Sutterella faecalis sp. nov., isolated from human faeces

Oh, Byeong Seob; Kim, Ji Sun; Yu, Seung Yeob; Ryu, Seoung Woo; Park, Seung-Hwan; Kang, Se Won; Park, Jam Eon; Choi, Seung Hyeon; Han, Kook Il; Lee, Keun Chul; Eom, Mi Kyung; Suh, Min Kuk; Kim, Han Sol; Lee, Dong Hoon; Yoon, Hyuk; Kim, Byung Yong; Lee, Jehee; Lee, Jung Sook

doi:10.1007/s12275-020-9396-9

Cited by 6 publications

(3 citation statements)

References 24 publications

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“…An increase in the abundance of Sutterella , Synergistes , Anaerostipes , Ruminiclostridium , and Rikenellaceae in the gut caused by long-term addition of FVW was also observed in this study. Sutterella is an obligately anaerobic, Gram-negative bacterium ( 49 ), and there is a negative correlation between the presence or abundance of Sutterella and the host inflammatory cytokine response ( 50 , 51 ). Synergistes is related to reduce gastrointestinal inflammation and enhances immune function ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

et al. 2023

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Section: Discussionmentioning

confidence: 99%

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

et al. 2023

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“…Sutterella species have been isolated from human fecal samples [ 35 , 36 , 37 , 38 , 39 , 40 , 41 ] and implicated in various human health conditions, including ulcerative colitis [ 42 ], autism spectrum disorders (ASD) [ 43 , 44 ], bacteremia [ 45 ], multiple sclerosis [ 46 ], and autoimmune based thyroid disease [ 47 ]. Additionally, Sutterella is known to degrade immunoglobulin A (IgA), suggesting a pro-inflammatory role [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic Analysis of Sulfotransferases from an Unexplored Gut Microbe, Sutterella wadsworthensis 3_1_45B: Possible Roles towards Detoxification via Sulfonation by Members of the Human Gut Microbiome

Langford,

Shah

2024

IJMS

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Sulfonation, primarily facilitated by sulfotransferases, plays a crucial role in the detoxification pathways of endogenous substances and xenobiotics, promoting metabolism and elimination. Traditionally, this bioconversion has been attributed to a family of human cytosolic sulfotransferases (hSULTs) known for their high sequence similarity and dependence on 3′-phosphoadenosine 5′-phosphosulfate (PAPS) as a sulfo donor. However, recent studies have revealed the presence of PAPS-dependent sulfotransferases within gut commensals, indicating that the gut microbiome may harbor a diverse array of sulfotransferase enzymes and contribute to detoxification processes via sulfation. In this study, we investigated the prevalence of sulfotransferases in members of the human gut microbiome. Interestingly, we stumbled upon PAPS-independent sulfotransferases, known as aryl-sulfate sulfotransferases (ASSTs). Our bioinformatics analyses revealed that members of the gut microbial genus Sutterella harbor multiple asst genes, possibly encoding multiple ASST enzymes within its members. Fluctuations in the microbes of the genus Sutterella have been associated with various health conditions. For this reason, we characterized 17 different ASSTs from Sutterella wadsworthensis 3_1_45B. Our findings reveal that SwASSTs share similarities with E. coli ASST but also exhibit significant structural variations and sequence diversity. These differences might drive potential functional diversification and likely reflect an evolutionary divergence from their PAPS-dependent counterparts.

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“…Interestingly, we discovered that Sutterella, a genus within the human gut microbiome, contains multiple genes annotated for these sulfotransferases. Sutterella species have been isolated from human fecal samples (35)(36)(37)(38)(39)(40)(41) and implicated in various human health conditions, including ulcerative colitis (42), autism spectrum disorders (ASD) (43,44), bacteremia (45), multiple sclerosis (46), and autoimmune based thyroid disease (47). Additionally, Sutterella is known to degrade immunoglobulin A (IgA), suggesting a pro-inflammatory role (48).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic analysis of sulfotransferases from an unexplored gut microbe,Sutterella wadsworthensis 3_1_45B: Possible roles towards detoxification via sulfation by the members of the human gut microbiome

Langford,

Shah

2024

Preprint

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Sulfation, primarily facilitated by sulfotransferases, plays a crucial role in the detoxification pathways of both endogenous substances and xenobiotics, enhancing their water solubility and promoting metabolism and elimination. Traditionally, this bioconversion has been attributed to a family of human cytosolic sulfotransferases (hSULTs) known for their high sequence similarity and dependence on 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a sulfate donor. However, recent studies have revealed the presence of PAPS-dependent sulfotransferases within gut commensals, indicating that the gut microbiome may harbor a diverse array of sulfotransferase enzymes and may contribute to detoxification processes via sulfation. In this study, we investigated the prevalence of sulfotransferases in the members of the human gut microbiome. Interestingly, we stumbled upon a different class of sulfotransferases, known as aryl-sulfate sulfotransferases (ASSTs). ASSTs have been characterized from a few different prokaryotes includingE. coli. ASSTs do not utilize PAPS which is the default sulfate donor for the human sulfotransferases. Our bioinformatics analyses revealed that the gut microbial genusSutterellapossesses a significant number ofasstgenes, possibly encoding multiple ASST enzymes. Fluctuations in the microbes of the genusSutterellahave been associated with various health conditions. For this reason, we characterized 17 different ASSTs fromSutterella wadsworthensis 3_1_45Bwith bioinformatics. Our findings reveal thatSwASSTs share similarities withE. coliASST but also exhibit significant structural variations and sequence diversity. These differences might drive potential functional diversification and likely reflect an evolutionary divergence from their PAPS-dependent counterparts.

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Sutterella faecalis sp. nov., isolated from human faeces

Cited by 6 publications

References 24 publications

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

Longitudinal Study of the Effects of Flammulina velutipes Stipe Wastes on the Cecal Microbiota of Laying Hens

Bioinformatic Analysis of Sulfotransferases from an Unexplored Gut Microbe, Sutterella wadsworthensis 3_1_45B: Possible Roles towards Detoxification via Sulfonation by Members of the Human Gut Microbiome

Bioinformatic analysis of sulfotransferases from an unexplored gut microbe,Sutterella wadsworthensis 3_1_45B: Possible roles towards detoxification via sulfation by the members of the human gut microbiome

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