Sustained release of naringin from silk-fibroin-nanohydroxyapatite scaffold for the enhancement of bone regeneration

Anisotropic silk nanofiber layers as regulators of angiogenesis for optimized bone regeneration

“…Angiogenesis and osteogenesis are major determinants of successful bone repair and these processes have been regulated by introducing multiple physical/chemical cues to bone biomaterials to study the impact in vivo [ [4] , [5] , [6] , [7] ]. Although faster and better bone regeneration has been achieved based on these bioactive biomaterial matrices, challenges remain to tune angiogenesis and osteogenesis outcomes in a dynamic way to simulate the different stages of the natural bone regeneration process [ 8 ].…”

The Contribution of Silk Fibroin in Biomedical Engineering

“…For this purpose, in a recent study, Zhao et al (2022) [ 166 ] developed SF-based scaffolds. One of the key players when it comes to bone repair and healing processes is hydroxyapatite.…”

“…Second, they used rabbits as a model organism to evaluate the bone repair process; more specifically, they surgically induced significant lesions of distal femoral epiphysis. The results indicated that the obtained biomaterial has great potential in the bone regeneration area by promoting bone defect healing [ 166 ].…”

Bioinspired silk fibroin materials: From silk building blocks extraction and reconstruction to advanced biomedical applications

“…In this review, we are more focused on its unique application in the fields of cell-material interactions, soft tissue engineering, and flexible bioelectronic devices. As for the other important biomedical applications, such as wound dressing, hard tissue engineering and drug delivery etc ., extensive descriptions could be seen from previous publications [ 28 , 29 , [109] , [110] , [111] , [112] , [113] , [114] , [115] , [116] , [117] ].…”