Sweet-Syndrom bei chronisch myeloischer Leukämie

Rauh, G; Gresser, Ursula; Meurer, Michaela; Dörfler, Hans

doi:10.1007/bf01721678

Cited by 10 publications

(5 citation statements)

References 14 publications

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“…In our case the diagnosis of the bullous variant of Sweet's syndrome was confirmed histologically. To our knowledge, few reports of this rare variant of Sweet's syndrome have been published 5–8 …”

Section: Discussionmentioning

confidence: 99%

Bullous variant of Sweet's syndrome

Voelter-Mahlknecht¹,

Bauer²,

Metzler³

et al. 2004

Int J Dermatology

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A 69-year-old woman presented to our clinic as an emergency with erythematous, wellcircumscribed plaques, which were partly vesicular, on her extremities and in her armpits, and additionally hemorrhagic blisters on both her palms and her fingers ( Fig. 1a), which had developed 2 days after the first appearance of the skin lesions. The rapid onset of the lesions (within a few hours) and the pain associated with them were extremely troublesome to the patient. On admission she complained of fever, tiredness and being easily fatigued. Because of a urinary tract infection 1 month prior to admission, trospiumchloride was given. On clinical examination, body temperature was found to be above 38 ° C and infraclavicular lymph nodes were enlarged but not tender. Normal or negative laboratory tests included blood counts, liver and kidney parameters, electrolytes and infection screen. Laboratory examination demonstrated minor leukocytosis and absolute neutrophilia (white blood cell count 10 440 cells/ µ L, neutrophils 8030 cells/ µ L). X-ray screening, abdominal ultrasound and laboratory investigations were all normal.There was no response to antibiotics when erythromycine was given. However, there was a good response to systemic corticosteroids. The patient was treated with a low dosage of prednisolone, beginning at 50 mg/day, which was then tapered off. Skin lesions resolved within 7 days.Histology from a lesion on the patient's left forearm showed a dense interstitial inflammatory infiltration consisting predominantly of neutrophilic granulocytes from the subepidermal layer to the middle of the reticular dermis. Inflammatory cells penetrated into both blood vessels and vessel walls; vasculitis was not prominent. In the lower dermis, perivascular infiltrations of lymphomononuclear cells were found. In addition, intraepidermally multiple partly confluent vesicles, with inclusions of neutrophilic granulocytes, were found, confirming the diagnosis of this rare variant of an acute febrile neutrophilic dermatosis (Fig. 1b).

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Section: Discussionmentioning

confidence: 99%

Bullous variant of Sweet's syndrome

Voelter-Mahlknecht¹,

Bauer²,

Metzler³

et al. 2004

Int J Dermatology

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“…However, hyperresponsiveness of myeloid progenitor cells to G-CSF and enhanced neutrophil functions in the terminal phase, including fMLP-stimulated superoxide production and in vitro production of IL-8 might be strongly related to the pathogenesis of PAP as well as Sweet syndrome and be some clues to elucidate at least a part of BCR/ABL negative CML. 24 1998 CML (1) SS Pertusi et al 25 1996 CML (1) SS Kannan et al 26 1995 CML (1) SS Brodkin and Schwartz 27 1995 CML (1) SS Dieguez et al 28 1993 CML (1) SS Torri et al 29 1993 CML (1) SS Feliu et al 30 1992 CML (2) SS Sanchez-Yus and Palou 31 1992 CML (1) SS Gonzalez-Castro et al 32 1991 CML (1) SS Mijovic et al 33 1991 CML (1) SS Elovaara et al 34 1990 CML (1) SS Bello Lopez et al 35 1990 CML (1) SS Cohen and Kurzrock 36 1989 CML (1) SS Hatch et al 37 1989 CML (1) SS Rauh et al 38 1989 CML (1) SS Visani et al 39 1988 CML (1) SS Marcos Sanchez et al 40 1985 CML (1) SS Odeh 41 1981 CML (1) SS Chmel and Armstrong 42 1978 CML (1) SS Rodriguez-Luaces et al 43 1997 CML (1) PAP Cordonnier et al 3 1994 CML (4) PAP Ito et al 44 1994 CML (1) PAP Miyake et al 45 1992 CML (1) PAP Watanabe et al 46 1990 CML (1) PAP Magy et al 47 1985 CML (1) PAP Aymard et al 48 1984 CML (1) PAP Green et al 49 1980 CML (1) PAP Miyashita et al 50 1977 CML (1) PAP Yamamoto et al 51 1975 CML (1) PAP Nakamura et al 52 1988 Graves (1) SS CML: chronic myeloid leukemia; PAP: pulmonary alveolar proteinosis; SS: Sweet syndrome.…”

Section: Discussionmentioning

confidence: 99%

Hyperfunction of neutrophils in a patient with BCR/ABL negative chronic myeloid leukemia

Watari

Tojo

Nagamura‐Inoue

et al. 2000

Cancer

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“…Mögliche Trigger sind Infektionserkrankungen, Arzneimittel und Neoplasien [13]. Die Häufigkeitsangaben zur Tumorassoziation schwanken in der Literatur und gehen bis zu 50 % [14].…”

Section: Sweetsyndromunclassified

Hautveränderungen bei malignen hämatologischen Erkrankungen

Schmid‐Wendtner¹,

Hornung

Meurer³

et al. 2015

Hautarzt

Self Cite

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Numerous cutaneous manifestations have been reported in patients with hematologic malignancies. This review provides an overview on this subject by dividing skin lesions into three main groups: (1) skin disorders due to vascular changes (dilatation, occlusion and inflammation), (2) unspecific (e.g. paleness, opportunistic infections) and specific skin lesions (e.g. leukemia cutis), and (3) the large group of paraneoplastic skin disorders. Emphasis is placed on clinical findings and therapeutic options of those paraneoplastic syndromes that are most frequently found in hematologic malignancies.

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Sweet-Syndrom bei chronisch myeloischer Leukämie

Cited by 10 publications

References 14 publications

Bullous variant of Sweet's syndrome

Bullous variant of Sweet's syndrome

Hyperfunction of neutrophils in a patient with BCR/ABL negative chronic myeloid leukemia

Hautveränderungen bei malignen hämatologischen Erkrankungen

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