SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice

Abstract

SV40 T antigen remarkably targeted the cell metabolism and disrupted the balance between proliferation and apoptosis during the lens carcinogenesis and following progression.

Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas

“…The 200 amino acid C-terminal segment of parafibromin shares 32% identity and 54% homology with Cdc73, a Saccharomyces cerevisiae protein forming the Paf1 complex, which is associated with RNA polymerase II and involved in transcript site selection, transcriptional elongation, histone H2B ubiquitination, histone H3 methylation, poly (A) length control, and the coupling of transcriptional and posttranscriptional events. Parafibromin overexpression inhibits colony formation and cellular proliferation and induces cell cycle arrest at G1, indicating that parafibromin has a critical role in cell growth [18,36]. In the present study, expression of parafibromin was positively correlated with nuclear, but not cytoplasmic, Bag-1.…”

The clinicopathological significances and biological functions of parafibromin expression in head and neck squamous cell carcinomas

“…Previously, Iwata et al [11] reported that parafibromin enhanced cell growth in 293FT cells expressing SV40 large T antigen. In transgene mice of SV40 T antigen, the persistent parafibromin expression was observed since the lens carcinogenesis [30]. In combination of these results, we speculated that parafibromin expression might be essential for HPV infection in HNSCCs or suppress the DNA synthesis of HPV as a feedback overexpression.…”

Parafibromin expression is an independent prognostic factor for colorectal carcinomas

“…Results are representative of 3 different experiments, and data are expressed as mean ± SD. appeared at the edges of the parathyroid or animal lens tumors, or around blood vessels [23,30]. Therefore, we exposed parafibromin-strongest SW480 cells under hypoxia and/or serum-free medium, but found no alteration of parafibromin expression after treatment until 48 hours.…”