Sweet's syndrome in Behçet's disease

Hassikou, H.; Tabache, Fatima; Baaj, M. El; Safi, S.; Hadri, L.

doi:10.1016/j.jbspin.2006.11.022

Cited by 15 publications

(11 citation statements)

References 8 publications

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“…In addition to the two major criteria (abrupt onset of tender or painful erythematous or violaceous plaques or nodules and neutrophilic infiltration of the dermis without leukocytoclastic vasculitis), he had three minor criteria (elevation of the CRP level, leukocytosis and preceding slight fever) [2]. Like our case report, cases of SS with recurrent oral ulcerations were reported [1,[4][5][6][7]. They had tender erythematous nodular or vesicle-like papular skin eruptions on both forearms [5], over the face, neck, palms and legs [4], multicentric erythema and pustules progressing to ulcers on the legs, face, trunk and extremities [7], and erythematous plaques on the legs [6].…”

Section: Discussionsupporting

confidence: 62%

“…Edema and aggregates of neutrophils were common in the epidermis and upper dermis, but there was no vasculitis. Treatment with systemic prednisolone only [6] or associated with oral cyclosporine [5], or colchicine [4], led to remission.…”

Section: Discussionmentioning

confidence: 98%

“…They had tender erythematous nodular or vesicle-like papular skin eruptions on both forearms [5], over the face, neck, palms and legs [4], multicentric erythema and pustules progressing to ulcers on the legs, face, trunk and extremities [7], and erythematous plaques on the legs [6]. Painful oral lesions were present on the mucous membrane and the lower lip [7], and on the palate and the lower labial mucosa [6], associated with genital ulcers [4]. All had an inflammatory syndrome with an elevated C-reactive protein level.…”

Section: Discussionmentioning

confidence: 99%

“…Common to all, there is a disorder of stimuli and proliferation of neutrophils, expressed by cellular skin infiltration [3]. A few cases of oral involvement have been reported in patients with ND and were mainly associated with SS [4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Sweet’s syndrome revealed by oral pustulosis

Fricain

Sibaud

Lepreux

et al. 2015

Med Buccale Chir Buccale

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-Introduction:Neutrophilic dermatoses are conditions characterized by a dermal neutrophilic infiltration associated with variable leukocytoclasia. Oral involvement occurs but is rare and is of less importance than the cutaneous involvement. Observation: The case of a 71-year-old man with neutrophilic dermatoses in whom the major manifestations of the disease were recurrent oral ulcers associated with tongue pustulosis is reported. Oral and skin biopsies revealed a dense neutrophilic infiltrate in the lamina propria. Clinical symptoms were quickly resolved with colchicine treatment. The clinical course allowed us to diagnose Sweet's syndrome associated with oral pustulosis. Discussion: The main differential diagnosis of Sweet's syndrome is from Behçet's disease. Overlap exists between the manifestations of the two diseases, so they must be differentiated. The recurrence of oral ulcers with little inflammatory halo and the quick resolution of ulcers associated with pustules, as well as the histological patterns, were not compatible with Behçet's disease. Résumé -Introduction :Les dermatoses neutrophiles sont caractérisées par une infiltration neutrophilique cutanée associée à une leucocytoclasie. Les manifestations orales sont rares et moins bruyantes qu'au niveau de la peau. Observation : Le cas d'un homme de 71 ans avec une dermatose neutrophile dont les principales manifestations de la maladie étaient des ulcères buccaux récurrents associés à une pustulose linguale est rapporté. Les biopsies buccales et cutanées ont révélé un infiltrat neutrophilique dense dans la lamina propria. Les symptômes cliniques ont été rapidement résolus avec de la colchicine. L'évolution clinique a permis de diagnostiquer un syndrome de Sweet associé à une pustulose orale. Discussion : Le principal diagnostic différentiel du syndrome de Sweet est la maladie de Behçet. Des chevauchements existent entre les manifestations cliniques des 2 entités. Mais celles-ci n'ont pas le même pronostic et doivent être différenciées. La récurrence des ulcères buccaux avec un discret halo inflammatoire, la résolution rapide des ulcères associés aux pustules ainsi que les aspects histologiques du cas décrit, n'étaient pas compatibles avec la maladie de Behçet.

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sweet’s syndrome revealed by oral pustulosis

Fricain

Sibaud

Lepreux

et al. 2015

Med Buccale Chir Buccale

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“…Behçet's disease may also present with skin lesions, described as papular or pustular pseudofolliculitis or as erythema nodosum of the lower extremities, in the setting of genital and oral ulcerations, arthritis, vascular and cardiac abnormalities such as thrombotic events and cardiomyopathy. Skin findings are predominant in Sweet's syndrome, while oral and genital ulcers are rare [10]. Both conditions are said to have good response to glucocorticoid therapy.…”

Section: Discussionmentioning

confidence: 99%

Sight-Threatening Ocular Manifestations of Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome)

Baartman

Kosari²,

Warren³

et al. 2014

Dermatology

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Sweet's syndrome is a primarily dermatologic disorder with many features of systemic inflammation. It is generally characterized by a neutrophilic dermatosis in the setting of fever and an elevated white blood cell count. Inflammation has been described to occur in many organ systems including the lung, bone, liver, spleen, brain and eye. Ocular inflammation is a well-known comorbidity that may occur in the setting of Sweet's syndrome, including conjunctivitis, episcleritis, scleritis, iritis and choroiditis, among other forms. In the current article, we have compiled a series of cases that describe three separate patients who demonstrated a rare form of ocular involvement in Sweet's syndrome, retinal vasculitis. The evidence from these three cases and other reports in recent ophthalmologic literature suggest overlapping of ocular manifestations of Sweet's syndrome and the closely related Behçet's disease. It is important to be aware of the sometimes challenging differential between these two disorders and their sight-threatening complications.

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