Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease

Zhang, Lei; Zhao, Penghe; Yue, Caiping; Jin, Zhaokui; Liu, Qiong; Du, Xiubo; He, Qianjun

doi:10.1016/j.biomaterials.2019.01.037

Cited by 117 publications

(58 citation statements)

References 70 publications

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“…Recently, an interesting work proposed the use of Pd hydride (PdH) nanoparticles as a possible treatment of Alzheimer's disease. The results obtained by Zhang et al were quite remarkable, showing that PdH were able to scavenge • OH, suppress Aβ over‐production, reverse synaptic deficit, ameliorate mitochondrial dysfunction, and even reduce cognitive impairments in Alzheimer's disease mice models . The authors theorized that the obtained results were due not only to PdH nanoparticles' antioxidant ability, yet also to their capacity to generate hydrogen molecule (H 2 ) as a by‐product of • OH scavenging.…”

Section: Inorganic Nano‐antioxidants For Biomedical Applicationsmentioning

confidence: 99%

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

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Many central nervous system (CNS) diseases are still incurable and only symptomatic treatments are available. Oxidative stress is suggested to be a common hallmark, being able to cause and exacerbate the neuronal cell dysfunctions at the basis of these pathologies, such as mitochondrial impairments, accumulation of misfolded proteins, cell membrane damages, and apoptosis induction. Several antioxidant compounds are tested as potential countermeasures for CNS disorders, but their efficacy is often hindered by the loss of antioxidant properties due to enzymatic degradation, low bioavailability, poor water solubility, and insufficient blood–brain barrier crossing efficiency. To overcome the limitations of antioxidant molecules, exploitation of nanostructures, either for their delivery or with inherent antioxidant properties, is proposed. In this review, after a brief discussion concerning the role of the blood–brain barrier in the CNS and the involvement of oxidative stress in some neurodegenerative diseases, the most interesting research concerning the use of nano‐antioxidants is introduced and discussed, focusing on the synthesis procedures, functionalization strategies, in vitro and in vivo tests, and on recent clinical trials.

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Section: Inorganic Nano‐antioxidants For Biomedical Applicationsmentioning

confidence: 99%

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Martinelli

Pucci

Battaglini

et al. 2019

Adv Healthcare Materials

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“…Abundant hydrogen can be loaded and stabilized within the lattice of Pd crystals to form Pd hydride. [ 23 ] In light of this, the PCN‐224@Pd nanoparticles suspension was bubbled with fresh H 2 , which was produced through blending dilute sulphuric acid (H 2 SO 4 ) solution with sodium borohydride (NaBH 4 ) powder (Figure S8, Supporting Information), with the result that the color was slightly darkened and the PCN‐224@Pd/H 2 nanosystems were obtained. Methylene blue (MB) has been generally used to combine with Pt nanoparticles for catalyzing hydrogenation reaction and quickly detecting hydrogen.…”

Section: Resultsmentioning

confidence: 99%

Palladium Nanocrystals‐Engineered Metal–Organic Frameworks for Enhanced Tumor Inhibition by Synergistic Hydrogen/Photodynamic Therapy

Chen

Lin

Zhao

et al. 2020

Adv Funct Materials

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Hydrogen therapy, as a star therapeutic modality, has recently acquired much attention in the field of anticancer medicine. Evidence suggests that hydrogen can selectively reduce intratumoral overexpressed hydroxyl radicals (•OH) to break the redox homoeostasis and thereby result in redox stress and cell damage. As a reactive oxygen species‐related noninvasive modality, photodynamic therapy (PDT) has been approved for varied tumor treatments clinically. For implementing tumor therapy with enhanced anticancer efficacy and attenuated side effects, here a biocompatible palladium nanocrystals‐integrated nanoscale porphyrinic metal–organic framework (NPMOF) is designed to develop a novel combined therapy modality, that is, synergistic hydrogen/photodynamic therapy. The NPMOF is employed simultaneously as the photosensitizer for PDT and as the nanocarrier to support palladium nanocrystals, which is further used as the hydrogen vehicle. The final hydrogen‐containing nanosystems exhibit a persistent reductive hydrogen release behavior and considerable light‐activated singlet oxygen (1O2) generation without mutual interference, contributing to the adequate disturbance of tumor microenvironment redox steady‐state for synergistically inducing tumor cell death. Ultimately, by coupling of tumor‐selective hydrogen therapy and PDT, the designed nanosystems realize the augmented therapeutic outcome with minimal side effects, providing a safe and efficient tumor treatment for future clinical translation.

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“… 33 In a dementia mice model (transgenic mice (DAL101) lacking aldehyde dehydrogenase 2), drinking hydrogen-water could reduce oxidative stress, suppress the decline in learning and memory impairment, decrease neurodegeneration and extend the mean of lifespan of mice. 34 Recently, Zhang et al 35 developed a small-sized palladium hydride nanoparticle that could release hydrogen sustainably in Alzheimer’s disease brain, and they demonstrated that it could overcome the cognitive impairment in Alzheimer’s disease mice via recovering mitochondrial dysfunction, inhibiting β-amyloid generation and aggregation, reducing oxidative stress and activating the anti-oxidative pathway. Additionally, drinking hydrogen water could alleviate cognitive impairment and inhibit hippocampal neurodegeneration in a mouse model of Parkinson’s disease.…”

Section: A Pplication Of H Ydrogen On C Entral N Ervous S mentioning

confidence: 99%

Role of hydrogen in traumatic brain injury: a narrative review

Chen

Liu

et al. 2021

Med Gas Res

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Traumatic brain injury (TBI) is a serious global public health problem. Survivors of TBI often suffer from long-term disability, which puts a heavy burden on society and families. Unfortunately, up to now, there is no efficacious treatment for TBI patients in clinical practice. As a reducing gas, hydrogen has been shown to be neuroprotective in multiple cerebral disease models; however, its efficacy in TBI remains controversial. In this review, we will focus on the results of hydrogen in experimental TBI, elaborate the potential mechanisms, and put forward for future researches based on our current understanding and views.

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Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease

Cited by 117 publications

References 70 publications

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Antioxidants and Nanotechnology: Promises and Limits of Potentially Disruptive Approaches in the Treatment of Central Nervous System Diseases

Palladium Nanocrystals‐Engineered Metal–Organic Frameworks for Enhanced Tumor Inhibition by Synergistic Hydrogen/Photodynamic Therapy

Role of hydrogen in traumatic brain injury: a narrative review

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