sVCAM-1, and TGFβ1 in chronic phase, chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Hammed, Muhamad R Abdel; Ahmed, Yoseryeia A; Adam, Esraa N; Bakry, Rania; Elnaggar, Mohamed

doi:10.55133/eji.290416

Cited by 11 publications

(13 citation statements)

References 20 publications

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“…No secondary transmission was recorded because of the deployment of notable IPC measures in an already activated EOC on Response mode. The elaborate public health interventions described in this case also show that management of Mpox disease in a manner as to prevent disease spread is quite laborious and resource demanding [19]. It requires skill, logistics and infrastructural capacity to enable preparedness using the PHEOC to achieve containment.…”

Section: Discussion On Mpox Case Reportmentioning

confidence: 93%

“…TGF-β1 suppresses the functions of Th1 and Th2, NK cells, and CD4+ effector cells, and promotes generation of Treg cells. While promotion of immune responses; TGF-β1 induces the generation of Th1 cells in combination with IL-6 [19]. IL-10 is an immune-regulatory cytokine having anti-tumor effect [20].…”

Section: In Combatting Monkeypox Infections Cd4 + T Cells Are Complex...mentioning

confidence: 99%

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Monkeypox Disease with Predominant Genital Symptoms: A Nigerian Case Report

Owhonda¹,

Wali

Nwadiuto³

et al. 2023

ACRI

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Mpox presents typically with macular papular body rashes with similar-looking sores in genital or oral areas. It may be missed, or wrongly managed as sexually transmitted infections (STI), especially in settings where symptom-based treatment practices are sufficient for care. We describe a 40-year-old cisgender male, heterosexual Nigerian who developed some rash in the genital region associated with penile swelling. It was suspected to be syphilis and managed with presumptive antibiotics. Laboratory investigation (PCR) confirmed that it was a Mpox disease, and VDRLT was negative. Notably, in this case, the early symptoms were a paradigm case of Mpox disease presenting as an STI, which syndromically conformed more to an STI than the case definition for a suspected case of Mpox in our setting. Consequently, the expected early containment activities were delayed. This increased the potential of further disease spread. An Update of the standard case definition as well as a reclassification of the disease as a possible STI is recommended for enhanced surveillance, increased case detection, and reduction in the burden of unrecognized cases.

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Section: Discussion On Mpox Case Reportmentioning

confidence: 93%

Section: In Combatting Monkeypox Infections Cd4 + T Cells Are Complex...mentioning

confidence: 99%

Monkeypox Disease with Predominant Genital Symptoms: A Nigerian Case Report

Owhonda¹,

Wali

Nwadiuto³

et al. 2023

ACRI

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“…7 Plasma levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), and transforming growth factor beta 1 (TGFβ1) are considered as predictors of hematological and molecular responses to TKIs in CML patients. 8 Also, interleukin 10 (IL-10) is a predictors of hematological and molecular responses to in CML patients and also, associated with advanced stage of multiple myeloma. 9,10 Tuberculosis (TB) and hepatitis C virus (HCV) coinfected patients showed higher serum levels of IL-10.…”

Section: Introductionmentioning

confidence: 99%

Kinetic of liver enzymes and serum electrolytes in HCV, HBV, and HIV negative chronic phase chronic myeloid leukemia patients treated with imatinib or nilotinib

Hammed

Nafady

Mohamed

et al. 2023

EJI

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The outcome for chronic phase (CP) chronic myeloid leukemia (CML) patients was changed dramatically since the introduction of tyrosine kinase inhibitor (TKI) therapy. This study intended to evaluate side effects of TK Imatinib or Nilotinib on liver enzymes and serum electrolytes in relation to hematologic and molecular response in HCV-, HBV-, and HIV-, CP-CML patients. The study was a quasi-experimental pre-post single group design, included 38 HCV-, HBV-, and HIV-newly diagnosed Philadelphia positive CP-CML patients with normal hepatic and renal function. They were divided equally into two groups, 19 received Nilotinib, and 19 received Imatinib. Hematologic, BCR-ABL gene expression by RT-PCR, electrolytes and liver enzymes were measured at baseline and after 6 months of treatment. Patients age ranged between 20 and 62 years. Anemic manifestations represented the highest rate (n=23, 60.5%). The mean WBCs count was significantly reduced after treatment (p<0.001). The WBCs count was significantly reduced in the Nilotinib group than the Imatinib group (97% and 94%, respectively, p=0.049). The mean hemoglobin level was significantly increased after treatment (p=0.010). The mean platelet level did not change over the treatment period. The mean AST, ALT, and ALP levels were significantly increased after treatment, (p=0.014, p=0.002, and p=0.047, respectively). The ALP level was significantly increased in both groups (p=0.001). The mean sodium potassium, phosphorous, and calcium level was not changed over the treatment period. The mean BCR-ABL gene expression was sharply decreased after treatment (p<0.001). A higher reduction was observed in the Nilotinib group (99%) than the Imatinib group (91.5%) (p=0.025). Imatinib resulted in rise of AST and ALP levels than Nilotinib, while both had the same effect on the ALT level. Higher reduction in BCR-ABL gene expression was achieved by Nilotinib. Nilotinib and Imatinib did not affect serum levels of sodium, potassium, phosphorous, or calcium.

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“…Also, it is associated with advanced stage of multiple myeloma patients 4 . VCAM‐1 is a cytokine‐inducible endothelial cell adhesion molecule (CAM) 5 and considered as a sensitive prognostic marker in CLL patients and significantly correlates with tumor burden 6 . The mutational status of the immunoglobulin heavy variable region ( IGHV ) gene is one of the most powerful prognostic factors 7 .…”

Section: Introductionmentioning

confidence: 99%

Molecular characteristics in Chinese with chronic lymphocytic leukemia by next‐generation sequencing: A single‐center retrospective analysis

Cao

Chen

Tao

et al. 2023

Int J Lab Hematology

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IntroductionAlthough the prevalence of Asian chronic lymphocytic leukemia (CLL) patients is not as high as that of Caucasians, there are more atypical CLLs in Asia whose genetic characteristics and their clinical significance are distinct and remain unclear.MethodsA retrospective analysis of 85 CLL samples in our center was conducted from 2019 to 2022. We used next‐generation sequencing with a 172 gene panel to explore the multi‐gene mutational data and the mutational status of immunoglobulin heavy variable (IGHV) gene.ResultsMYD88 (20.0%) was the most frequently mutated gene, much higher than in Europe, followed in order by TP53 (18.8%), NOTCH1 (14.1%), IGLL5 (11.8%), and DNMT3A (8.2%). In addition, the incidence of ATM and SF3B1 mutations was relatively lower in our centre compared to Europe. Mutated (M)‐IGHV patients were more likely to have a cooccurrence of MYD88 mutation, while complex karyotype and DNMT3A mutation were more common in the unmutated (U)‐IGHV group. MYD88 mutated CLL was characterized by prevalence in young males in high‐risk staging, with isolated 13q deletion and concomitant mutation of IGLL5. CLL patients with MYD88 and TP53 mutation showed an unfavorable prognosis.ConclusionThese results would be valuable in helping to understand the characteristics and significance of cytogenetic genetics in Chinese patients with CLL.

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sVCAM-1, and TGFβ1 in chronic phase, chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Cited by 11 publications

References 20 publications

Monkeypox Disease with Predominant Genital Symptoms: A Nigerian Case Report

Monkeypox Disease with Predominant Genital Symptoms: A Nigerian Case Report

Kinetic of liver enzymes and serum electrolytes in HCV, HBV, and HIV negative chronic phase chronic myeloid leukemia patients treated with imatinib or nilotinib

Molecular characteristics in Chinese with chronic lymphocytic leukemia by next‐generation sequencing: A single‐center retrospective analysis

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