Sweet′s syndrome in human immune deficiency virus-infected patient

Rajendran, Adarsh; Zacharia, George Sarin; Zacharia, Sue Ann; George, K. C.

doi:10.4103/0253-7184.142413

Cited by 6 publications

(6 citation statements)

References 5 publications

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“…For instance, ND is not commonly observed in NTM infections (3,24,25). Moreover, it is rarely reported in HIV infected individuals (26)(27)(28). Until recently, ND has been reported to be found in NTM patients affected by this syndrome (1,3,14,15).…”

Section: Discussionmentioning

confidence: 99%

Skin Manifestations in Patients with Adult-onset Immunodeficiency due to Anti-interferon-gamma Autoantibody: A Relationship with Systemic Infections

Jutivorakool¹,

Sittiwattanawong²,

Kantikosum³

et al. 2018

Acta Derm Venerol

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Adult-onset immunodeficiency due to anti-interferon-γ autoantibody is an emerging acquired immunodeficiency with frequent skin manifestations. A retrospective chart review was conducted and identified 41 patients with the syndrome. Skin involvement was detected in 33 (80%) patients, 15 (45%) with infective skin diseases and 27 (82%) with reactive skin disorders. Reactive lesions were mostly neutrophilic dermatoses, e.g. Sweet syndrome. Of note, the presence of neutrophilic dermatoses was highly associated with infections of other sites. An adjusted odds ratio for the existence of infections in patients with neutrophilic dermatoses was 14.79 (95% CI: 5.13, 42.70; p < 0.001). Moreover, neutrophilic dermatoses were significantly correlated with opportunistic infections observed in those with defects in cell-mediated immunity including non-tuberculous mycobacterium and disseminated fungal infection. The odds ratio for opportunistic infections in the presence of neutrophilic dermatoses was 12.35 (95% CI: 5.00, 30.55; p <0.001). Thus, the presence of neutrophilic dermatoses in patients with the syndrome can signal opportunistic infections that warrant physician attention.

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Section: Discussionmentioning

confidence: 99%

Skin Manifestations in Patients with Adult-onset Immunodeficiency due to Anti-interferon-gamma Autoantibody: A Relationship with Systemic Infections

Jutivorakool¹,

Sittiwattanawong²,

Kantikosum³

et al. 2018

Acta Derm Venerol

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“…En cuanto al tratamiento del SIRI en personas que viven con VIH, se han utilizado corticosteroides sistémicos para disminuir la tormenta de citocinas inflamatorias, sobre todo en casos extensos en los que la estancia intrahospitalaria disminuye, al igual que los síntomas sistémicos 13 . En pacientes en los que se presenta SS se ha reportado el uso de prednisona o prednisolona 1 mg/kg/día en dosis reducción 15,16 , inmunoglobulina intravenosa, dapsona 50-100 mg 14 , indometacina 17 y talidomida 100 mg/día 3 asociados con el TAR con buena respuesta. La duración del tratamiento es variable, la cual puede ser de días a meses dependiendo de la causa del SIRI 11 .…”

Section: Discussionunclassified

Síndrome de <i>Sweet</i> secundario a síndrome inflamatorio de reconstitución inmune: reporte de 2 casos

Fernández-Sánchez,

Lomelí-Canedo,

Pizano-Márquez

2023

MCUT

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El síndrome de Sweet (SS) es una entidad poco frecuente, perteneciente al grupo de las dermatosis neutrofílicas, caracterizada por la aparición abrupta de pápulas, placas o nódulos asociados a fiebre y otros síntomas sistémicos. Hasta ahora no se ha establecido una relación directa con el VIH, sin embargo existen escasos casos reportados asociados al síndrome inflamatorio de reconstitución inmune (SIRI). Presentamos dos casos en mujeres mexicanas que viven con VIH, con criterios diagnósticos de SS asociado a SIRI, enfatizando que este síndrome debe considerarse como un diagnóstico diferencial en el contexto de reciente inicio de la terapia antirretroviral.

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“…There was significant heterogeneity in treatment approaches for Sweet syndrome in those living with HIV, though a majority of treatments involved systemic anti-inflammatory and/or immunosuppressive therapies [ 4 - 7 , 9 - 11 , 13 - 16 , 20 ]. Duration of treatment was also variable, but successful treatments ranged from as little as ten days with a course of saturated potassium iodide solution [ 7 ], to two months of prednisone [ 4 ], often with a complete response to treatment [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Sweet Syndrome in an Elderly Man With Well-Controlled Human Immunodeficiency Virus

Mudroch

Rohan

Conger

et al. 2020

Cureus

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Acute febrile neutrophilic dermatosis, or Sweet syndrome, is a rare disorder associated with medications, underlying malignancy, or systemic inflammatory conditions. We present the case of a 71-year-old male living with well-controlled human immunodeficiency virus (HIV) on antiretroviral therapy, who presented with multiple painful, pseudo-vesicular, almost-necrotic appearing papules on his bilateral palms in the setting of constitutional symptoms and altered mental status. Biopsy of his palmar lesions revealed a dense, diffuse, dermal neutrophilic infiltrate consistent with Sweet syndrome. Infectious, rheumatologic, and oncologic work-up was negative. He was treated initially with intravenous immunoglobulin, prednisone, and dapsone; and he was continued on suppressive dapsone. He responded well clinically, but he relapsed multiple times in the setting of medication non-adherence before his ultimate diagnosis with sarcoidosis. A review of the literature of persons living with HIV and diagnosed with Sweet syndrome reveals no clear clinical association between the two despite plausible pathologic mechanisms. Patients living with HIV who are diagnosed with Sweet syndrome should be evaluated thoroughly for potential etiologies; the search for the underlying etiology of Sweet syndrome should go beyond their diagnosis of HIV.

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Sweet′s syndrome in human immune deficiency virus-infected patient

Cited by 6 publications

References 5 publications

Skin Manifestations in Patients with Adult-onset Immunodeficiency due to Anti-interferon-gamma Autoantibody: A Relationship with Systemic Infections

Skin Manifestations in Patients with Adult-onset Immunodeficiency due to Anti-interferon-gamma Autoantibody: A Relationship with Systemic Infections

Síndrome de <i>Sweet</i> secundario a síndrome inflamatorio de reconstitución inmune: reporte de 2 casos

Sweet Syndrome in an Elderly Man With Well-Controlled Human Immunodeficiency Virus

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