Sweet memories: epigenetic control in flowering

Müller, Ralf; Goodrich, Justin

doi:10.3410/b3-13

Cited by 14 publications

(11 citation statements)

References 40 publications

(29 reference statements)

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“…Obviously, the reciprocal and hierarchical regulations of the TFs contribute to their distinct spatiotemporal expression pattern. Nevertheless, epigenetic regulation can stabilize gene networks, restrict gene expression to specific tissue and/or provide a time buffer, which allows delayed transcriptional response to an upstream TFs (Müller and Goodrich, 2011;Xiao et al, 2016).…”

Section: Key Transcriptional Regulators Of Dnrrmentioning

confidence: 99%

Reprogramming of Cell Fate During Root Regeneration by Transcriptional and Epigenetic Networks

Jing

Ardiansyah

et al. 2020

Front. Plant Sci.

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Many plant species are able to regenerate adventitious roots either directly from aerial organs such as leaves or stems, in particularly after detachment (cutting), or indirectly, from over-proliferating tissue termed callus. In agriculture, this capacity of de novo root formation from cuttings can be used to clonally propagate several important crop plants including cassava, potato, sugar cane, banana and various fruit or timber trees. Direct and indirect de novo root regeneration (DNRR) originates from pluripotent cells of the pericycle tissue, from other root-competent cells or from non-root-competent cells that first dedifferentiate. Independently of their origin, the cells convert into root founder cells, which go through proliferation and differentiation subsequently forming functional root meristems, root primordia and the complete root. Recent studies in the model plants Arabidopsis thaliana and rice have identified several key regulators building in response to the phytohormone auxin transcriptional networks that are involved in both callus formation and DNRR. In both cases, epigenetic regulation seems essential for the dynamic reprogramming of cell fate, which is correlated with local and global changes of the chromatin states that might ensure the correct spatiotemporal expression pattern of the key regulators. Future approaches might investigate in greater detail whether and how the transcriptional key regulators and the writers, erasers, and readers of epigenetic modifications interact to control DNRR.

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Section: Key Transcriptional Regulators Of Dnrrmentioning

confidence: 99%

Reprogramming of Cell Fate During Root Regeneration by Transcriptional and Epigenetic Networks

Jing

Ardiansyah

et al. 2020

Front. Plant Sci.

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“…The characteristics of the four Arabidopsis RING-finger proteins, AtRING1A, AtRING1B, AtBMI1A, and AtBMI1B, are consistent with their functioning like the mammalian PRC1 uibquitin ligase, which monoubiquitinates H2AK119 [8], [37]. EMF1 interacts with these proteins, and is required for these RING-finger proteins' monoubiquitination of H2AK119 (H2Aub), thus implicating EMF1 in PRC1 activity.…”

Section: Discussionmentioning

confidence: 62%

EMF1 and PRC2 Cooperate to Repress Key Regulators of Arabidopsis Development

et al. 2012

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EMBRYONIC FLOWER1 (EMF1) is a plant-specific gene crucial to Arabidopsis vegetative development. Loss of function mutants in the EMF1 gene mimic the phenotype caused by mutations in Polycomb Group protein (PcG) genes, which encode epigenetic repressors that regulate many aspects of eukaryotic development. In Arabidopsis, Polycomb Repressor Complex 2 (PRC2), made of PcG proteins, catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3) and PRC1-like proteins catalyze H2AK119 ubiquitination. Despite functional similarity to PcG proteins, EMF1 lacks sequence homology with known PcG proteins; thus, its role in the PcG mechanism is unclear. To study the EMF1 functions and its mechanism of action, we performed genome-wide mapping of EMF1 binding and H3K27me3 modification sites in Arabidopsis seedlings. The EMF1 binding pattern is similar to that of H3K27me3 modification on the chromosomal and genic level. ChIPOTLe peak finding and clustering analyses both show that the highly trimethylated genes also have high enrichment levels of EMF1 binding, termed EMF1_K27 genes. EMF1 interacts with regulatory genes, which are silenced to allow vegetative growth, and with genes specifying cell fates during growth and differentiation. H3K27me3 marks not only these genes but also some genes that are involved in endosperm development and maternal effects. Transcriptome analysis, coupled with the H3K27me3 pattern, of EMF1_K27 genes in emf1 and PRC2 mutants showed that EMF1 represses gene activities via diverse mechanisms and plays a novel role in the PcG mechanism.

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“…Thus, PcG and trxG antagonistically ensure the correct spatial and temporal expression of developmental regulators, such as those involved in flowering-time and flower development [13][14][15][16][17]. As a consequence, H3K27me3 and H3K4me3 chromatin marks should be highly dynamic throughout developmental stages and cell-types in plants.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of H3K4me3 Chromatin Marks Prevails over H3K27me3 for Gene Regulation during Flower Morphogenesis in Arabidopsis thaliana

et al. 2017

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Plant lifelong organogenesis involves sequential, time and tissue specific expression of developmental genes. This requires activities of Polycomb Group (PcG) and trithorax Group complexes (trxG), respectively responsible for repressive Histone 3 trimethylation at lysine 27 (H3K27me3) and activation-related Histone 3 trimethylation at lysine 4 (H3K4me3). However, the genome-wide dynamics in histone modifications that occur during developmental processes have remained elusive. Here, we report the distributions of H3K27me3 and H3K4me3 along with expression changes, in a developmental series including Arabidopsis thaliana leaf and three stages of flower development. We found that chromatin mark levels are highly dynamic over the time series on nearly half of all Arabidopsis genes. Moreover, during early flower morphogenesis, changes in H3K4me3 prevail over changes in H3K27me3 and quantitatively correlate with expression changes, while H3K27me3 changes occur later. Notably, we found that H3K4me3 increase during the early activation of PcG target genes while H3K27me3 level remain relatively constant at the locus. Our results reveal that H3K4me3 predicts changes in gene expression better than H3K27me3, unveil unexpected chromatin mechanisms at gene activation and underline the relevance of tissue-specific temporal epigenomics.

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Sweet memories: epigenetic control in flowering

Cited by 14 publications

References 40 publications

Reprogramming of Cell Fate During Root Regeneration by Transcriptional and Epigenetic Networks

Reprogramming of Cell Fate During Root Regeneration by Transcriptional and Epigenetic Networks

EMF1 and PRC2 Cooperate to Repress Key Regulators of Arabidopsis Development

Dynamics of H3K4me3 Chromatin Marks Prevails over H3K27me3 for Gene Regulation during Flower Morphogenesis in Arabidopsis thaliana

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