Sweet's syndrome as the presenting symptom of hairy cell leukemia with concomitant infection by Mycobacterium kansasii

Kramers, C.; Raemaekers, John; Baar, H.M.J. van; Pauw, B.E. de; Horrevorts, A. M.

doi:10.1007/bf01715129

Cited by 19 publications

(14 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Sweet syndrome associated with hairy cell leukemia is rare. On, the literature review, there have only been nine cases reported [6–10]. Of interest in this particular patient is the manifestation of Sweets syndrome in the setting of neutropenia not neutrophilia.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Hairy Cell Leukemia Presenting Concomitantly with Sweet Syndrome

Alkayem

Cheng

2014

Case Reports in Medicine

View full text Add to dashboard Cite

Hairy cell leukemia and Sweet syndrome are both uncommon hematological diagnoses. We present a patient who was admitted with fevers, pancytopenia, pneumonia, and rash. Diagnostic bone marrow biopsy demonstrates Hairy cell Leukemia and skin biopsy demonstrates neutrophils infiltration consistent with Sweet syndrome. The patient was treated with purine analogs with resolution of the cytopenias, infection, and rash.

show abstract

Section: Discussionmentioning

confidence: 99%

A Case Report of Hairy Cell Leukemia Presenting Concomitantly with Sweet Syndrome

Alkayem

Cheng

2014

Case Reports in Medicine

View full text Add to dashboard Cite

show abstract

“…Various infectious agents including bacteria, viruses, fungi and rickettsias are reported to be associated with the syndrome; however, non-tuberculous mycobacterial infection (NTMI) is rarely seen in a patient with Sweet's syndrome. [3][4][5][6][7] We here report five cases of Sweet's syndrome in association with NTMI.…”

mentioning

confidence: 99%

Sweet's syndrome associated with non-tuberculous mycobacterial infection: a report of five cases

et al. 1998

View full text Add to dashboard Cite

We report the rare association of Sweet's syndrome with non-tuberculous mycobacteria in five patients (three women, two men, aged 25-41 years). Clinical and histological evidence supported the diagnosis of Sweet's syndrome in all patients. The skin lesions responded well to systemic corticosteroid but recurred in two cases. All of our patients had chronic disseminated non-tuberculous mycobacterial infection. They initially presented with lymphadenopathy and developed involvement in other organs later. All of them were treated as having tuberculous lymphadenitis based on pathological findings before definite diagnosis was made by culture. The organisms isolated were Mycobacterium chelonae in three cases, M. scrofulaceum in one case and M. avium intracellulare complex in one case. All the patients gradually improved with treatment but one had multiple recurrences. The search for an infectious agent, especially non-tuberculous mycobacteria, should be performed in cases of Sweet's syndrome that appear in association with chronic granulomatous lymphadenitis which is recalcitrant to antituberculous drugs.

show abstract

“…[7][8][9] The mechanism that renders patients with hairy-cell leukemia susceptible to infection with mycobacterial and other intracellular pathogens may involve deficiencies in the production of interferon gamma. Descriptions of M. tuberculosis infections in patients with hairycell leukemia are rare.…”

Section: Commenta R Ymentioning

confidence: 99%

A Man with Fever, Cough, and Rash

Geller¹,

Stone²,

Merola³

et al. 2015

N Engl J Med

View full text Add to dashboard Cite

A 67-year-old man with hairy-cell leukemia presented to the clinic with a 3-day history of fevers (with temperatures as high as 38.7°C), night sweats, arthralgias, and an erythematous, vesicular-appearing rash on his back. He had had no sick contacts, had not traveled outside the United States for more than 20 years, and had no pets at home. He reported no headaches, shortness of breath, cough, rhinorrhea, bleeding episodes, nausea, vomiting, or diarrhea.Infectious complications in patients with hairy-cell leukemia are common and would be my initial source of concern. Given the nature of the rash, I would also suspect disseminated viral processes, such as a herpes or varicella infection. Other viruses, such as coxsackievirus and enterovirus, may also cause a similar exanthem. Drug eruptions, early Stevens-Johnson syndrome, contact dermatitis, and autoimmune blistering diseases may also be manifested in this manner.The diagnosis of hairy-cell leukemia was made 17 years before the patient's current presentation. At that time, he had a response to chemotherapy with cladribine. The patient had a relapse 10 years before presentation, at which time the administration of cladribine was again effective, although in this instance treatment was complicated by a cardiomyopathy that subsequently resolved. Five months before his current presentation, he received eight doses of rituximab for pancytopenia due to recurrent disease, but his blood counts did not improve.The patient's medical history was otherwise notable for prostate cancer, for which he had undergone a curative radical prostatectomy 12 years ago, and hyperlipidemia. There had been no recent change in his medications, which included 10 mg of simvastatin nightly and 81 mg of aspirin daily. He also took a multivitamin. The patient was born in the United States, was retired from work in the television industry, and was married, with two children. He did not smoke, drink alcohol, or use illicit drugs.On physical examination, he appeared well and was in no acute distress. His temperature was 38.3°C, heart rate 82 beats per minute, blood pressure 136/80 mm Hg, respiratory rate 16 breaths per minute, and oxygen saturation 99% while breathing ambient air. The mucous membranes were moist. The chest examination was normal; the cardiac examination revealed a normal rate and rhythm, with no murmurs.In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors' commentary follows. The New England Journal of Medicine Downloaded from nejm.org at UNIVERSITY OF OTAGO on July 3, 2015. For personal use only. No other uses without permission.

show abstract

Sweet's syndrome as the presenting symptom of hairy cell leukemia with concomitant infection by Mycobacterium kansasii

Cited by 19 publications

References 15 publications

A Case Report of Hairy Cell Leukemia Presenting Concomitantly with Sweet Syndrome

A Case Report of Hairy Cell Leukemia Presenting Concomitantly with Sweet Syndrome

Sweet's syndrome associated with non-tuberculous mycobacterial infection: a report of five cases

A Man with Fever, Cough, and Rash

Contact Info

Product

Resources

About