Sustentacular cells in pulmonary neuroendocrine tumours

Gosney,; Denley,; Rešl,

doi:10.1046/j.1365-2559.1999.00595.x

Cited by 27 publications

(19 citation statements)

References 17 publications

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“…In addition, focal keratin expression is occasionally seen in both sympathetic and head and neck paragangliomas (Johnson et al 1988, Chetty et al 1998, Labrousse et al 1999. Immunostaining of sustentacular cells for S100 can be helpful in diagnosing paragangliomas but is not specific because these enigmatic cells can also be present in other neuroendocrine tumors (Gosney et al 1999). …”

Section: Differential Diagnosismentioning

confidence: 99%

15 YEARS OF PARAGANGLIOMA: Pathology of pheochromocytoma and paraganglioma

Tischler¹,

deKrijger²

2015

Endocrine-Related Cancer

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Pathologists using their routine diagnostic tools can contribute both to the care of patients with pheochromocytoma/paraganglioma and to understanding the pathobiology of the tumors. They can document details of tissue organization and cytology that are accessible only by microscopy and can characterize admixtures of cell types that are morphologically distinct or show differential expression of immunohistochemical markers. Current roles and challenges for pathologists include differential diagnosis, identifying clues to the presence of hereditary disease, and effective communication of pathology information for clinical and research purposes. Future roles will increasingly involve risk stratification, identification of actionable targets for personalized therapies, and aiding the interpretation of molecular tests by helping characterize genetic variants of unknown significance. It remains to be determined to what extent the need for pathology input will be overshadowed by the availability of genetic testing and other molecular analyses at ever-decreasing cost, together with very effective clinical paradigms for risk stratification and patient care.

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Section: Differential Diagnosismentioning

confidence: 99%

15 YEARS OF PARAGANGLIOMA: Pathology of pheochromocytoma and paraganglioma

Tischler¹,

deKrijger²

2015

Endocrine-Related Cancer

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“…) . Demonstration of S100‐positive sustentacular network also favors a diagnosis of paraganglioma in surgical specimens; however, S100‐positive sustentacular cells can be identified in other NETs, including pituitary adenomas, gastroenteropancreatic and pulmonary NETs . Therefore, the identification of sustentacular cells is not helpful in this distinction.…”

Section: Introductionmentioning

confidence: 99%

Algorithmic approach to neuroendocrine tumors in targeted biopsies: Practical applications of immunohistochemical markers

Duan

Mete

2016

Cancer Cytopathology

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Neuroendocrine tumors (NETs) constitute a heterogeneous group of neoplasms with distinct biological behaviors, depending on the site of origin and the degree of tumor proliferation. Although advances in biochemical and radiological modalities have enhanced the ability to detect NETs, tissue diagnosis remains the gold standard to assess tumor characteristics for treatment decision making. In an era with growing demands for precision diagnostics based on smaller tissue samples, immunohistochemistry has become an indispensable tool in the pathologist's repertoire. In conjunction with clinical findings and cytomorphology, complementary use of 1) markers of neuroendocrine differentiation, 2) markers confirming epithelial nature, 3) markers of cellular proliferation, 4) transcription factors and hormonal markers, as well as 5) predictive and prognostic markers may be necessary to guide patient management in NETs. The current review summarizes common applications of these immunohistochemical markers when confronted with a potential neuroendocrine neoplasm, and proposes a stepwise algorithmic approach to avoid diagnostic errors in targeted biopsies. Cancer Cytopathol 2016;124:871-84. V C 2016 American Cancer Society.

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“…Another source of possible confusion is tumor invasion of adjacent nerves and incorporation of Schwann cells in the in ltrating tumor cell nests. Indiscriminate acceptance of all S -100 protein -positive dendritic cells as sustantacula r cells would increase the apparent rate of sustantacular cells reported in bronchial carcinoids [ 22,51 ]. Such might be the case of ordinary bronchial carcinoid s containing sporadic S -100 positive cells.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, pulmonary carcinoids are similar to their counterparts of the gastrointestinal tract in histogenesis and histomorphologic presentations. The putative progenitor cells are cuboidal to columnar gland -lining epithelial cells [ 22 ]. The tumor cells in typical carcinoid assume ployhedral epithelial shape, and their tumors are typically arranged in an insular pattern with anastomosing cords and trabeculae of epithelial cells.…”

Section: Discussionmentioning

confidence: 99%