Swelling and diffusion of PNIPA-based gels for localized chemotherapy and hyperthermia

Oni, Y.; Soboyejo, Winston O.

doi:10.1016/j.msec.2011.09.006

Cited by 16 publications

(11 citation statements)

References 26 publications

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“…In recent years, significant progress has been made in the development of drug delivery devices 1–4 , for localized cancer treatment 5–8 . Such devices have also been shown to have the potential to reduce the side effects associated with bulk chemotherapy and radiotherapy 9,10 .…”

Section: Introductionmentioning

confidence: 99%

“…Such devices, which can be inserted during tumor removal/surgery, can be designed to release cancer drugs to specific tumor sites or remaining cancer cells/tissue that surround the device 6,10,13 . However, there is a need to understand the drug release kinetics associated with implantable devices for the controlled release of cancer drugs 5,6,14 .…”

Section: Introductionmentioning

confidence: 99%

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Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

Danyuo

Ani

Salifu

et al. 2019

Sci Rep

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This paper presents the anomalous release kinetics of a cancer drug (prodigiosin) frompoly-n-isopropyl-acrylamide ( P(NIPA))-based gels. The release exponents, n, which correspond to the drug release mechanisms, were found to be between 0.41 and 1.40. This is within a range that include Fickian case I (n = 0.45) and non-Fickian diffusion (case II) (n > 0.45) for cylindrical drug-loaded structures. The results, however, suggest that the release exponents, n, correspond mostly to anomalous case II and super case II transport mechanics with sigmoidal characteristics. The drug release kinetics of the P(NIPA)-based hydrogels are well described by bi-dose functions. The observed drug release behavour is related to the porosity of the hydrogels, which can be controlled by cross-linking and copolymerization with acrylamide, which also improves the hydrophilicity of the gels. The paper also presents the effects of cancer drug release on cell survival (%), as well as the cell metabolic activities of treated cells and non-treated cells. The implications of the results are discussed for the development of implantable thermosensitive gels for the controlled release of drugs for localized cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

Danyuo

Ani

Salifu

et al. 2019

Sci Rep

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“…Multimodal cancer therapy, consisting of simultaneous hyperthermia and chemotherapy, has been shown to have a synergistic effect that can enhance therapeutic efficiency compared to individual applications of these methods. 6,[18][19][20] Furthermore, magnetic heating has also received a lot of attention, in terms of fundamental and clinical research. [21][22][23] The motivation for the recent interest is the penetration depth of the alternating magnetic field (AMF), 24 which is remotely applied to implantable magnetic materials.…”

Section: Introductionmentioning

confidence: 99%

Novel magnetic heating probe for multimodal cancer treatment

2015

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“…8 white 32 and 34.6 was reported. 17 Withinthecrease, in the concentration of acrylamide from 3% to 12% there is an increase in lower critical solution temperature from 32-43 . It was found that when N1 was soaked in distilled water, insulin and Charantin, the LCSTs of the hydrogel was found to be 32.8 , 34.…”

Section: Characterization Of Poly (N-isopropylacrylamide) Lower Critimentioning

confidence: 99%

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et al. 2019

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The swelling kinetics of charantin from poly (N-isopropyl acrylamide), PNIPAM-based hydrogel, is accomplished through direct weighing, before soaking the gel in fluid/drug solution at controlled temperatures inside a temperature-controlled water bath. The investigation was carried out for application as anti-diabetic drug delivery system. Charantinwas extracted from bitter melon fruit and leaf under a controlled pH of 4.5. The preparation of PNIPAM was done by varying the acrylamide between (3-12)% and it showed an increase in the lower critical solution temperature (LCST) from 32-43 ℃ indicating a direct relationship in distilled water. The effect of changing solution from distilled water, insulin,andcharantin solution, shows that the higher the polarity of the solution, the lower the LCST of the hydrogel. Charantin loaded on hydrogels N1, N2, N3 and N4 were found to be (42.51, 44.57, 43.55 and 44.61) μg/mL, respectively, when soaked in charantin solution of 52.61 μg/mL. Characterization of the hydrogels using Fourier transformed infrared (FTIR) spectroscopy shows that there is physical interaction between the hydrogel matrix and the charantin molecules. The diffusivity of the hydrogels ranged from 1.48 x 10-10 to 5.08 x 10-8 M2/s andtheir release exponentswere ≥ 0.5 indicative of non-Fickian difusional release.

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Swelling and diffusion of PNIPA-based gels for localized chemotherapy and hyperthermia

Cited by 16 publications

References 26 publications

Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

Anomalous Release Kinetics of Prodigiosin from Poly-N-Isopropyl-Acrylamid based Hydrogels for The Treatment of Triple Negative Breast Cancer

Novel magnetic heating probe for multimodal cancer treatment

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