“…This was due to the disentanglement of interpenetrated polymeric chains, destruction of hydrogen bonding between polymer molecules, and increased chain mobility at a higher temperature, which facilitated network expansion. 18 Such temperature responsiveness was also attributed to the high porosity of the SPH-IPNs because more pores would enhance the uptake of water during swelling in comparison with less porous hydrogels. 19 Salt-sensitive Figure 2 shows that an increase in the ionic strength within the range of 0.001-1M yields a significant decrease in the swelling ratio of SPH-IPN 144 .…”
The swelling of a superporous hydrogel containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks (SPH-IPN) was sensitive toward the pH, ionic strength, and temperature stimuli. With insulin as a model drug, polymerprotein interaction was detected, and it was physical rather than covalent. Freezing water was the majority of the imbibed water in the swollen SPH-IPNs, and the waterretention ability of the polymer against compression and time of exposure at 378C was improved as the amount of the O-carboxymethyl chitosan network increased. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay on AD293 and RBL-2H3 cells and an in situ lactate dehydrogenase assay and morphological study on rat intestine confirmed that the SPH-IPNs had satisfactory biocompatibility. These pronounced properties suggested that the SPH-IPNs could be developed as an attractive peroral delivery vehicle for peptide and protein drugs.
“…This was due to the disentanglement of interpenetrated polymeric chains, destruction of hydrogen bonding between polymer molecules, and increased chain mobility at a higher temperature, which facilitated network expansion. 18 Such temperature responsiveness was also attributed to the high porosity of the SPH-IPNs because more pores would enhance the uptake of water during swelling in comparison with less porous hydrogels. 19 Salt-sensitive Figure 2 shows that an increase in the ionic strength within the range of 0.001-1M yields a significant decrease in the swelling ratio of SPH-IPN 144 .…”
The swelling of a superporous hydrogel containing poly(acrylic acid-co-acrylamide)/O-carboxymethyl chitosan interpenetrating polymer networks (SPH-IPN) was sensitive toward the pH, ionic strength, and temperature stimuli. With insulin as a model drug, polymerprotein interaction was detected, and it was physical rather than covalent. Freezing water was the majority of the imbibed water in the swollen SPH-IPNs, and the waterretention ability of the polymer against compression and time of exposure at 378C was improved as the amount of the O-carboxymethyl chitosan network increased. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay on AD293 and RBL-2H3 cells and an in situ lactate dehydrogenase assay and morphological study on rat intestine confirmed that the SPH-IPNs had satisfactory biocompatibility. These pronounced properties suggested that the SPH-IPNs could be developed as an attractive peroral delivery vehicle for peptide and protein drugs.
“…Formation of hydrogel of 1 (9.0 mm) proceeded in the presence of sodium octyl sulfate (5) in the concentration range 20-30 mm (samples 9-11). Sodium decyl sulfate (6) solutions showed similar behavior to SDS (2), with 0.25-5.0 mm solutions giving hydrogels with 9.0 mm of 1 (samples [12][13][14][15][16]. Sodium tetradecyl sulfate (7) solutions only formed hydrogels of 1 (9.0 mm) at low concentrations (0.10-1.0 mm; samples [17][18][19][20].…”
Section: Ionic Surfactants Induce Amphiphilic Trisa C H T U N G T R Ementioning
confidence: 99%
“…[10] Many studies on the effects of surfactants on polymer gels have been reported, and it is clear that electrostatic and hydrophobic interactions influence their swelling and shrinking. [11][12][13][14][15][16] However, studies on the effects of surfactants on the formation of supramolecular gels are limited. [17,18] We recently developed amphiphilic trisA C H T U N G T R E N N U N G (urea) LMWHGs.…”
Section: Ionic Surfactants Induce Amphiphilic Trisa C H T U N G T R Ementioning
All bundled up: A tris(urea)benzene hydrogelator first self‐assembles into fibrous aggregates, which come together to form bundles (see scheme). The bundling process can be controlled by the concentration of ionic surfactant additive. The right concentration leads to supramolecular hydrogel formation.
“…Therefore, NP-10s may crosslink those uncrosslinked linear polymers acting as a physical crosslinker, which results in the decrease of SAP solubility and avoids the washing process after polymerization. Different from the former studies focusing on the absorption property between the linear polymers/hydrogel and the surfactant micelles [12][13][14][15][16][17], the effects of the surfactant micelles on the SAP synthesis were investigated in the present article for the first time. Especially, it is founded that the concentration of NP-10 put a great effect on the SAP swelling ratio when it was introduced in the polymerization system.…”
A novel superabsorbent polymer (SAP), acrylic acidsodium acrylate/polyoxyethylene (10) nonyl phenyl ether (AA-NaAA/NP), was synthesized with ammonium persulfate (APS) as the initiator and N,N 0 -methylene bisacrylamide (MBA) as the crosslinker. The effects of the polyoxyethylene (10) nonyl phenyl ether (NP-10) concentration on the properties of the SAP reaction solution were investigated. A hypothesis that the NP-10 micelles effect on the polymer configuration was raised. A series of formulas were deduced to describe the hypothesis and the effect of NP-10 concentration on the SAP swelling ratio. When the SAP was crosslinked by NP-10 with m(MBA)/m(AA) 0.030% and by NP-10 with m(MBA)/m(AA) 0.045%, the correlation coefficients of experimental results fitted by the deduced formulas were 0.9541 and 0.9547, respectively.
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