Swelling and drug release behavior of calcium alginate/poly (sodium acrylate) hydrogel beads

Bajpai, Sunil; Kirar, Narendra

doi:10.1080/15685551.2015.1092016

Cited by 46 publications

(25 citation statements)

References 17 publications

(14 reference statements)

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“…When compared the swelling %values in PB pH 6.8 and HCl pH 1.2 mediums, much more swelling of the beads at PB pH 6.8 was observed (p<0.05). Similar results were reported by previous studies [12,21,22]. The pH of the medium affects the swelling behaviours of AL beads.…”

Section: Swelling Properties Of Al-beadssupporting

confidence: 91%

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Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam

Uğur¹,

Kandilli²,

Çetin³

et al. 2019

jrp

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The purpose of the present study was to prepare only levetiracetam (LEV) or carbamazepine (CBZ) or their combination (LEV+CBZ)-loaded alginate (AL) beads for oral administration to treat epilepsy and to evaluate their in vitro characteristics. AL beads were prepared using ionotropic gelation method and lyophilized. The bead formulations were evaluated for particles size, surface morphology, encapsulation efficiency and in vitro drug release in PB pH 6.8 and HCl pH 1.2 release mediums. FT-IR was also used to characterize the beads. The mean particle sizes of wet and lyophilized AL beads were in range of 1.609±0.073-1.779±0.078 mm and 1.075±0.182-1.275±0.138 mm, respectively. The encapsulation efficiency (EE%) values of bead formulations were in the range of 18.74-24.65% for LEV and 90.36-94.03% for CBZ. The pH of the medium affects the swelling behaviours of AL beads and the degree of swelling of AL beads increased with increase of pH of release medium, due to exchange of the Ca 2+ ion with Na + . Besides, the pH of the release medium and the high water solubility of LEV affected the drug release rate from beads. AL beads might be useful to use for oral administration of LEV and CBZ to obtain additive/synergistic effect in a combined treatment of epilepsy.Wt: the weight of beads at time (mg); W0: the initial weight of beads (mg).The experiments were carried out in triplicate and data as average was given. Uğur et al. Alginate beads containing LEV+CBZ

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Section: Swelling Properties Of Al-beadssupporting

confidence: 91%

“…It undergoes ionic gelatin in the presence of divalent cations such as CaCl2 in an aqueous medium. AL beads prepared using CaCl2 have been widely used for drug delivery applications, because, AL alginates is a natural, biocompatible, polyanionic, non-toxic copolymer [11,12,13].…”

Section: Introductionmentioning

confidence: 99%

Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam

Uğur¹,

Kandilli²,

Çetin³

et al. 2019

jrp

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show abstract

“…The 2% SA with 5% and 10% drug exhibited a swelling ratio of 120 AE 1.25% and 180 AE 1.29% respectively. In the studies of Bajpai and Kirar [46], where CA/poly (SA) beads were formed using calcium ALG/poly (sodium acrylate), swelling behavior of the beads was observed. The beads exhibited a maximum swelling value of 273% in 1 h and the swelling ratio decreased gradually up to 174% that extended over a total duration of 18 h. Therefore, it is a notable observation that SA hydrogel obtained from natural sources had a higher swelling index in comparison with the commercially purchased SA as reported in their paper.…”

Section: Swelling Index Of Alg Beadsmentioning

confidence: 99%

Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Naidu

Karunya

Kanchana

et al. 2019

Heliyon

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Sodium Alginate (SA) is an excellent carrier in various drug delivery systems. In this study, SA was synthesized from brown seaweed, Turbinaria conoides with a yield of 31.3 ± 0.86%. The analysis of physicochemical properties of extracted alginate (ALG) determined its purity. The structural confirmations of ALG were studied through FTIR, XRD and SEM analysis. Formulation of ALG with collagen (COL) as a wound healing microfilm showed potential anti-inflammatory properties (81.3 ± 1.77%) and sustained drug release. Likewise, the ALG microbead encapsulated with an anticancer drug, Tamoxifen indicated an in vitro sustained release in the range of 62 ± 0.70% - 91 ± 0.56%. The overall swelling behavior of both the hydrogels, microfilm and microbead provides new opportunities for development of natural ALG in this therapeutic era.

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“…The kinetic models used in this study were: (1) a zero-order kinetic model (2) a first-order kinetic model, (3) the Higuchi model, and (4) the Hixcon-Crowell kinetic model. 19–20…”

Section: Methodsmentioning

confidence: 99%

Kinetic investigation of a controlled drug delivery system based on alginate scaffold with embedded voids

Bhasarkar

Bal

2019

Journal of Applied Biomaterials & Functional Materials

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Alginate scaffold has been used widely for controlled release applications because of its ability to provide threedimensional supports for formation of a gel matrix. Alginate gel scaffolds for drug delivery matrices were prepared using a fluidic device. N 2 gas was used in the fluidic device to generate bubbles in the gel layer. The hydrogel matrices with induced voids were compared with hydrogel matrices without voids. This study attempted to identify the release mechanism of vitamin B 12 from the two types of prepared scaffolds, and the data were fitted with different release kinetic models. The results revealed that the alginate scaffold exhibited a controlled release profile and that the corresponding release mechanism followed a first-order kinetic model. Hydrogel scaffolds fabricated with biocompatible polymers using fluidic methods could be promising for controlled drug delivery systems.

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Swelling and drug release behavior of calcium alginate/poly (sodium acrylate) hydrogel beads

Cited by 46 publications

References 17 publications

Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam

Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam

Formulation of alginate based hydrogel from brown seaweed, Turbinaria conoides for biomedical applications

Kinetic investigation of a controlled drug delivery system based on alginate scaffold with embedded voids

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