Swarming motility in host defense

Rocha-Gregg, Briana L; Huttenlocher, Anna

doi:10.1126/science.abj3065

Cited by 6 publications

(8 citation statements)

References 14 publications

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“…Likewise, innate immune disorders also are believed to play an important role in T1D [43]. Neutrophils are a key role in innate immunity, and our results also revealed that biological processes closely related to neutrophil functions like degranulation, clustering, chemotaxis, and movement such as calcium signaling pathway, G protein, protein phosphorylation, and so on are involved in the pathogenesis of in sJIA and T1D [44]. Therefore, the roles of neutrophils warrants further investigation.…”

Section: Discussionsupporting

confidence: 55%

Exploration of Common Genomic Signatures of Systemic Juvenile Rheumatoid Arthritis and Type 1 Diabetes

Zheng

2022

Preprint

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Objective To explore the genetic characteristics of systemic juvenile rheumatoid arthritis (sJIA) and type 1 diabetes mellitus (T1D). Methods The microarray data of sJIA and T1D from Gene Expression Omnibus (GEO) were analyzed. The shared differentially expressed genes (SDEGs) were identified by the GEO2R tool, and genes of extracellular proteins were identified. Then, weighted gene co-expression network analysis (WGCNA) was used to identify the shared immune-related genes (IRGs) that are associated with pJIA and T1D. In addition, transcription factors (TFs) and their target genes in SDEGs were obtained by comparing databases from HumanTFDB, ENCODE, JASPAR, and TRRUST. Finally, functional enrichment analyses of the previously identified gene sets were performed by g: Profiler. Results We found 285 up-regulated and 97 down-regulated SDEGs via GEO2R, and by constructing a TFs-targeted SDEGs network, 5 key TFs (KLF9, ARID3A, ZNF639, NEF2, MYB) were screened. Functional enrichment analyses of SDEGs, IRGs, and TFs-targeted SDEGs suggested the important role of the innate immune system, JAK-STAT and Ras-MAPK-ERK signaling pathways in the pathogenesis of sJIA and T1D, involving biological processes such as neutrophils and mononuclear cells, phosphorylation, transcellular signaling, and transferase activity, etc. Conclusion Innate immune abnormalities play important roles in sJIA and T1D, and the JAK-STAT and Ras-MAPK-ERK pathways, which are closely related to inflammation and immune regulation, may be involved. The regulatory roles of KLF9, ARID3A, ZNF639, NEF2, and MYB in this network need to be further investigated.

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Section: Discussionsupporting

confidence: 55%

Exploration of Common Genomic Signatures of Systemic Juvenile Rheumatoid Arthritis and Type 1 Diabetes

Zheng

2022

Preprint

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“… 1 , 2 , 6 , 8 Recent studies have illustrated a phenomenon called neutrophil swarming, a rapid focal accumulation of neutrophils mediated by intercellular communication that generates feedforward loops to coordinate neutrophil recruitment at local sites. 9 , 10 , 11 , 12 , 13 , 14 Neutrophil swarming has emerged as an important neutrophil response with implications for microbial infection, inflammation, immune regulation, tissue destruction and repair. The mechanisms underlying swarming have been the subject of several recent reviews.…”

Section: Introductionmentioning

confidence: 99%

Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase

Song,

Bhattacharya,

Clemens

et al. 2023

iScience

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“…Neutrophil production of LTB 4 and the release of another chemoattractant, chemokine CXCL2 (C-X-C motif chemokine ligand 2), is responsible for the collective coordinated behavior of neutrophils, called swarming, which is important for protection against severe pathogen infection ( Lammermann et al, 2013 ; de Oliveira et al, 2016 ; Rocha-Gregg and Huttenlocher 2021 ). During swarming hundreds of individual neutrophils respond with coordinated chemotaxis and self-amplified clusters formation.…”

Section: Introductionmentioning

confidence: 99%

Gram-Negative Bacteria Salmonella typhimurium Boost Leukotriene Synthesis Induced by Chemoattractant fMLP to Stimulate Neutrophil Swarming

et al. 2022

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Leukotriene synthesis in neutrophils is critical for host survival during infection. In particular, leukotriene B4 (LTB4) is a powerful neutrophil chemoattractant that plays a crucial role in neutrophil swarming. In this work, we demonstrated that preincubation of human neutrophils with Salmonella typhimurium strongly stimulated LTB4 production induced by the bacterial chemoattractant, peptide N-formyl-L-methionyl-L-leucyl-l-phenylalanine (fMLP), while the reverse sequence of additions was ineffective. Preincubation with bacterial lipopolysaccharide or yeast polysaccharide zymosan particles gives weaker effect on fMLP-induced LTB4 production. Activation of 5-lipoxygenase (5-LOX), a key enzyme in leukotrienes biosynthesis, depends on rise of cytosolic concentration of Ca2+ and on translocation of the enzyme to the nuclear membrane. Both processes were stimulated by S. typhimurium. With an increase in the bacteria:neutrophil ratio, the transformation of LTB4 to ω-OH-LTB4 was suppressed, which further supported increased concentration of LTB4. These data indicate that in neutrophils gathered around bacterial clusters, LTB4 production is stimulated and at the same time its transformation is suppressed, which promotes neutrophil swarming and elimination of pathogens simultaneously.

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Swarming motility in host defense

Abstract: Neutrophils exhibit self-control to resolve infection and tissue damage

Cited by 6 publications

References 14 publications

Exploration of Common Genomic Signatures of Systemic Juvenile Rheumatoid Arthritis and Type 1 Diabetes

Exploration of Common Genomic Signatures of Systemic Juvenile Rheumatoid Arthritis and Type 1 Diabetes

Molecular regulation of neutrophil swarming in health and disease: Lessons from the phagocyte oxidase

Gram-Negative Bacteria Salmonella typhimurium Boost Leukotriene Synthesis Induced by Chemoattractant fMLP to Stimulate Neutrophil Swarming

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