Suxamethonium—A Review: Part II—Neuromuscular Blocking Properties

Gibb, David

doi:10.1177/0310057x7300100301

Cited by 4 publications

(1 citation statement)

References 98 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many host factors have been shown to influence the incidence of postsuxamethonium myalgia [ 1,9]. The incidence is lower at the extremes of life whilst males have a lower incidence than females.…”

Section: Discussionmentioning

confidence: 99%

Suxamethonium myalgia: an ethnic comparison with and without pancuronium pretreatment

Houghton¹,

Aun²,

Gin³

et al. 1993

Anaesthesia

View full text Add to dashboard Cite

SummaryThe incidence of myalgia after suxamethonium was determined in 2OOJit military male dental patients of European, Chinese and Nepalese descent. H a y received pancuronium I mg and the other h a y received saline pretreatment on a randomised double-blind basis. The percentage incidence of postsuxamethonium myalgia after saline or pancuronium was found to be: Europeans 26%, 13%; Chinese 13%, 7%; Nepalese 20%, 14%. Although pancuronium reduced the incidence of myalgia by about 50% overall, these values were not significantly direrent .from each other. The recovery of spontaneous ventilation following suxamethonium was quicker in the Europeans than in the Asians ( p < 0.05). Pancuronium pretreatment also delayed the recovery of spontaneous ventilation and recovery from neuromuscular block ( p < 0.05) but this was independent of ethnicity. The Europeans recovered from anaesthesia more quickly than the Asians. It was concluded that ethnicity affected recovery from suxamethoniurn and from anaesthesia but was not of clinical relevance to the incidence of myalgia in male Asians and Europeans.

show abstract

Section: Discussionmentioning

confidence: 99%

Suxamethonium myalgia: an ethnic comparison with and without pancuronium pretreatment

Houghton¹,

Aun²,

Gin³

et al. 1993

Anaesthesia

View full text Add to dashboard Cite

show abstract

Drug Interactions in Anaesthesia

Gibb¹

1984

Clinics in Anaesthesiology

View full text Add to dashboard Cite

Diazepam Does Not Prevent Succinylcholine‐Induced Fasciculations and Myalgia: A Comparative Evaluation of the Effect of Diazepam and d‐Tubocurarine Pretreatments

Manchikanti

1984

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

To determine the effectiveness of diazepam pretreatment in preventing succinylcholine (SCh)-induced fasciculations and body pains, 587 patients were randomly allocated to six groups. Patients in Group I received no pretreatment and served as controls. Patients in Groups II and III were pretreated with 0.05 mg/kg of diazepam either 4-5 min (Group II) or 8-10 min (Group III) prior to SCh administration. Patients in Groups IV and V received 0.1 mg/kg of diazepam either 4-5 min (Group IV) or 8-10 min (Group V) prior to SCh administration, while patients in Group VI were pretreated with 0.05 mg/kg of d-tubocurarine (dTc) 4-5 min prior to SCh. The succinylcholine dosage was 1.0 mg/kg in Groups I through V and 1.5 mg/kg in Group VI. Fasciculations, intubation conditions and postoperative body pains were evaluated in all groups. Fasciculations were seen in 90% of patients in the control group and 15% in the dTc pretreatment group, while diazepam was ineffective in altering the frequency or intensity of fasciculations. Conditions for intubation were judged to be clinically adequate in all groups. Body pains were seen in 33% of patients in the control group and 28-36% in diazepam-pretreated groups and in only 8% of patients in the dTc pretreatment group. There was no statistically significant difference in the incidence of body pains by virtue of site of operation, age, sex, and inpatient/outpatient status. It is concluded that the problem of postoperative myalgia is significant and that dTc pretreatment is the effective method for prevention of fasciculations and postoperative myalgia. Diazepam pretreatment was ineffective for the prevention of fasciculations and myalgia.

show abstract

Suxamethonium—A Review: Part II—Neuromuscular Blocking Properties

Cited by 4 publications

References 98 publications

Suxamethonium myalgia: an ethnic comparison with and without pancuronium pretreatment

Suxamethonium myalgia: an ethnic comparison with and without pancuronium pretreatment

Drug Interactions in Anaesthesia

Diazepam Does Not Prevent Succinylcholine‐Induced Fasciculations and Myalgia: A Comparative Evaluation of the Effect of Diazepam and d‐Tubocurarine Pretreatments

Contact Info

Product

Resources

About