Sutures versus new cyanoacrylates in prosthetic abdominal wall repair: a preclinical long-term study

Pascual, Gemma; Rodríguez, Marta; Mesa-Ciller, Claudia; Pérez-Köhler, Bárbara; Fernández-Gutiérrez, Mar; Román, Julio San; Bellón, Juan M.

doi:10.1016/j.jss.2017.06.074

Cited by 15 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The suitability of these tissue adhesives in the fixation of high-density PP prostheses has already been tested by different authors and by our group in previous preclinical studies [ 22 , 28 , 44 – 46 ], which showed proper fixation and effective biocompatibility. The main problem of the CAs has turned out to be the general increase in the macrophagic response with respect to the sutures.…”

Section: Discussionmentioning

confidence: 99%

“…In previous works, we tested the biological and mechanical effectiveness of high-density meshes fixed with cyanoacrylates, obtaining mechanical fixation results similar to those when fixing with sutures [ 22 ]. In the present experimental study, taking into account the advantages offered by the low-density prostheses and to solve the additional disadvantage of their difficult fixation with sutures to the recipient tissue due to its substantial porosity, which can lead to disinsertions of the material, we designed an assay using these meshes, fixing them with both conventional commercial and experimental cyanoacrylates.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

et al. 2018

Self Cite

View full text Add to dashboard Cite

IntroductionLightweight (LW) polypropylene (PP) meshes better adapt to host tissue, causing less fibrosis and inflammatory responses than high-density meshes. Mesh fixation using tissue adhesives (TA) that replace conventional sutures may improve the process of hernia repair and tissue trauma. This preclinical study compares the behavior of different cyanoacrylate-based adhesives in the fixation of LW-PP meshes for hernia repair.MethodsPartial abdominal wall defects were repaired using LW-PP Optilene meshes in New Zealand rabbits. The following groups were established according to the mesh fixation method: Suture (control), Glubran 2 (n-butyl), Ifabond (n-hexyl), SafetySeal (n-butyl) and Evobond (n-octyl). At 14, 90 and 180 days after surgery, the recovered implants were examined to assess the host tissue integration, the macrophage response and the biomechanical strength.ResultsAll the groups showed optimal host tissue incorporation regardless of the fixation procedure. Significantly increased levels of collagen 1 and collagen 3 gene expression (p<0.001) were observed at 14 days compared to the medium- and long-term durations, where the Suture and Glubran groups showed the highest expression of collagen 1. All the adhesives increased the macrophage reaction (p<0.001) compared to sutures at all implant times. Maximal macrophage response was observed in the short-term Glubran group (p<0.01) compared to the rest of the groups. Although SafetySeal and Evobond did not reach the biomechanical resistance of sutures at 14 days, all the adhesives did reach this level in the medium- to long-term periods, providing significantly higher resistance (p<0.05).ConclusionsAll the cyanoacrylates, despite inducing a significantly increased macrophage response versus sutures, showed optimal host tissue integration and long-term mechanical behavior; thus, they might be good choices for LW-PP mesh hernia repairs.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Depending on the desired application, there may be different performance criteria that the bioadhesive needs to satisfy. For example, Pascual et al reported that abdominal wall repair using a surgical mesh required a fixation strength of 55–60 N and the cyanoacrylate‐based adhesive was equally as successful as suture fixation. Sutures have a high tensile strength (8–15 N) and require a minimal footprint for repair.…”

Section: Key Criteria For Biomedical Adhesive Designmentioning

confidence: 99%

Multifunctional Biomedical Adhesives

Pinnaratip

Bhuiyan

Meyers

et al. 2019

Adv Healthcare Materials

143

View full text Add to dashboard Cite

Currently available biomedical adhesives are mainly engineered to have one function (i.e., providing mechanical support for the repaired tissue). To improve the performance of existing bioadhesives and broaden their applications in medicine, numerous multifunctional bioadhesives are reported in the literature. These adhesives can be categorized as passive or active by design. Passive multifunctional bioadhesives contain inherent compositions and structural designs that can carry out additional functions without added external influences. These adhesives exhibit new functionalities such as antimicrobial properties, self‐healing abilities, the ability to promote cellular ingrowth, and the ability to be reshaped. Conversely, active multifunctional bioadhesives respond to environmental changes (e.g., pH, temperature, electricity, light, and biomolecule concentration), which initiate a change in the adhesive to release encapsulated drugs or to activate or deactivate the bioadhesive for interfacial binding. This review article highlights recent advances in multifunctional bioadhesives.

show abstract

“…Bioadhesives have advantages over sutures, which are often associated with chronic pain, prolonged surgical time, fluid leakage, and compliance mismatch . Unlike sutures that require minimal footprint for repair, bioadhesives require increased overlapped surface area between the adhesive and the substrates to achieve equivalent fixation strength . As such, prolonged presence of the adhesive can act as a barrier to the union of wound edges.…”

Section: Introductionmentioning

confidence: 99%

Correlating the mass and mechanical property changes during the degradation of PEG‐based adhesive

Zhang

Pinnaratip

Ong

et al. 2019

J of Applied Polymer Sci

View full text Add to dashboard Cite

Change in mechanical property of a degrading adhesive is critical to its performance. However, characterization of degradation behavior is often limited to tracking its mass loss. Four-armed poly(ethylene glycol) end modified with dopamine (PEG-DA) was used as a model bioadhesive to correlate its change in mass with change in mechanical property. Shear modulus (G) was calculated based on the mass and average molecular weight between crosslinks ( M c ) of PEG-DA, while the storage modulus (G 0 ) was determined by oscillatory rheometry. G decreased slowly within the first week of degradation (4% reduction by week 2), while G 0 decreased by 60% during the same period. This large discrepancy is due to the partially disconnected and elastically ineffective PEG polymer, which is trapped within the adhesive network. This resulted in minimal mass change and higher calculated G value during the earlier time points. Therefore, tracking mass loss profile alone is inadequate to completely describe the degradation behavior of an adhesive. Additionally, PEG-DA was coated onto magnetoelastic (ME) sensors, and the change in the resonance amplitude of the sensor corresponded well with dry mass loss of PEG-DA. ME sensing provides a nondestructive method to track the mass loss of the coated adhesive.

show abstract

Sutures versus new cyanoacrylates in prosthetic abdominal wall repair: a preclinical long-term study

Cited by 15 publications

References 19 publications

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

Pre-clinical assay of the tissue integration and mechanical adhesion of several types of cyanoacrylate adhesives in the fixation of lightweight polypropylene meshes for abdominal hernia repair

Multifunctional Biomedical Adhesives

Correlating the mass and mechanical property changes during the degradation of PEG‐based adhesive

Contact Info

Product

Resources

About