Swallowing Rehabilitation Using Chewing Gum Containing Capsaicin.

Umeno, Hirohito; Hamakawa, Sachiyo; Gondoh, Kyujirou; Shirouzu, Hidetaka; Yoshida, Yoshikazu; Nakashima, Tadashi

doi:10.2468/jbes.53.285

Cited by 4 publications

(1 citation statement)

References 3 publications

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“…Regarding substance P, a non-significant trend toward increased mRNA expression was observed, whereas immunohistochemistry revealed increased substance P expression particularly in the secretory granules of mucous glandular cells in the tongue epithelium of gingerstimulated mice. Capsaicin has been reported to promote the substance P secretion both in vitro and in vivo [15][16][17] , and significantly elevated saliva levels of substance P have been observed in humans after capsaicin administration in humans [18] . Our results support those from earlier reports.…”

Section: Discussionmentioning

confidence: 99%

Analysis of transient receptor potential vanilloid 1 and substance P gene expression in the mouse tongue following oral ginger administration

Michiro¹,

Ayumu²,

Noriaki³

et al. 2016

J Phytopharmacol

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Ginger rhizome (Zingiber officinale) exhibits multiple pharmacological actions. For example, its pungent components target the transient receptor potential vanilloid 1 (TRPV1) ion channel and thus contribute to swallowing reflex recovery by elevating the neuropeptide substance P. However, the precise mechanism underlying this action remains unclear. To examine TRPV1 and substance P gene expression in the mouse tongue in response to stimulation by orally administered ginger, quantitative real-time polymerase chain reaction and immunohistochemistry were performed to evaluate mRNA and protein expression. TRPV1 mRNA expression in the mouse tongue was upregulated 30 min after oral ginger stimulation. In the gingerstimulated mouse, TRPV1 protein expression was increased and concentrated in the plasma membranes of the mucous glandular cells of the tongue epithelium. No significant differences in substance P mRNA expression relative to the control were observed after ginger stimulation. However, immunohistochemistry revealed that the amount of substance P protein expression increased in the mucous glandular cells of the tongue epithelium in ginger-stimulated mice, and this expression appeared to concentrate in the secretory granules of these cells. Activation of TRPV1 promotes the secretion of substance P in saliva, and clinically, saliva levels of substance P can be measured noninvasively and can provide a useful biomarker of the swallowing function. An increased level of substance P in the saliva could indicate improved dysphagia. Our data suggest that ginger activates TRPV1 and promotes the secretion of substance P in saliva. Ginger is therefore expected to serve as a functional agent for improving dysphagia.

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Section: Discussionmentioning

confidence: 99%

Analysis of transient receptor potential vanilloid 1 and substance P gene expression in the mouse tongue following oral ginger administration

Michiro¹,

Ayumu²,

Noriaki³

et al. 2016

J Phytopharmacol

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The Swallowing Mechanism and Age-related Changes in Swallowing Function

Hyodo¹,

Nishikubo²,

Ameya³

et al. 2008

Jpn J Rehabil Med

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Cough reflex induced by capsaicin inhalation in patients with dysphagia

Imoto

Kojima²,

Osawa³

et al. 2010

Acta Oto-Laryngologica

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The control group showed a cough reflex at a capsaicin concentration of 2.61 μM (0.98-7.80), while patients with mild dysphagia did so at 7.28 μM (1.95-15.6), those with moderate dysphagia at 22.07 μM (15.6-62.5), and those with severe dysphagia at 71.75 μM (31.2-250). Control vs mild p < 0.01, control vs moderate p < 0.01, control vs severe p < 0.01, mild vs moderate p < 0.01, mild vs severe p < 0.01, moderate vs severe p < 0.05. There was a significant correlation between the grade of dysphagia and the threshold capsaicin concentration that provoked a cough reflex (ρ = -0.796, p < 0.001).

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Swallowing Rehabilitation Using Chewing Gum Containing Capsaicin.

Cited by 4 publications

References 3 publications

Analysis of transient receptor potential vanilloid 1 and substance P gene expression in the mouse tongue following oral ginger administration

Analysis of transient receptor potential vanilloid 1 and substance P gene expression in the mouse tongue following oral ginger administration

The Swallowing Mechanism and Age-related Changes in Swallowing Function

Cough reflex induced by capsaicin inhalation in patients with dysphagia

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