Sutureless Pancreatojejunal Anastomosis Using an Absorbable Sealant: Evaluation in a Pig Model

Αrgyra, Eriphili; Polymeneas, G.; Karvouni, Evangelia; Kontorravdis, Nikolaos; Theodosopoulos, Theodosios; Arkadopoulos, Nikolaos

doi:10.1016/j.jss.2008.04.020

Cited by 9 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, there is a clinical report of the successful use of photopolymerized PEG adhesives for repairing ventricular wall rupture following mitral valve replacement [58]. In experimental models, the sealants have demonstrated efficacy for repairing acute aortic dissection [59], coronary artery anastomoses [60], inguinal hernia [61], pancreatic-jejunal anastomoses [62], and intestinal anastomoses [63], as well as for prevention of peritendinous adhesions following flexor tendon repair surgery [64]. However, despite desirable characteristics A second PEG-based sealant system is the PEG-PEG platform.…”

Section: Hydrogels For Wound Dressings and Wound Closurementioning

confidence: 99%

Hydrogel Materials

Holowka

Bhatia

2014

Drug Delivery

View full text Add to dashboard Cite

In Chap. 2, we discussed the fundamental behavior behind the release of drug molecules from matrix species in response to degradation (i.e., chemical or enzymatic), erosion (i.e., surface or bulk), and swelling (i.e., crosslinks). In the case of swellable systems, we limited our focus only to the adjustment of swelling characteristics based on changing the crosslink density, polymer molecular weight between crosslinks, and hydrophilicity. These underlying features provide information regarding the pharmacokinetics of the system; however, they provide little indication of the physical requirements for actual therapeutic applications. For example, what if a swellable system reached a point within the human body where the matrix could not sustain its own structural integrity? What would be the consequences of the system breaking apart? Could we see premature drug release [1], an inflammatory response [2], or perhaps worse, the occlusion of an artery [3]? When we use swellable systems in physiological environments, care must be taken to understand the properties, both chemical and physical, to which it will be exposed throughout its life cycle within the body.In this chapter, we will discuss aqueous swellable systems classified as hydrogels [4], and their applications as implantable [5] and injectable [6] systems. Hydrogels are a species of crosslinked, hydrophilic, polymer molecules that absorb large amounts of water (≤99 %) to form a three-dimensional network. There is a broad application base for hydrogel materials, ranging from tissue engineering scaffolds [7] to breast implants [8] to contact lenses [9] (discussed in Chap. 2, Sect. 2.3). For the purposes of our current discussion, we will focus on implantable biosensors for diabetes treatment [10] and injectable hydrogels for cartilage repair [11]. We begin

show abstract

Section: Hydrogels For Wound Dressings and Wound Closurementioning

confidence: 99%

Hydrogel Materials

Holowka

Bhatia

2014

Drug Delivery

View full text Add to dashboard Cite

show abstract

“…In gastrointestinal surgery, FGs are used for staple line sealing after gastric bypass in bariatric surgery . Furthermore, recent research reported promising results for the sealing of the esophageal and the pancreatico‐duodenal anastomosis with various TAs, including FG, CA, and PEG adhesives . Despite extensive experimental research in the field of colorectal surgery, anastomotic sealing with TAs has not yet been implemented into regular clinical practice.…”

Section: Introductionmentioning

confidence: 99%

“…20 Furthermore, recent research reported promising results for the sealing of the esophageal and the pancreatico-duodenal anastomosis with various TAs, including FG, CA, and PEG adhesives. [21][22][23][24][25][26] Despite extensive experimental research in the field of colorectal surgery, anastomotic sealing with TAs has not yet been implemented into regular clinical practice. As previously described in the literature, this may be (at least partially) attributed to a lack of methodological consensus between experimental studies, inhibiting the comparison of available experimental data.…”

Section: Introductionmentioning

confidence: 99%

Clinical, mechanical, and immunohistopathological effects of tissue adhesives on the colon: An in‐vivo study

Vakalopoulos

Kroese

et al. 2016

J Biomed Mater Res

View full text Add to dashboard Cite

Background: Tissue adhesives may be useful for sealing bowel anastomoses by preventing anastomotic leakage. Prior to clinical implementation, an in-depth analysis of the clinical and immunohistopathological effects of tissue adhesives on the target tissue and of the mechanical strength of the adhesive bond in an in vivo model is needed. Materials and methods:In 84 rats, two bowel segments were glued using one of the following tissue adhesive: Bioglue, Gelatin-resorcinol-formaldehyde (GRF), Glubran 2, Histoacryl Flex, Omnex, Duraseal Xact, or Tissucol. Rats were followed for 7 or 28 days. Endpoints were clinical complication rate, mechanical strength, and immunohistopathological reactions. Results: Of the seven tissue adhesives, GRF and Bioglue showed the highest rates of bowel wall destruction and ileus and the most severe immunohistopathological tissue reactions at 7 and 28 days. Cyanoacrylates (Histoacryl Flex, Omnex, Glubran 2) showed high mechanical strength and mild immunohistopathological reactions at 7 and 28 days. Duraseal Xact and Tissucol were the most inert tissue adhesives, but exhibited low mechanical strength. At 28 days, mechanical strength was significantly correlated to CD8, CD68, and Ki67 cell counts. Conclusion: Based on the clinical and immunohistopathological outcomes, GRF and Bioglue were found to be the least suitable tissue adhesives for colonic use. Duraseal Xact and Tissucol were inert but also showed low mechanical strength. Cyanoacrylates exhibited mild clinical and immunohistopathological effects while maintaining high strength, which makes them promising as colonic sealants.

show abstract

Traumatic Injuries

Bhatia

2010

Biomaterials for Clinical Applications

View full text Add to dashboard Cite

Sutureless Pancreatojejunal Anastomosis Using an Absorbable Sealant: Evaluation in a Pig Model

Cited by 9 publications

References 18 publications

Hydrogel Materials

Hydrogel Materials

Clinical, mechanical, and immunohistopathological effects of tissue adhesives on the colon: An in‐vivo study

Traumatic Injuries

Contact Info

Product

Resources

About