SUV<sub>max</sub>-based assessment of PET response shows a superior specificity to Deauville criteria for predicting recurrence in Hodgkin’s lymphoma

Texte, Edgar; Lequesne, Justine; Tilly, Hervé; Jardin, Fabrice; Véra, Pierre; Stamatoullas, Aspasia; Becker, Stéphanie

doi:10.1080/10428194.2020.1855341

Cited by 9 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre‐ASCT PET‐CT findings are critically important for identifying prognosis in patients with R/R cHL. 33 , 34 , 35 , 36 , 37 For example, a previous study revealed that the findings from PET scan images were associated with PFS in patients with R/R cHL, which is consistent with the data from our study. Here, the 5‐year PFS rates of patients who achieved CR or PR before ASCT were 73.69% and 49.07%, respectively, although the 5‐year PFS rates of patients with SD and PD were 30%.…”

Section: Discussionsupporting

confidence: 92%

“…In addition, our study focused on the prognostic significance of PET/CT results. Pre‐ASCT PET‐CT findings are critically important for identifying prognosis in patients with R/R cHL 33–37 . For example, a previous study revealed that the findings from PET scan images were associated with PFS in patients with R/R cHL, which is consistent with the data from our study.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Single or tandem autologous stem cell transplantation for treating Chinese patients with refractory/relapsed classical Hodgkin lymphoma

et al. 2023

View full text Add to dashboard Cite

Background Autologous stem cell transplantation (ASCT) is the standard treatment strategy for refractory or relapsed classical Hodgkin lymphoma (R/R cHL). However, a single transplantation is insufficient to cure the disease because of unfavorable risk factors. Herein, we evaluated the outcomes of single or tandem ASCT in patients with R/R cHL, especially in high‐risk patients. Methods We retrospectively analyzed R/R cHL patients who underwent single or tandem ASCT between April 2000 and June 2021 at the Beijing Cancer Hospital and Peking University International Hospital. Results A total of 134 patients were enrolled. Patients were allocated to a favorable‐risk group (group A, n = 33), an unfavorable‐risk group (group B, n = 81) that underwent single ASCT, and an unfavorable‐risk group that underwent tandem ASCT (group C, n = 20). The median follow‐up time was 99 months (range, 91–107 months), and no treatment‐related deaths occurred after single or tandem ASCT. However, 27 patients (2 in group C) died during the follow‐up period. The groups A, B, and C had 5‐year progression‐free survival (PFS) rates of 77.05%, 45%, and 74.67%, respectively (p = 0.0014), and 5‐year overall survival (OS) rates of 89.85%, 76.06%, and 95%, respectively (p = 0.18). Neither the median PFS rates of groups A and C nor the OS rates of all groups were reached. Conclusions Our study discusses the advantages of tandem transplantation for high‐risk patients with R/R cHL.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Single or tandem autologous stem cell transplantation for treating Chinese patients with refractory/relapsed classical Hodgkin lymphoma

et al. 2023

View full text Add to dashboard Cite

show abstract

“…First, the independence from the administered activity and body weight, overcoming the limits of other semi-quantitative parameters such as ΔSUVmax. Moreover, it allows the conversion of a visual qualitative scale (e.g., DS) to a continuous semi-quantitative one [ 23 , 24 ]. In addition, the definition of a semi-quantitative cutoff value simplifies the dichotomization of responder vs. no-responder patients at EoT-PET; however, caution should be made in the assessment of liver disease and diabetes, factors that may influence liver metabolism.…”

Section: Discussionmentioning

confidence: 99%

Lesion-to-Liver SUVmax Ratio to Improve the Prognostic Value of the End of Treatment PET/CT in Diffuse Large B-Cell Lymphoma

Ferrari

Pisani

Masi

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma worldwide. After first-line therapy, 30–40% of patients relapse or experiment with refractory disease. 18F-FDG PET/CT represents a validated diagnostic tool in post-treatment evaluation of FDG-avid lymphoma, and the Deauville Score (DS), a five-point visual scale, is usually used to assess response. However, the increased number of false positive findings suggested the need to search for new parameters. The aim of this study is to evaluate the prognostic value of End-of-Treatment-PET, comparing DS to the semi-quantitative Lesion-to-Liver ratio (LLR). Methods: newly diagnosed DLBCL patients who underwent 18F-FDG PET/CT were retrospectively analyzed. End-of-Treatment PET findings were assessed first using DS; secondly, assigned the LLR. Results: a total of 105 patients were finally enrolled. ROC analysis showed an LLR of 1.80 as the optimal cutoff value for predicting a disease progression (sensitivity 58%, specificity 95%). Both DS and LLR showed a statistically significant correlation with PFS and OS. LLR resulted in a better diagnostic performance than DS. Conclusions: LLR showed to be a reliable diagnostic method to assess treatment response in DLBCL. The integration of visual and semi-quantitative criteria could help in decision making, improving specificity and PPV.

show abstract

“…Moreover, their de nition of SUVpeak requires a dedicated software and is not measurable with standard workstations. It is not clear why the authors did not use SUVmax as a measure of residual uptake, as is common in other studies [17].…”

Section: Limitations Of the Studymentioning

confidence: 97%

Distribution and predictors of F-18-FDG uptake values of non-malignant cervical lymph nodes in pediatric patients

GODEFROY,

VEDDER

et al. 2024

Preprint

View full text Add to dashboard Cite

Background F-18-flurodeoxyglucose (FDG) PET/CT is routinely used for staging, evaluation of response to treatment and follow-up of most pediatric malignancies. Cervical lymph nodes can be involved in some pediatric malignancies, but increased uptake in non-malignant cervical lymph nodes is not exceptional in this population. The aim of the present study is to identify predictors of the maximum uptake in non-malignant cervical lymph nodes in the pediatric population. Methods 191 FDG PET/CT studies of pediatric patients without malignant involvement of cervical lymph nodes were retrospectively reviewed. The maximal Standard Uptake Value in the hottest cervical lymph node (SUVmaxCLN), as well as demographic, technical and imaging variables were recorded. The predictive effect of those variables on SUVmaxCLN was estimated using linear regression models. Results Increased FDG activity in cervical nodes was observed in 136/191 studies (71%). The mean SUVmaxCLN was 2.2 ± 1.3. Ipsilateral palatine tonsil SUVmax, mean liver uptake, and treatment status were all statistically significant predictors of SUVmaxCLN. However, in multivariate regression analysis, only ipsilateral palatine tonsil SUVmax was found to be significant. Conclusion SUVmax in ipsilateral palatine tonsil is a strong predictor of the maximal uptake value of non-malignant cervical lymph nodes in children. Trial was registered in the internal hospital registry under TRN 0209-22-HMO on date 23.04.2022.

show abstract

SUV_max-based assessment of PET response shows a superior specificity to Deauville criteria for predicting recurrence in Hodgkin’s lymphoma

Cited by 9 publications

References 21 publications

Single or tandem autologous stem cell transplantation for treating Chinese patients with refractory/relapsed classical Hodgkin lymphoma

Single or tandem autologous stem cell transplantation for treating Chinese patients with refractory/relapsed classical Hodgkin lymphoma

Lesion-to-Liver SUVmax Ratio to Improve the Prognostic Value of the End of Treatment PET/CT in Diffuse Large B-Cell Lymphoma

Distribution and predictors of F-18-FDG uptake values of non-malignant cervical lymph nodes in pediatric patients

Contact Info

Product

Resources

About

SUVmax-based assessment of PET response shows a superior specificity to Deauville criteria for predicting recurrence in Hodgkin’s lymphoma

Cited by 9 publications

References 21 publications

Single or tandem autologous stem cell transplantation for treating Chinese patients with refractory/relapsed classical Hodgkin lymphoma

Single or tandem autologous stem cell transplantation for treating Chinese patients with refractory/relapsed classical Hodgkin lymphoma

Lesion-to-Liver SUVmax Ratio to Improve the Prognostic Value of the End of Treatment PET/CT in Diffuse Large B-Cell Lymphoma

Distribution and predictors of F-18-FDG uptake values of non-malignant cervical lymph nodes in pediatric patients

Contact Info

Product

Resources

About

SUV_max-based assessment of PET response shows a superior specificity to Deauville criteria for predicting recurrence in Hodgkin’s lymphoma