Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer

Abstract

Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA-PEG-PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC). The copolymer was synthesized by ring-opening polymerization reaction, using microwave irradiation and characterized by different techniques. It was shown that the introduction of NaDC to the PLGA-PEG-PLGA copolymer did not influence its inherent sol-gel transition behaviour, but increased the sol-gel transition. The results showed the appropriate NaDC/polymer interaction and the formation of NaDC/polymer-mixed micelle. The sustained release of NaDC from the copolymer lasted for 2 days. This release can be attributed to the formation of NaDC/polymer-mixed micelles and trapping NaDC in the copolymer matrix. The cytolytic efficacy of NaDC-loaded copolymer and sustained release of NaDC were investigated on human adipocytes. Overall a sustained-release formulation for NaDC can be used to study localized fat dissolution.

Localised delivery of quercetin by thermo-sensitive PLGA-PEG-PLGA hydrogels for the treatment of brachial plexus avulsion

“…However, due to the irregular shape of BPA, it is difficult to make the nerve conduit or stent match the morphology of the damage and to implant it into the ideal position. Injectable biodegradable hydrogels have attracted much attention because of their good biocompatibility, safety, injectability, fluidity, gel-forming property and convenience of operation [12][13][14], and the hydrogel can quickly complete its sol to gel transition based on temperature changes. It is a solution at room temperature, and rapidly converts into a gel at 37 C, even in a dose-and time-dependent manner [15,16].…”

Metal-organic framework IRMOFs coated with a temperature-sensitive gel delivering norcantharidin to treat liver cancer

“…In recent years, with the wide application of medical polymer materials and increased clinical utilization[ 27 , 28 ], research on sustained-release and controlled-release preparations has increased and has become an important research direction. As a new type of drug formulation, sustained- and controlled-release preparations can increase efficacies and reduce side effects compared with traditional drugs.…”

Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides

“…(Wang et al, 2017;Liang et al, 2020;Schiapparelli et al, 2020). The drug-peptide conjugates firstly served as prodrugs and would then fabricate into supramolecular nanomedicines by site-selective stimulus, including factors in microenvironment such as different ionic strengths or pH (Cong et al, 2019;Kubota et al, 2020) and temperatures, (Nasrollahi et al, 2018;Ji et al, 2019), upregulated redox molecules namely glutathione, (Xu et al, 2018), hydrogen peroxide and some other reactive oxygen species, (Miao et al, 2013;Wu et al, 2019), and abnormally expressed enzymes like esterases, proteases and phosphatases, (Li et al, 2015;Shi et al, 2018;Wang H et al, 2019), such in-situ SA approach gained success in enhancing the permeability of nanomedicine and increasing the concentration of therapeutic agents at disease sites. (Cai et al, 2017;Cheng et al, 2019a;Feng et al, 2019;Zhou et al, 2019).…”