical degradation of each component in order to optimize the experimental conditions for PEC compatibilization. Scaffolds obtained applying this methodology and scaffolds without ultrasound processing were prepared and their morphology (by scanning electron microscopy), polyelectrolyte interactions (by FTIR), stability and mechanical properties were analyzed. The swelling kinetics was studied and interpreted based on the structural differences between the two kinds of scaffolds. In addition we evaluate the possible in vitro cytotoxicity of the scaffolds using macrophage cells in culture. Our results demonstrate that the ultrasound is a very efficient methodology to compatibilize PEC, exhibiting improved properties compared with the simple mixture of the two polysaccharides. The test with murine macrophage RAW 264.7 cells showed no evince of cytotoxicity, suggesting that PEC biomaterials obtained under ultrasound conditions could be useful in the cartilage tissue engineering field.

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Section: Scaffold Stability and Swelling Behaviorsupporting

confidence: 93%

Section: Scaffold Stability and Swelling Behaviormentioning

confidence: 99%

Ultrasonic compatibilization of polyelectrolyte complex based on polysaccharides for biomedical applications

Belluzo

Medina

Cortizo

et al. 2016

Ultrasonics Sonochemistry

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“…65 QCM study of alginate/chitosan coatings on gold coated quartz crystals showed adsorption of various amounts of water depending on environmental humidity. Saturated humidified air caused a decrease of the frequency, whereas the frequency signal was stable in a dry air environment.…”

Section: Resultsmentioning

confidence: 99%

Nanoscale eluting coatings based on alginate/chitosan hydrogels

Peng¹,

Voelcker²,

Kumar³

et al. 2007

Biointerphases

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The localized availability of bioactive biomolecules directly at the implant/tissue interface presents a promising strategy for improved wound healing and thus biointegration. Bioactive molecules that cannot be incorporated into the bulk material of a device may be delivered from a compatible surface coating, while the reservoir capacity of thin surface coatings is limited, they offer localized delivery over the first few critical hours or days of wound healing. In this study an alginate/chitosan hydrogel has been utilized as the basis for nanoscale eluting coatings to provide a hydrophilic yet water insoluble surface delivery system. The release characteristics of these hydrogel coatings were measured by employing the model molecules-fluorescein isothiocyanate dextran ͓FD; molecular weights ͑MWs͒ 4, 70, and 2000 kDa͔, fluorescein isothiocyanate albumin, and rhodamine. Scanning electron microscopy and atomic force microscopy were used to study the morphology of the hydrogel coatings on model substrates, and ellipsometry was employed for measuring the coating thickness. On silicon wafers, the coatings were of good uniformity and conformal, with a thickness of ϳ120 nm and a rms roughness of 3.0 nm. A model porous substrate, paper, which afforded deep pore penetration of the hydrogel, was used to mimic hydroxyapatite. The release of FD was observed to be dependent on the MW, the release medium, charge, and surface roughness. Sustained release was recorded for FD 70 and FD 2000 with yields of about 90% and 75%, respectively, into simulated body fluid within 26 days. Concurrent elution of different molecules from one hydrogel coating was demonstrated. The observed elution profiles were fitted to release kinetics such as the Korsmeyer-Peppas model or first order release.

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“…The rate and extent of penetrant sorption into the polymer are determined by both concentration gradient-controlled and/or relaxation-controlled diffusion [55,56]. The diffusion categories of molecules into polymers when the maximum swelling degree is less or equal to 60 wt% are deducted from the exponent, n , of the following expression (Equation 4) [57–59] …”

Section: Resultsmentioning

confidence: 99%

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

Alghamdi

Alsolami

Saeed

et al. 2018

Designed Monomers and Polymers

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A series of poly(acrylic acid)/poly(methyl vinyl ketone) (PAA/PMVK) blends with different compositions were prepared by the solvent casting method. The miscibility of this pair of polymers was investigated by differential scanning calorimetry(DSC), Fourier transform infra-red (FTIR) and X-Ray diffraction (XRD) techniques. An in-vitro cytotoxicity test of the drug-carrier system via MTT (3-(4,5-demethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay revealed no significant cytotoxic effects at concentrations up to 100 µg· ml−1. The STX/PAA-50 drug carrier systems were also prepared by solvent casting of solutions containing the sulfamethoxazole (STX) used as drug model and PAA/PMVK blend in N.N-dimethylformamide then crosslinked with acidified ethylene glycol. The release dynamic of STX from the prepared hydrogels was investigated in which the diffusion through the polymer matrix, the enhancement of the water solubility of STX, the influence of the initial drug concentration, the pH of the medium, and the effect of the degree of swelling of the polymer matrix on the release dynamic was evaluated. According to the total gastrointestinal transit time estimated by Belzer, the estimate distribution of STX released in the different organs indicated that the performance is obtained with the drug – carrier-system containing equal ratios of polymer and 10 wt% of STX (STX-10/PAA-50).

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Swelling behavior of polyelectrolyte complex hydrogels composed of chitosan and hyaluronic acid

Cited by 41 publications

References 25 publications

Ultrasonic compatibilization of polyelectrolyte complex based on polysaccharides for biomedical applications

Ultrasonic compatibilization of polyelectrolyte complex based on polysaccharides for biomedical applications

Nanoscale eluting coatings based on alginate/chitosan hydrogels

Miscibility of poly(acrylic acid)/poly(methyl vinyl ketone) blend and in vitro application as drug carrier system

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