SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer

Doi, Hiroshi; Kitajima, Kazuhiro; Fukushima, Kazuhito; Kawanaka, Yusuke; Mouri, Miya; Yamamoto, Satoshi; Ishikura, Reiichi; Terada, Tomonori; Noguchi, Kazuma; Hirota, Shun

doi:10.1007/s11604-016-0531-9

Cited by 10 publications

(79 citation statements)

References 11 publications

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“…Standardized uptake value (SUV), a semi-quantitative parameter in 18 F-FDG-PET/CT, is calculated as of the ratio of the FDG concentration to the weight-standardized injected dose in a region of interest (ROI) [9]. The most widely used parameter is SUV max , defined as the maximal SUV value in the ROI and is supposed to be a prognostic marker in some malignancies [6, 10–11]. Apart from SUV max , metabolic tumor volume (MTV) and total lesion glycolysis (TLG), as the tumor metabolic and volumetric parameter, are more widely applied in 18 F-FDG-PET/CT recently [12].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of 18F-FDG-PET/CT in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

et al. 2016

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BackgroundThe prognostic role of 18F-fluorodeoxyglucose positron emission tomography CT (18F-FDG PET/CT) parameters is still controversial in nasopharyngeal carcinoma patients. We sought to perform a systematic review and meta-analysis to explore the prognostic value of maximal standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) on event-free survival (EFS) and overall survival (OS) in nasopharyngeal carcinoma patients.ResultsFifteen studies comprising 1,938 patients were included in this study. The combined hazard ratios (HRs) for EFS were 2.63 (95%CI 1.71-4.05) for SUVmax, 2.55 (95%CI 1.49-4.35) for MTV, and 3.32 (95%CI 1.23-8.95) for TLG. The pooled HRs for OS were 2.07 (95%CI 1.54-2.79) for SUVmax, 3.86 (95%CI 1.85-8.06) for MTV, and 2.60 (95%CI 1.55-4.34) for TLG. The prognostic role of SUVmax, MTV and TLG remained similar in the sub-group analyses.MethodsA systematic literature search was performed to identify studies which associated 18F-FDG PET/CT to clinical survival outcomes of nasopharyngeal carcinoma patients. The summarized HRs for EFS and OS were estimated by using fixed- or random-effect models according to heterogeneity between trials.ConclusionsThe present meta-analysis confirms that high values of SUVmax, MTV and TLG predicted a higher risk of adverse events or death in patients with nasopharyngeal carcinoma, despite clinically heterogeneous nasopharyngeal carcinoma patients and the various methods adopted between these studies.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of 18F-FDG-PET/CT in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

et al. 2016

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“…These quantifiers have been used with F-18-FDG PET/CT, with the prognostic significance of different particular values reported across various tumor locations. [151617] In the present study, the MTV was identified as a prognostic factor for PFS, suggesting that it is the greater tumor volume that corresponds to poor disease outcome. Observations in line with this hypothesis have already been published for meningiomas; it must be noted that these studies did not use functional imaging (CT and MRI were performed).…”

Section: Discussionmentioning

confidence: 55%

The Prognostic value of pretreatment gallium-68 DOTATATE positron emission tomography/computed tomography in irradiated non-benign meningioma

Pelak

d’Amico

2019

Indian J Nucl Med

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Purpose of the study:The purpose of this study was to evaluate the potential value of gallium-68 (Ga-68)-DOTATATE positron emission tomography/computed tomography (PET/CT) in predicting the risk of progression in nonbenign meningioma after definite irradiation. We retrospectively reviewed our patients with meningiomas who had the highest risk of progression: WHO histological Grade II and III tumors and with macroscopic disease as identified in Ga-68-DOTATATE PET/CT.Materials and Methods:Thirteen patients were included in this study. For each tumor, the following quantifiers were measured: maximum and mean standardized uptake volume (SUV), standard deviation, metabolic tumor volume (MTV), total lesion activity, and coefficient of variation. Each of the quantifiers except for maximum SUV was obtained with three different SUV thresholds: muscle based (ms), liver based (liv), and gradient based (gb). The quantifiers were analyzed in univariate Cox model for their prognostic value for progression-free survival (PFS) and overall survival (OS).Results:Mean follow-up of the patients was 28.2 months. The 2-year PFS and OS was 28.1% and 76.9%, respectively. The MTVgb was a significant predictor for PFS (risk of progression of disease above vs. below the 34 cm3 threshold: 100% vs. 28.3%, P = 0.0003). Clinically, the male sex also influenced PFS (Hazard ratio =13.06; 95% confidence interval: 1.56–109.25; P = 0.018). The mean SUVms(P = 0.041) and SUVgb(P = 0.048) had a prognostic value for predicting the risk of death.Conclusion:Ga-68-DOTATATE PET/CT has potential to predict disease progression in nonbenign meningioma patients. Further prospective studies for validating and standardizing these findings are indicated.

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“…Doi et al 18 reported similar findings focusing on baseline PET/CT scan performed only in maxillary sinus cancer. The authors included 29 (93.5%) subjects with SCC in their study and concluded that SUVmax was significantly correlated with PFS and OS.…”

Section: Discussionmentioning

confidence: 60%

“…1 In this setting, their assessment is based on radiological evaluation with computed tomography (CT) and magnetic resonance (MR), which are pivotal for their correct evaluation. [8][9][10] In the last decades, however, use of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) has emerged as an important tool for the evaluation of SNC, given its ability to provide information on both metabolic activity and extension of disease. Furthermore, its role in demonstrating nodal and distant metastases has been extensively proved.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of baseline ¹⁸F‐FDG pet/CT in squamous cell carcinoma of the paranasal sinuses

et al. 2022

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Background To retrospectively investigate the prognostic role of baseline 18F‐FDG PET/CT in squamous cell carcinoma (SCC) of the paranasal sinuses. Methods Clinical features and PET/CT semiquantitative parameters of 49 patients were collected. Anova and Kruskall–Wallis tests were used to assess the relationship between these parameters. Kaplan–Meier, univariate, and multivariate analysis were performed to search for independent prognostic factors for progression free (PFS) and overall survival (OS). Results Mean PFS was 29.95 months (SD 29.36) with relapse/progression of disease occurring in 18 patients; mean OS was 33.40 (SD 27.78) months with death occurring in 15 patients. Presence of nodal metastasis (14 subjects) was correlated with standardize uptake value (SUV) max, SUVmean, SUV/blood‐pool ratio, SUV/liver ratio, metabolic tumor volume, and total lesion glycolysis. SUVmax, SUVmean, and presence of nodal metastasis resulted as independent prognostic factors for OS. Conclusion 18F‐FDG PET/CT semiquantitative parameters confirmed their prognostic role for SCC of paranasal sinuses.

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SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer

Abstract: SUVmax of the primary tumor determined by FDG-PET/CT before treatment could be a good surrogate marker for prognostication of maxillary sinus cancer.

Cited by 10 publications

References 11 publications

Prognostic value of 18F-FDG-PET/CT in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

Prognostic value of 18F-FDG-PET/CT in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

The Prognostic value of pretreatment gallium-68 DOTATATE positron emission tomography/computed tomography in irradiated non-benign meningioma

Prognostic role of baseline ¹⁸F‐FDG pet/CT in squamous cell carcinoma of the paranasal sinuses

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SUVmax on FDG-PET is a predictor of prognosis in patients with maxillary sinus cancer

Abstract: SUVmax of the primary tumor determined by FDG-PET/CT before treatment could be a good surrogate marker for prognostication of maxillary sinus cancer.

Cited by 10 publications

References 11 publications

Prognostic value of 18F-FDG-PET/CT in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

Prognostic value of 18F-FDG-PET/CT in patients with nasopharyngeal carcinoma: a systematic review and meta-analysis

The Prognostic value of pretreatment gallium-68 DOTATATE positron emission tomography/computed tomography in irradiated non-benign meningioma

Prognostic role of baseline 18F‐FDG pet/CT in squamous cell carcinoma of the paranasal sinuses

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Prognostic role of baseline ¹⁸F‐FDG pet/CT in squamous cell carcinoma of the paranasal sinuses