Sweet's Syndrome During Treatment with All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

Arun, Banu; Berberian, Brenda J.; Azumi, Norio; Frankel, Stanley R.; Luksenburg, Harvey; Freter, Carl E.

doi:10.3109/10428199809057622

Cited by 41 publications

(25 citation statements)

References 8 publications

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“…37 Some cases of ND have been induced by treatments with colony-stimulating factors 38 or all-trans retinoic acid. 39 In rare instances, ND have appeared as unexpected side effects of diverse drug therapies 40 (tetracyclines).…”

Section: Associated Systemic Diseasesmentioning

confidence: 99%

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

Wallach

Vignon‐Pennamen

2006

Journal of the American Academy of Dermatology

199

122

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Section: Associated Systemic Diseasesmentioning

confidence: 99%

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

Wallach

Vignon‐Pennamen

2006

Journal of the American Academy of Dermatology

199

122

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“…Other side effects, including bone marrow necrosis [11], hypercalcemia [122], erythema nodosum [123], marked basophilia [124,125], severe myositis [126], Sweet syndrome [127,128], Fournier's gangrene (necrotizing fasciitis of the penis and scrotum) [129,130], thrombocytosis [131], and necrotizing vasculitis [132] have rarely been reported with ATRA treatment.…”

Section: Other Side Effects Of Atramentioning

confidence: 99%

Treatment of Acute Promyelocytic Leukemia by Retinoids

Fenaux¹,

Wang²,

Degos³

2007

Acute Promyelocytic Leukemia

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“…Sweet's syndrome, an acute febrile neutrophilic dermatosis, has been reported in patients with acute promyelocytic leukemia after ATRA therapy and is characterized by fever, neutrophilia, painful ulcer-like plaques, and rapid response to steroid therapy. [19][20][21][22][23][24][25][26][27][28][29] This is often linked to or followed by the retinoic acid syndrome, a distinct clinical syndrome reported in up to one-quarter of patients treated with ATRA characterized by fever, dyspnea, hypotension, pleural or pericardial effusions and weight gain. 30 ATRA-associated genital ulcerations, [11][12][13][14][15][16][17][18] and ATRA-associated vasculitis 31 and myositis 32 have also been described in patients with acute promyelocytic leukemia.…”

Section: Discussionmentioning

confidence: 99%

Fluorescence in situ hybridization investigation of cutaneous lesions in acute promyelocytic leukemia

et al. 2005

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Cutaneous manifestations of acute promyelocytic leukemia are rare but well documented. Skin biopsies of leukemia can be difficult to confirm using morphology alone, and paraffin section immunophenotyping is not specific in separating acute promyelocytic leukemia from other acute myeloid leukemias involving the skin or inflammatory conditions, such as Sweet's syndrome and all-trans retinoic acid-associated genital ulcers, which may mimic leukemia cutis. Fluorescence in situ hybridization has been shown to be a fast and effective method of detecting the PML/RARA fusion gene characteristic of acute promyelocytic leukemia in fresh blood and bone marrow samples. Fluorescence in situ hybridization has also been demonstrated to be effective in detecting other chromosomal rearrangements in paraffin-embedded tissue. This retrospective study of cutaneous lesions from four patients with acute promyelocytic leukemia evaluates the utility of performing fluorescence in situ hybridization to confirm the presence of cutaneous manifestations of acute promyelocytic leukemia in formalinfixed, paraffin-embedded skin biopsies. All patients had previous bone marrow findings of acute promyelocytic leukemia with characteristic morphology, immunophenotype, and cytogenetic studies, which detailed the presence of the t(15;17)(q22;q12) rearrangement. Two skin biopsies showed an infiltrate of blastic cells involving the dermis in a diffuse pattern and one biopsy had a perivascular/periadnexal pattern. The fourth case, involving the scrotum, showed a predominant neutrophilic infiltrate diffusely involving the dermis and epidermis with a subset of blastic cells. Nuclei were extracted from core biopsies of the formalin-fixed paraffinembedded tissue and fluorescence in situ hybridization was performed using a dual color, dual fusion PML/ RARA probe. All cases showed evidence of the t(15;17) rearrangement, with 90, 79, 51 and 16% positive signal patterns, each well above background limits. Fluorescence in situ hybridization appears to be a robust technique to detect cutaneous manifestations of acute promyelocytic leukemia in formalin-fixed paraffinembedded skin biopsies. Modern Pathology (2005) 18, 1569-1576.

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Sweet's Syndrome During Treatment with All-Trans Retinoic Acid in a Patient with Acute Promyelocytic Leukemia

Cited by 41 publications

References 8 publications

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

From acute febrile neutrophilic dermatosis to neutrophilic disease: Forty years of clinical research

Treatment of Acute Promyelocytic Leukemia by Retinoids

Fluorescence in situ hybridization investigation of cutaneous lesions in acute promyelocytic leukemia

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