SVF cell sheets: A new multicellular material-based strategy for promoting angiogenesis and regeneration in diced cartilage grafts
Yangchen Wei,
Yi Wei,
Cong Xie
et al.
Abstract:Autologous diced cartilage, while biocompatible and easy to shape, is limited in clinical application due to its high resorption rate and challenges in establishing timely and effective neovascularization post-surgery. In this study, we produced SVF cell sheets from adipose-derived stromal vascular fraction (SVF) via enzymatic digestion, employing a temperature-sensitive culture system. Our in vivo and in vitro experiments validated that SVF cell sheets, when wrapped around granular cartilage, exhibited a nota… Show more
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