Sweet's Syndrome with Small Cell Carcinoma of the Lung

Yamamoto, Toshiyuki; Furuse, Yoshiro; Nishioka, Kiyoshi

doi:10.1111/j.1346-8138.1994.tb01428.x

Cited by 8 publications

(4 citation statements)

References 11 publications

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“…1 The etiology of this syndrome remains unknown; however, it has been suggested that it may be a manifestation of an abnormal reaction of neutrophilic granulocytes to unknown antigens 4 or might be a hypersensitivity reaction to an infectious or chemical agent, or to tumorassociated antigens. 5 Because of the presence of systemic problems such as arthritis or the response to steroids, several investigators have suggested that an immunologic mechanism is involved. 1 Untreated skin lesions often resolve spontaneously within 3 months.…”

Section: Discussionmentioning

confidence: 99%

Lung cancer associated with Sweet’s syndrome: Report of a case

et al. 2008

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Lung cancer associated with Sweet's syndrome is extremely rare. There are only seven reports of such cases. As far as could be determined from a comprehensive search, there is no reported operative case of lung cancer with this syndrome in the world literature. A 75-year-old Japanese man was diagnosed as having Sweet's syndrome. A chest computed tomography (CT) scan to screen for malignant lesions associated with this syndrome revealed an abnormal shadow in the lung. Although [(18)F]2-fluoro-2-deoxy-D: -glucose positron emission tomography showed no abnormal uptake, lung cancer was most strongly suspected by chest CT. His erythema improved rapidly with steroid therapy and he underwent a segmentectomy (S(6)) of the right lower lobe. A pathological examination revealed lung adenocarcinoma (pT1N0M0: Stage Ia). The patient was discharged from the hospital without any worsening of Sweet's syndrome. We herein report a first operative case of an early stage lung adenocarcinoma with this syndrome.

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Section: Discussionmentioning

confidence: 99%

Lung cancer associated with Sweet’s syndrome: Report of a case

et al. 2008

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“…Pubmed üzerinden günümüze kadar yapılan literatür taramasında; akciğer maligniteli Sweet Sendromu nadir olup, toplam 8 tane Sweet Sendrom tanılı vakayı görmekteyiz (23,(25)(26)(27)(28)(29)(30)(31).…”

Section: Discussionunclassified

Nadir Görülen Bir Paraneoplastik Sendrom; Sweet Sendromu

Güney

Şahin

2021

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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Paraneoplastic Syndrome; It is called a clinical picture that does not occur due to an effect of the primary tumor or its metastases, but consists of signs and symptoms that develop depending on the presence of the tumor. Paraneoplasias can be seen during the course of a tumor with a known presence, as well as being the first and only sign of a hidden tumor that has not emerged clinically, it can help to identify primary cancer at an early stage. Sweet's Syndrome, also called acute febrile neutrophilic dermatosis; It is a rare, recurrent inflammatory skin disease characterized by sudden onset, painful, inflammatory papules or nodules with erythematous plaques, fever, joint pain, peripheral leukocytosis and intense neutrophil infiltration in the dermis layer of the skin. Illness; It can be observed as inflammatory bowel disease, infections, secondary to drugs secondary to malignancy (paraneoplastic). In this article, we aimed to present a case of a 69-year-old male patient who was hospitalized with acute rash and fever with a pre-diagnosis of Sweet Syndrome and was diagnosed with metastatic lung carcinoid tumor in the following etiological investigation.

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“…Sweet syndrome is frequently described in association with hematogenous malignancy such as chronic myeloid leukemia and lymphoma [50, 54, 90–96]; because of this frequent finding many scientists deem it a paraneoplastic phenomenon [92]. However, while this association is well established for liquid tumors, it is rare with solid tumors including lung cancer.…”

Section: Neutrophilic Dermatosesmentioning

confidence: 99%

“…Only seven cases were published describing an association between Sweet syndrome and lung cancer [95]. The first case with lung adenocarcinoma was described by Nielsen et al in 1993 [92] and one year later Yamamoto et al identified the first case with small cell lung cancer [93]. It was postulated that paraneoplastic production of IL-8, G-CSF, and GM-CSF by malignant cells was responsible for the extensive recruitment of PMN leukocytes to the skin, accounting for the development of Sweet's syndrome [97].…”

Section: Neutrophilic Dermatosesmentioning

confidence: 99%

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

Salem

Kimak

Conic

et al. 2019

BioMed Research International

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Neutrophilic dermatoses (ND) are a polymorphous group of noncontagious dermatological disorders that share the common histological feature of a sterile cutaneous infiltration of mature neutrophils. Clinical manifestations can vary from nodules, pustules, and bulla to erosions and ulcerations. The etiopathogenesis of neutrophilic dermatoses has continuously evolved. Accumulating genetic, clinical, and histological evidence point to NDs being classified in the spectrum of autoinflammatory conditions. However, unlike the monogenic autoinflammatory syndromes where a clear multiple change in the inflammasome structure/function is demonstrated, NDs display several proinflammatory abnormalities, mainly driven by IL-1, IL-17, and tumor necrosis factor-alpha (TNF-a). Additionally, because of the frequent association with extracutaneous manifestations where neutrophils seem to play a crucial role, it was plausible also to consider NDs as a cutaneous presentation of a systemic neutrophilic condition. Neutrophilic dermatoses are more frequently recognized in association with respiratory disorders than by chance alone. The combination of the two, particularly in the context of their overlapping immune responses mediated primarily by neutrophils, raises the likelihood of a common neutrophilic systemic disease or an aberrant innate immunity disorder. Associated respiratory conditions can serve as a trigger or may develop or be exacerbated secondary to the uncontrolled skin disorder. Physicians should be aware of the possible pulmonary comorbidities and apply this knowledge in the three steps of patients’ management, work-up, diagnosis, and treatment. In this review, we attempt to unravel the pathophysiological mechanisms of this association and also present some evidence for the role of targeted therapy in the treatment of both conditions.

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Sweet's Syndrome with Small Cell Carcinoma of the Lung

Cited by 8 publications

References 11 publications

Lung cancer associated with Sweet’s syndrome: Report of a case

Lung cancer associated with Sweet’s syndrome: Report of a case

Nadir Görülen Bir Paraneoplastik Sendrom; Sweet Sendromu

Neutrophilic Dermatoses and Their Implication in Pathophysiology of Asthma and Other Respiratory Comorbidities: A Narrative Review

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