Suture augmentation following ACL injury to restore the function of the ACL, MCL, and medial meniscus in the goat stifle joint

Fisher, Matthew B.; Jung, Hosung; McMahon, Patrick J.; Woo, Savio L‐Y.

doi:10.1016/j.jbiomech.2011.02.141

Cited by 24 publications

(23 citation statements)

References 32 publications

(57 reference statements)

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“…The application of 200 N axial compressive force to passively flexed knees increased ATT. [36, 70] Axial compression also generated slightly greater ACL forces than did isolated valgus or isolated internal torque; however, these forces were lower than those produced by combined torsional loading. [32, 36, 69]…”

Section: Resultsmentioning

confidence: 99%

“…[55,58] This finding is in direct contrast with the passive flexion and weight-bearing flexion techniques that reported combined ATF and axial compressive loads increased ACL forces relative to either isolated loading condition. [14, 36, 70] The quadriceps forces that were applied in both impact testing devices and the weight-bearing flexion simulations were in excess of 1000 N; therefore, dissimilarities between methods did not arise from a disparity in muscle force magnitude. [14, 18, 21, 22, 33, 80, 81]…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Anterior cruciate ligament biomechanics during robotic and mechanical simulations of physiologic and clinical motion tasks: A systematic review and meta-analysis

Bates

Myer

Shearn

et al. 2015

Clinical Biomechanics

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Investigators use in vitro joint simulations to invasively study the biomechanical behaviors of the anterior cruciate ligament. The aims of these simulations are to replicate physiologic conditions, but multiple mechanisms can be used to drive in vitro motions, which may influence biomechanical outcomes. The objective of this review was to examine, summarize, and compare biomechanical evidence related to anterior cruciate ligament function from in vitro simulations of knee motion. A systematic review was conducted (2004 to 2013) in Scopus, PubMed/Medline, and SPORTDiscus to identify peer-reviewed studies that reported kinematic and kinetic outcomes from in vitro simulations of physiologic or clinical tasks at the knee. Inclusion criteria for relevant studies were articles published in English that reported on whole-ligament anterior cruciate ligament mechanics during the in vitro simulation of physiologic or clinical motions on cadaveric knees that were unaltered outside of the anterior-cruciate-ligament-intact, -deficient, and -reconstructed conditions. A meta-analysis was performed to synthesize biomechanical differences between the anterior-cruciate-ligament-intact and reconstructed conditions. 77 studies met our inclusion/exclusion criteria and were reviewed. Combined joint rotations have the greatest impact on anterior cruciate ligament loads, but the magnitude by which individual kinematic degrees of freedom contribute to ligament loading during in vitro simulations is technique-dependent. Biomechanical data collected in prospective, longitudinal studies corresponds better with robotic-manipulator simulations than mechanical-impact simulations. Robotic simulation indicated that the ability to restore intact anterior cruciate ligament mechanics with anterior cruciate ligament reconstructions was dependent on loading condition and degree of freedom examined.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Anterior cruciate ligament biomechanics during robotic and mechanical simulations of physiologic and clinical motion tasks: A systematic review and meta-analysis

Bates

Myer

Shearn

et al. 2015

Clinical Biomechanics

View full text Add to dashboard Cite

show abstract

“…[20][21][22][23] Furthermore, other studies stressed the importance of providing a suitable biological environment by adding a collagen matrix sponge [25][26][27][28][29] or PRP to stimulate healing. [30][31][32][33] The literature suggests a mutually inclusive relation between collagen matrix sponge and PRP.…”

Section: Discussionmentioning

confidence: 99%

“…Several authors investigated the role of stability during ACL repair. [20][21][22][23] Seitz et al 20 showed that stability obtained through an internal strut augmentation using a 3-mm polyethylene terephthalate (PET) band passed through femoral and tibial bone tunnels improved histologic evidence of healing when compared with the non-augmented repair construct. In their mountain sheep model, serial gross and histologic assessments were performed at varying time intervals up to 52 weeks.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Primary Repair of the Anterior Cruciate Ligament: A Systematic Review

Taylor

Khair

Roberts

et al. 2015

Arthroscopy: The Journal of Arthroscopic & Related Surgery

119

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“…However, these studies also found that the rate of healing was slow and mechanical augmentation would be required to maintain knee stability and facilitate the biological processes of ACL healing (Speziali et al, 2012). To this end, it was found that using sutures that directly connected the tibia and femur following ACL injury could restore knee stability and led to improvements in the healing of a transected ACL (Fisher et al, 2011; Fleming et al, 2008). …”

Section: Examples Of Mg-based Devices For Orthopaedic Applicationsmentioning

confidence: 99%

Revolutionizing orthopaedic biomaterials: The potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering

Farraro

Kim

Woo

et al. 2014

Journal of Biomechanics

Self Cite

184

100

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In recent years, there has been a surge of interest in magnesium (Mg) and its alloys as biomaterials for orthopaedic applications, as they possess desirable mechanical properties, good biocompatibility, and biodegradability. Also shown to be osteoinductive, Mg-based materials could be particularly advantageous in functional tissue engineering to improve healing and serve as scaffolds for delivery of drugs, cells, and cytokines. In this paper, we will present two examples of Mg-based orthopaedic devices: an interference screw to accelerate ACL graft healing and a ring to aid in the healing of an injured ACL. In vitro tests using a robotic/UFS testing system showed that both devices could restore function of the goat stifle joint. Under a 67-N anterior tibial load, both the ACL graft fixed with the Mg-based interference screw and the Mg-based ring-repaired ACL could restore anterior tibial translation (ATT) to within 2 mm and 5 mm, respectively, of the intact joint at 301, 601, and 901 of flexion. In-situ forces in the replacement graft and Mg-based ring-repaired ACL were also similar to those of the intact ACL. Further, early in vivo data using the Mg-based interference screw showed that after 12 weeks, it was non-toxic and the joint stability and graft function reached similar levels as published data. Following these positive results, we will move forward in incorporating bioactive molecules and ECM bioscaffolds to these Mg-based biomaterials to test their potential for functional tissue engineering of musculoskeletal and other tissues.

show abstract

Suture augmentation following ACL injury to restore the function of the ACL, MCL, and medial meniscus in the goat stifle joint

Cited by 24 publications

References 32 publications

Anterior cruciate ligament biomechanics during robotic and mechanical simulations of physiologic and clinical motion tasks: A systematic review and meta-analysis

Anterior cruciate ligament biomechanics during robotic and mechanical simulations of physiologic and clinical motion tasks: A systematic review and meta-analysis

Primary Repair of the Anterior Cruciate Ligament: A Systematic Review

Revolutionizing orthopaedic biomaterials: The potential of biodegradable and bioresorbable magnesium-based materials for functional tissue engineering

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