Swelling and protein absorption/desorption of thermo-sensitive lactitol-based polyether polyol hydrogels

Chacón, D.; Hsieh, You‐Lo; Kurth, Mark J.; Krochta, John M.

doi:10.1016/s0032-3861(00)00208-1

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…Under acidic pH values, most of the carboxylate anions are protonated, so the main anion-anion repulsive forces are eliminated and consequently swelling values are decreased. At higher pH values (5)(6)(7)(8), some of the carboxylate groups are ionized and the electrostatic repulsion between COOgroups causes an enhancement of the swelling capacity. Again, a charge screening effects of the counterions (cations) Fig.…”

Section: Effect Of Ph On Swellingmentioning

confidence: 99%

“…These responsive hydrogels have become an important area of research and development in the field of medicine, pharmacy, and biotechnology [2][3][4]. Most hydrogels are formed by copolymerization of vinyl monomers containing hydrophilic side groups with multifunctional vinyl monomers or by crosslinking reactive functional groups of hydrophilic polymers [5]. By manipulating the chemistry of the hydrophilic segments in the polymers and the degree of crosslinking, hydrogels may be tailored to exhibit specific properties.…”

Section: Introductionmentioning

confidence: 99%

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Fast‐swelling Superabsorbent Hydrogels from Poly(2‐hydroxy ethyl acrylate‐co‐sodium acrylate) Grafted on Starch

2008

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Fast-swelling highly porous superabsorbent hydrogels were synthesized through a rapid radical polymerization under normal atmospheric conditions. To synthesize a biopolymer-based superabsorbent hydrogel, 2-hydroxyethyl acrylate (HEA) and sodium acrylate (AANa) were grafted on the starch backbone in an aqueous solution. The graft copolymerization reaction was carried out in the presence of ammonium persulfate (APS) as an initiator and N; N 0 -methylenebisacrylamide (MBA) as a crosslinker in a homogeneous medium. The chemical structure of the hydrogels was confirmed by FT-IR spectroscopy and thermogravimetric analysis (TGA). The morphology of the samples was examined by scanning electron microscopy (SEM). The results indicated that with increasing the amount of sodium acrylate both swelling capacity and swelling under load (AUL) were increased. Preliminary swelling and deswelling behaviors of the hydrogels were also studied. The effects of pH and inorganic salt on the swelling behavior of the hydrogels were investigated as well.

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Section: Effect Of Ph On Swellingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fast‐swelling Superabsorbent Hydrogels from Poly(2‐hydroxy ethyl acrylate‐co‐sodium acrylate) Grafted on Starch

2008

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“…Hydrogels are attracting more attention as drug delivery systems, especially for the controlled release of pharmaceutically active compounds, whether low in molecular weight 1–7 or like peptides and proteins, high in molecular weight. 8–12 Crosslinked polyelectrolytes are insoluble but swellable polymer networks that carry cations or anions at levels ranging from a few mole percent to 100% of the repeating units. In the last few years, much attention has been paid to polyelectrolyte‐type hydrogels that undergo controllable volume changes in response to small variations in the conditions of the solution.…”

Section: Introductionmentioning

confidence: 99%

Investigation of loading and release in PVA‐based hydrogels

Ruiz

Mantecón

Cádiz

2002

J of Applied Polymer Sci

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ABSTRACT:We used Methylene Blue (MB) and Methyl Orange (MO) as model drugs to investigate the controlled release behavior of hydrogels from poly(vinyl alcohol) crosslinked with ethylenediaminetetraacetic dianhydride. The cationic or anionic character of these compounds and the molecular weight between crosslinks of the hydrogel and the concentration of ionizable groups in the hydrogel greatly affected the loading and release of the drugs. MB loading was favored, therefore, by a higher content of negative charges in the hydrogel, although this implied a greater degree of crosslinking and, therefore, a lower mesh size. On the other hand, the overall loading of negative MO, favored by a higher mesh size, was very low because of unfavorable interactions with the electrolyte charges. Release studies showed that one of the parameters that most affected the drug release behavior of these hydrogels was the pH of the solution. MB and MO were not completely released, even at pH 1.

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“…In the last decade, reversible thermochromic hydrogels sensitive to external temperature have been extensively investigated, though, with the exception of poly(N-isopropylacrylamide) (PNIPAAm) hydrogel, they have only rarely been analyzed. PNIPAAm hydrogel, from which many kinds of hydrogels have been derived, is the best known temperature-sensitive polymeric network [3][4][5][6][7][8][9][10]. All of these hydrogels present properties of volume phase transitions when either the temperature or pH changes [4,[11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Facile fabrication, properties and application of novel thermo-responsive hydrogel

Gong

Xin

et al. 2011

Smart Mater. Struct.

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The authors report a novel thermo-responsive hydrogel design based on the thermally induced aggregation of two kinds of nonionic surfactants: triblock copolymer poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (EPE) and 4-octylphenol polyethoxylate (TX-100). In the preparation of the hydrogel, agarose is used to host the aqueous surfactant molecules, allowing them to move freely through its intrinsic network structure. To study it, EPE molecules are labeled with fluorescent Rhodamine B, and the aggregation phenomenon under various temperatures is imaged by fluorescence microscopy. In order to realize flexible control of the opaque/transparent transition temperature (OTTT), the surfactants' aggregation is modified by adding ionic surfactant or salts. The rate of the opaque/transparent transition and applications in the smart window and smart roof based on this kinds of hydrogel are also investigated.

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Swelling and protein absorption/desorption of thermo-sensitive lactitol-based polyether polyol hydrogels

Cited by 20 publications

References 12 publications

Fast‐swelling Superabsorbent Hydrogels from Poly(2‐hydroxy ethyl acrylate‐co‐sodium acrylate) Grafted on Starch

Fast‐swelling Superabsorbent Hydrogels from Poly(2‐hydroxy ethyl acrylate‐co‐sodium acrylate) Grafted on Starch

Investigation of loading and release in PVA‐based hydrogels

Facile fabrication, properties and application of novel thermo-responsive hydrogel

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