Sutureless Lamellar Corneoscleral Patch Graft With Fibrin Sealant for Limbal Dermoid Removal

Zhou, Andrew Xingyu; Ambati, Balamurali K.

doi:10.3928/01913913-20160509-03

Cited by 8 publications

(6 citation statements)

References 14 publications

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“…A fibrin-based adhesive was considered effective for sealing of conjunctival and skin grafts, LASIK flaps, and clear cornea incisions (Fig. 5Av) [118]. Likewise, the combined use of a fibrin glue and amniotic membrane transplantation was demonstrated as a safe and effective method for repairing corneas with perforations of around 2 mm [119].…”

Section: Fibrin and Fibrinogen-based Adhesivesmentioning

confidence: 99%

“…Adequate graft integration with no edema and minimum haze was observed. Adapted from Zhou et al[118] with permission from Healio, copyright 2016; (B) Albumin based adhesives: (i) The 3D structure of albumin; a globular protein abundantly present in animal serum, (ii) Mechanism of crosslinking and tissue adhesion of BioGlue ® , (iii) Schematic illustration of laser soldering using albumin-based solders. Adapted from Chao et al[126] with permission from Wiley, copyright 2003, (iv) Rat eyes glued with albumin soldering after corneal epithelium removal surgery, and (v) ex-vivo breaking strength measure on mouse skin soldered with albumin-based solder.…”

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confidence: 99%

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Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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Closure of ocular wounds after an accident or surgery is typically performed by suturing, which is associated with numerous potential complications, including suture breakage, inflammation, secondary neovascularization, erosion to the surface and secondary infection, and astigmatism; for example, more than half of post-corneal transplant infections are due to suture related complications. Tissue adhesives provide promising substitutes for sutures in ophthalmic surgery. Ocular adhesives are not only intended to address the shortcomings of sutures, but also designed to be easy to use, and can potentially minimize post-operative complications. Herein, recent progress in the design, synthesis, and application of ocular adhesives, along with their advantages, limitations, and potential are discussed. This review covers two main classes of ocular adhesives: (1) synthetic adhesives based on cyanoacrylates, polyethylene glycol (PEG), and other synthetic polymers, and (2) adhesives based on naturally derived polymers, such as proteins and polysaccharides. In addition, different technologies to cover and protect ocular wounds such as contact bandage lenses, contact lenses coupled with novel technologies, and decellularized corneas are discussed. Continued advances in this area can help improve both patient satisfaction and clinical outcomes.

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Section: Fibrin and Fibrinogen-based Adhesivesmentioning

confidence: 99%

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confidence: 99%

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

et al. 2019

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“…Excision alone can cause scarring, corneal vascularization, pseudopterygium, and symblepharon. 23 , 24 , 25 , 26 , 27 Closing the defect with partial-thickness corneal grafts after resection reduces the development of these complications and creates a more cosmetically pleasing appearance. 26 , 27 AMT and conjunctivo-Tenonplasty was performed in the same session as dermoid excision in patient 1 and approximately 15 months after dermoid excision performed in another center in an attempt to close the area of scleral melting in patient 2.…”

Section: Discussionmentioning

confidence: 99%

“…23 , 24 , 25 , 26 , 27 Closing the defect with partial-thickness corneal grafts after resection reduces the development of these complications and creates a more cosmetically pleasing appearance. 26 , 27 AMT and conjunctivo-Tenonplasty was performed in the same session as dermoid excision in patient 1 and approximately 15 months after dermoid excision performed in another center in an attempt to close the area of scleral melting in patient 2. When adequate results could not be obtained, the patients were referred to our center and underwent donor corneal grafting ( Figure 1b ).…”

Section: Discussionmentioning

confidence: 99%

Donor Cornea Use in Scleral Surface Reconstruction

Burcu¹,

Yalnız-Akkaya²,

Şingar³

et al. 2021

tjo

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Objectives: To investigate the indications for and results of treating scleral surface problems with donor corneal grafts that are not used in keratoplasty surgery or are left over from keratoplasty. Materials and Methods: The records of 16 patients in whom corneal tissue was used to repair a scleral tissue defect or cover an exposed glaucoma drainage implant were evaluated retrospectively. Partial-thickness grafts were prepared using a combined microkeratome system with artificial anterior chamber in 10 eyes and by manual dissection in 3 eyes. Full-thickness grafts were used in 3 eyes. Results: There were 8 female and 8 male patients aged 5-79 years (mean: 39.37±24.68). Indications for the use of corneal tissue on the scleral surface were limbal dermoid excision (n=2), pterygium surgery (n=1), intraocular lens removal and scleral fixation intraocular lens (SFIOL) implantation (n=1), exposed SFIOL suture coverage (n=1), trauma (n=2), scleral tissue loss due to repeated glaucoma surgeries (n=5), and exposed glaucoma drainage implant (n=4). The patients were followed for 6-42 months (mean: 14.37±9.14). None of the patients had graft infection, thinning, immunological graft rejection, or vision loss during follow-up. Tectonic lamellar grafts did not adversely affect final visual acuity in any case. At final examination, a good combination of graft and recipient tissue, a smooth ocular surface, and a cosmetic appearance were achieved in all eyes. Conclusion: Donor corneas that are not suitable for corneal transplantation or left over from the cornea transplant can be used in patients with scleral tissue loss due to various pathologies and in the treatment of glaucoma drainage implant erosion. In these cases, the use of corneal grafts provides a good ocular surface restoration and cosmetic appearance. The effectiveness and safety of this method should be investigated with large patient series and long follow-up times.

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“…The graft successfully healed and adhered, demonstrating the advantages of a sutureless method, which reduces scarring and the risk of infection. [ 101 ] Bladder leakage is a common complication in existing glaucoma filtration surgeries. The application of autologous fibrin tissue glue has shown success in repairing leaks, providing a non‐surgical treatment option.…”

Section: Natural Biomaterials For Corneal Tissue Engineeringmentioning

confidence: 99%

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

Prasathkumar

Chenthamara

Lin

et al. 2023

Adv Materials Technologies

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Corneal blindness is explained by a large reduction in vision loss caused by acute and chronic corneal diseases and/or disorders. Due to the severe unavailability of donor corneas, immune rejection, and the side effects of keratoprosthesis (KPro), vision‐impaired patients are often unable to restore their vision. Corneal tissue engineering appears to be a promising method using natural polymers made from different layers of corneal cells such as epithelium, stroma, and endothelium or full tissue equivalents. Proteins and polysaccharides are able to mimic the chemical composition of the native extracellular matrix (ECM), which has been extensively studied for corneal tissue engineering. Additionally, protein‐based materials are highly favored in corneal regenerative therapy as they have the proper cell‐binding sites for cell adhesion, corneal innervation regeneration, and oxidative stress suppression, while polysaccharide‐based materials can also promote cell proliferation and adhesion as well as ocular permeability. Herein, a comprehensive review of various biomaterials based on natural proteins (fibrin, fibrinogen, silk fibroin, collagen, gelatin, and serum albumin) and polysaccharides (chitin, chitosan, hyaluronic acid, alginate, cellulose, and gellan gum) for corneal tissue engineering are provided. The protein‐polysaccharide biomaterials are mainly used in the form of hydrogels, films, scaffolds, sutures, eye drops, nanocarriers, and nanocapsules to treat ocular diseases that cause blindness, such as corneal wounds, corneal ulcers, Goldenhar syndrome, corneal endothelium and stroma defects, corneal neovascularization, etc. In this review, insight is provided into recent developments in the areas of biomaterial design, cross‐linking strategy, corneal cell selection, and frontiers that are expected to offer researchers support and creativity in the development of corneal regenerative medicine.

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Sutureless Lamellar Corneoscleral Patch Graft With Fibrin Sealant for Limbal Dermoid Removal

Cited by 8 publications

References 14 publications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Ocular adhesives: Design, chemistry, crosslinking mechanisms, and applications

Donor Cornea Use in Scleral Surface Reconstruction

The Design and Developments of Protein‐Polysaccharide Biomaterials for Corneal Tissue Engineering

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