Sweet Syndrome: A Review and Update

Villarreal-Villarreal, César Daniel; Ocampo‐Candiani, Jorge; Villarreal‐Martínez, Alejandra

doi:10.1016/j.adengl.2016.05.021

Cited by 23 publications

(44 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…17 Our results are similar to those described in classic neutrophilic SS, 18 in which approximately 21% of patients have been linked with malignancy; and of these, 85% had hematological disorders, most frequently acute myelogenous leukemia. 19 Therefore, in contrast with what has been previously suggested, we found that HSS is not more frequently associated with hematologic malignancy than classic SS. According to the literature, there seems to be a specific and particularly frequent association between HSS and MDS.…”

Section: Discussioncontrasting

confidence: 99%

Clinicopathologic, Immunohistochemical, and Molecular Features of Histiocytoid Sweet Syndrome

et al. 2017

View full text Add to dashboard Cite

syndrome is a rare histopathologic variant of Sweet syndrome. The nature of the histiocytoid infiltrate has generated considerable controversy in the literature. OBJECTIVE The main goal of this study was to conduct a comprehensive overview of the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome. We also analyze whether this variant of Sweet syndrome is more frequently associated with hematologic malignancies than classic Sweet syndrome. DESIGN This is a retrospective case series study of the clinicopathologic, immunohistochemical, and molecular features of 33 patients with a clinicopathologic diagnosis of histiocytoid Sweet syndrome was conducted in the dermatology departments of 5 university hospitals and a private laboratory of dermatopathology. MAIN OUTCOME AND MEASURES The clinical, histopathological, immunohistochemical, and follow-up features of 33 patients with histiocytoid Sweet syndrome were analyzed. In some cases, cytogenetic studies of the dermal infiltrate were also performed. We compare our findings with those of the literature. RESULTS The dermal infiltrate from the 33 study patients (20 female; median age, 49 years; age range, 5-93 years; and 13 male; median age, 42 years; age range, 4-76 years) was mainly composed of myeloperoxidase-positive immature myelomonocytic cells with histiocytoid morphology. No cytogenetic anomalies were found in the infiltrate except in 1 case in which neoplastic cells of chronic myelogenous leukemia were intermingled with the cells of histiocytoid Sweet syndrome. Authentic histiocytes were also found in most cases, with a mature immunoprofile, but they appeared to be a minor component of the infiltrate. Histiocytoid Sweet syndrome was not more frequently related with hematologic malignancies than classic neutrophilic Sweet syndrome. CONCLUSIONS AND RELEVANCE The dermal infiltrate of cutaneous lesions of histiocytoid Sweet syndrome is composed mostly of immature cells of myeloid lineage. This infiltrate should not be interpreted as leukemia cutis.

show abstract

Section: Discussioncontrasting

confidence: 99%

Clinicopathologic, Immunohistochemical, and Molecular Features of Histiocytoid Sweet Syndrome

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Requena et al recently reported a series of 33 HSS cases, eight (24%) of whom had a hematologic malignancy, of which three were MDS. They concluded that the incidence of hematologic malignancies in HSS cases is comparable to that among classical SS cases, which is estimated at 18% . Other studies have described a possible unique association between HSS and MDS, with one case series reporting MDS in 5/13 (38%) HSS cases and another reporting MDS in 7/22 (31.8%) HSS cases .…”

Section: Discussionmentioning

confidence: 95%

Histiocytoid Sweet syndrome harboring an isocitrate dehydrogenase 1 mutation: A case report and retrospective analysis of 29 cases of histiocytoid Sweet syndrome

2019

View full text Add to dashboard Cite

Histiocytoid Sweet syndrome (HSS) is a rare histopathologic variant of Sweet syndrome that demonstrates dermal and/or subcutaneous infiltrate with a prominent component of myeloid cells resembling histiocytes. It has been known to occur in association with hematologic neoplasms, including myelodysplastic syndrome (MDS) and acute myelogenous leukemia, but whether it confers an increased risk of such neoplasms is controversial. Here, we describe a case of a HSS that led to the diagnosis of MDS with an isocitrate dehydrogenase 1 (IDH‐1) mutation and a corresponding study looking for additional cases of IDH‐1 mutations in biopsies of histiocytoid and conventional Sweet syndrome.

show abstract

“…Sweet syndrome (SS), also referred to as acute febrile neutrophilic dermatosis, was first described by Dr. Douglas Sweet in 1964 1 . The condition affects mostly women aged 30‐60 years presenting fever, leukocytosis, abrupt onset of painful plaques or nodules, and a predominantly dense dermal neutrophilic infiltrate on histopathology 2 . The etiology and pathogenesis of SS are unknown.…”

Section: Introductionmentioning

confidence: 99%

Sweet syndrome associated with malignancies: A retrospective analysis of 25 patients from West China hospital

Hao

Xiao

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare inflammatory disorder characterized by sudden onset of variably tender brightly erythematous‐to‐violaceous papules, plaques, or nodules. To clarify the frequency, clinical course, therapeutic response, and outcome of Sweet syndrome with malignancy. We conducted a retrospective review of patients diagnosed with SS between 2009 and 2019 with a diagnosis of Sweet syndrome in West China hospital. Records were analyzed for variables, clinical features, etiological factors, laboratory results, and treatment outcomes. The 25 cases under study consisted of 14 (56%) females and 11 (44%) males. Mean age was 52.2 years (range: 4‐76 years). Nodules were the commonest lesion presentation (48%), involving mostly the lower limbs (52%). Pain of lesion was identified as the most common symptom (88%), followed by fever (76%) and cough (44%). Among the patients, 52% exhibited the classic form, 48% showed the malignancy‐associated form, and 4% exhibited the drug‐induced form in the setting of malignancy. Acute myeloid leukemia was the most common malignancy, observed in 5 of 12 patients (41.6%). Anemia (P = .002) was associated with malignancy (Chi‐square test).

show abstract

Sweet Syndrome: A Review and Update

Cited by 23 publications

References 81 publications

Clinicopathologic, Immunohistochemical, and Molecular Features of Histiocytoid Sweet Syndrome

Clinicopathologic, Immunohistochemical, and Molecular Features of Histiocytoid Sweet Syndrome

Histiocytoid Sweet syndrome harboring an isocitrate dehydrogenase 1 mutation: A case report and retrospective analysis of 29 cases of histiocytoid Sweet syndrome

Sweet syndrome associated with malignancies: A retrospective analysis of 25 patients from West China hospital

Contact Info

Product

Resources

About