Sweet Success: Ionic Liquids Derived from Non‐Nutritive Sweeteners.

Abstract

Solvents SolventsV 2000 Sweet Success: Ionic Liquids Derived from Non-Nutritive Sweeteners. -The anions of the sweeteners saccharin and acesulfame form ionic liquids when paired with a variety of organic cations. -(CARTER, E. B.; CULVER, S. L.; FOX, P. A.; GOODE, R. D.; NTAI, I.; TICKELL, M. D.; TRAYLOR, R. K.; HOFFMAN*, N. W.; DAVIS, J. H. J.; Chem.

Choline Saccharinate and Choline Acesulfamate: Ionic Liquids with Low Toxicities

“…Ionic liquids with counterions such as saccharinate or acesulfamate have been described. 107,108 Advantages are their well-established toxicological properties, easy availability, and low price (these are salts of artificial sweeteners). Thus by combining these anions with a choline cation, which is derived from choline chloride (an essential vitamin-like nutrient used as a chicken feed additive), these ionic liquids are expected to have a very low toxicity.…”

Ionic Liquids Then and Now: From Solvents to Materials to Active Pharmaceutical Ingredients

“…[59][60][61][62] These were paired with traditional IL-forming counter ions to control physical properties, especially melting point, but with a focus on preparing ILs, not on preparing biologically active salts. In fact only recently, have specific ILs with biologically active ions been prepared and shown to retain their biological activity; specifically, IL salts of anti-bacterial quaternary ammonium cations were shown to be active against various types of bacteria and in some cases, an increased anti-bacterial effect was observed.…”

Arene ruthenium bis-saccharinato complexes: Synthesis, molecular structure and catalytic oxidation properties in aqueous solution

“…Its water-soluble sodium salt therefore is widely used as artificial sweetener for diabetics as well as an additive in dietetic products. Recently, it has also been used for ionic liquids [10]. The saccharinate anion has been shown to coordinate to Cr, Zn, V, Pb, Hg, Mn, Co, and the complexes [M(sacc) 2 (OH 2 ) 4 ] (M ¼ Cr, Zn) [11]; [V(sacc) 2 4 ] $ 2 py (py ¼ pyridine) [12]; [Pb(sacc) 2 ] $ H 2 O [13]; [HgCl(py)(sacc)] 2 [14]; [Mn(phen) 2 (sacc)(OH 2 )](sacc), [Co(bipy)2-(sacc)(OH 2 )](sacc) (phen ¼ phenanthroline, bipy ¼ bipyridine) [15]; [Zn(sacc) 2 [16] have been reported.…”