Sustained Virologic Response Decreases Serum Markers of Angiogenesis, Inflammation, and Fibrosis in HIV/HCV-Coinfected Patients on Hepatitis C Virus Therapy

The effect of curing hepatitis C with direct-acting antiviral treatment on endothelial function

“…To our knowledge, this is the first published study assessing the response of endothelial function to directacting antiviral treatment in non-cirrhotic patients with HCV monoinfection. Previous studies have shown an association between HIV-HCV coinfection and endothelial dysfunction [14,15], and have also shown a trend to improvement of endothelial function in such patients treated with interferon-based therapy [29,30]. Furthermore, endothelial function has been shown to be impaired in people with cirrhosis [31,32], but it is unclear if this is due to changes associated with cirrhosis per se, or due to HCV.…”