Swallowing dysfunction—preventative and rehabilitation strategies in patients with head-and-neck cancers treated with surgery, radiotherapy, and chemotherapy: A critical review

Mittal, Bharat B.; Pauloski, Barbara Roa; Haraf, Daniel J.; Pelzer, Harold J.; Argiris, Athanassios; Vokes, Everett E.; Rademaker, Alfred; Logemann, Jerilyn A.

doi:10.1016/s0360-3016(03)01454-8

Cited by 192 publications

(153 citation statements)

References 105 publications

Supporting

Mentioning

135

Contrasting

Unclassified

Order By: Relevance

“…Oral pain, mouth sores, taste changes, oral dryness, and loss of appetite have previously been reported as side effects which heighten awareness of functional swallowing difficulties (42,43). Longterm xerostomia has been postulated as impacting on functional swallowing by decreasing bolus lubrication, and increasing bolus transit time (34), and has been reported by over 90% of the current cohort.…”

Section: Discussionmentioning

confidence: 80%

“…The long-term deficits in swallowing function observed following definitive non-surgical treatment for HNC have been attributed to late treatment effects including tissue atrophy, oedema, and fibrosis (32)(33)(34). Hence the reason for deterioration in toxicity and subsequent impact on functional swallowing and weight in the current cohort may be the result of similar late or chronic effects of the AFRT-CB protocol.…”

Section: Discussionmentioning

confidence: 94%

“…While there may be an absence of data specifically relating to the AFRT-CB protocol outcomes at 2 years post-treatment, results from other definitive non-surgical treatment regimens have reported an ongoing functional impact on swallowing and nutrition long-term post-treatment (31)(32)(33)(34)(35). Studies have found that between 5 and 50% of participants are able to tolerate a full diet without restrictions at 1-2 years post-treatment with previously examined radiotherapy protocols for HNC (17, [36][37][38].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Long-term Functional Outcomes and Patient Perspective Following Altered Fractionation Radiotherapy with Concomitant Boost for Oropharyngeal Cancer

et al. 2012

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term Functional Outcomes and Patient Perspective Following Altered Fractionation Radiotherapy with Concomitant Boost for Oropharyngeal Cancer

et al. 2012

View full text Add to dashboard Cite

show abstract

“…For advanced cases, there has been a shift from surgical treatment towards chemoradiotherapy protocols (especially concomitant chemotherapy and radiotherapy, CRT). These organ preservation protocols, developed to maintain organ anatomy [6][7][8][9][10][11][12], unfortunately do not necessarily preserve the organ's function [5,6,10,13,14]. The toxicities of these combined therapies are often severe and include xerostomia, pain, mucositis, fatigue, as well as late eVects such as limited mouth opening (trismus) [15,16].…”

Section: Introductionmentioning

confidence: 99%

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

Molen

Rossum

Burkhead

et al. 2008

Eur Arch Otorhinolaryngol

109

View full text Add to dashboard Cite

Organ preservation with radiotherapy and concomitant chemotherapy has become an accepted treatment modality in advanced head and neck cancer. Unfortunately, organ preservation is not synonymous with function preservation. The aim of this review was to systematically assess the eVects of the disease and chemoradiotherapy (CRT) on functions such as swallowing, mouth opening, nutrition, pain and quality of life in patients with head and neck cancer. Another aim was to search for (evidence-based) techniques or strategies known to alleviate or rehabilitate the loss of function(s) associated with CRT. Two databases were searched (time period, January 1997 to August 2007) for the terms head and neck cancer, chemotherapy or cisplatin and radiotherapy, and the functional outcomes swallowing, trismus, nutrition, pain and quality of life or a variation of those words. In total, 15 relevant articles were identiWed that met the inclusion criteria. The majority of the studies that met the criteria focused on the outcomes swallowing, quality of life, and nutrition. Two studies reported on the outcome pain, but no paper reported on the outcome trismus. Only two papers mentioned rehabilitation options, but speciWc information was lacking. Further long-term prospective research is essential, not only to determine the function impairment caused by the tumor and CRT, but also to assess the eVects of known and newly developed rehabilitation measures. Therefore, in September 2006, the Netherlands Cancer Institute started a randomised clinical trial (RCT): Prevention of trismus, swallowing and speech problems in patients treated with chemoradiotherapy for advanced head and neck cancer. This systematic review was carried out to collect the baseline information for the future outcomes of this RCT.

show abstract

“…It is believed that dysphagia can be partially avoided or treated with exercises [47,48]. Little evidence supports this belief [49] however.…”

Section: Dysphagiamentioning

confidence: 99%

Measuring side effects after radiotherapy for pharynx cancer

Jensen

2007

Acta Oncologica

View full text Add to dashboard Cite

Swallowing dysfunction—preventative and rehabilitation strategies in patients with head-and-neck cancers treated with surgery, radiotherapy, and chemotherapy: A critical review

Cited by 192 publications

References 105 publications

Long-term Functional Outcomes and Patient Perspective Following Altered Fractionation Radiotherapy with Concomitant Boost for Oropharyngeal Cancer

Long-term Functional Outcomes and Patient Perspective Following Altered Fractionation Radiotherapy with Concomitant Boost for Oropharyngeal Cancer

Functional outcomes and rehabilitation strategies in patients treated with chemoradiotherapy for advanced head and neck cancer: a systematic review

Measuring side effects after radiotherapy for pharynx cancer

Contact Info

Product

Resources

About