The reconstruction of extended tumor-related defects in different anatomic regions requires a versatile and reliable flap. For many surgeons, the lateral arm flap has become the technique of choice in the reconstruction of small- to medium-sized defects. The aim of this study was to analyze the reconstructive potential of the lateral arm flap after cancer ablation in various indications. Between 1998 and 2006, 14 patients underwent reconstruction with differently composed and designed lateral arm flaps at our institution. Complete coverage of all defects was achieved with a single surgical procedure. With a flap survival rate of 100% in our series, excellent long term results and high patient satisfaction combined with low donor site morbidity, we can recommend the use of the lateral arm flap in tumor patients.