Sweat tests in the newborn period.

Hardy, Judy; Davison, S H; Higgins, M U; Polycarpou, P N

doi:10.1136/adc.48.4.316

Cited by 27 publications

(12 citation statements)

References 2 publications

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“…A minimum of 48 hr is recommended because of a transient elevation in sweat electrolytes on the first day after birth. 10 After 48 hr, there is no reason to delay sweat testing in a neonate.…”

Section: Discussionmentioning

confidence: 99%

Sweat analysis proficiency testing for cystic fibrosis

LeGrys

2000

Pediatr. Pulmonol.

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Section: Discussionmentioning

confidence: 99%

Sweat analysis proficiency testing for cystic fibrosis

LeGrys

2000

Pediatr. Pulmonol.

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“…54 The CLSI guidelines permit sweat testing after 48 hours of age. Because CF NBS results are unlikely to be available before 48 hours, the threshold for sweat testing is more likely to be related to weight rather than age; infants weighing Ͻ2 kg are more likely to provide insufficient sweat for analysis (quantity not sufficient [QNS]).…”

Section: Minimum Age and Weight Of The Infant For Valid Sweat Testingmentioning

confidence: 99%

Guidelines for Implementation of Cystic Fibrosis Newborn Screening Programs: Cystic Fibrosis Foundation Workshop Report

et al. 2007

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Newborn screening for cystic fibrosis offers the opportunity for early intervention and improved outcomes. This summary, resulting from a workshop sponsored by the Cystic Fibrosis Foundation to facilitate implementation of widespread high quality cystic fibrosis newborn screening, outlines the steps necessary for success based on the experience of existing programs. Planning should begin with a workgroup composed of those who will be responsible for the success of the local program, typically including the state newborn screening program director and cystic fibrosis care center directors. The workgroup must develop a screening algorithm based on program resources and goals including mechanisms available for sample collection, regional demographics, the spectrum of cystic fibrosis disease to be detected, and acceptable failure rates of the screen. The workgroup must also ensure that all necessary guidelines and resources for screening, diagnosis, and care be in place prior to cystic fibrosis newborn screening implementation. These include educational materials for parents and primary care providers; systems for screening and for providing diagnostic testing and counseling for screen-positive infants and their families; and protocols for care of this unique population. This summary explores the benefits and risks of various screening algorithms, including complex situations that can occur involving unclear diagnostic results, and provides guidelines and sample materials for state newborn screening programs to develop and implement high quality screening for cystic fibrosis.

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“…Sweat chloride tests are falsely elevated in the fi rst 24 h after birth, but rapidly decline thereafter [ 48 ] allowing for adequate sweat chloride collection after the fi rst 2 weeks of infancy as a general rule.…”

Section: Sources Of Errormentioning

confidence: 98%

Functional Evaluation of Cystic Fibrosis Transmembrane Conductance Regulator

Solomon

Rowe

2014

Diagnostic Tests in Pediatric Pulmonology

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Cystic fi brosis is caused by mutations in the cystic fi brosis transmembrane regulator (CFTR) gene which encodes an epithelial anion channel and regulatory protein. Derangements of CFTR protein function result in thickened, viscous mucus in the airways, GI tract, pancreas, sweat gland, and reproductive tract. The diagnosis and prognosis of CF is facilitated by demonstrating functional decrements of CFTR activity, and is a cornerstone of the diagnostic criteria. This chapter details the conduct and interpretation of the two most widely available diagnostic tests for CFTR functional analysis: sweat chloride testing and nasal potential difference (NPD). Details regarding the methods for conduct of these tests, sources of error, and emerging results supporting their interpretation are discussed.

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Sweat tests in the newborn period.

Cited by 27 publications

References 2 publications

Sweat analysis proficiency testing for cystic fibrosis

Sweat analysis proficiency testing for cystic fibrosis

Guidelines for Implementation of Cystic Fibrosis Newborn Screening Programs: Cystic Fibrosis Foundation Workshop Report

Functional Evaluation of Cystic Fibrosis Transmembrane Conductance Regulator

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