Sustained release hGH microsphere formulation produced by a novel supercritical fluid technology: In vivo studies

Jordan, Faron; Naylor, Andrew; Kelly, Catherine A.; Howdle, Steven M.; Lewis, Andrew L.; Illum, Lisbeth

doi:10.1016/j.jconrel.2009.09.013

Cited by 77 publications

(51 citation statements)

References 22 publications

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“…As reported for other sustained-release systems, [37,38] the drug absorption appeared to be delayed for the AEAcoated nanohybrid because the drug that was entrapped within the MMT interlayer would be released slowly during its passage through the intestine. The apparent volume of distribution (V d /F) and elimination half-life (t 1/2 ) values were not significantly different between two samples (Table 2).…”

Section: Pharmacokinetics Of Apz and Dehydro-apzsupporting

confidence: 56%

AripiprazoleMontmorillonite: A New Organic–Inorganic Nanohybrid Material for Biomedical Applications

Choi

Choy

et al. 2013

Chemistry A European J

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Poor aqueous solubility and the unpleasant taste of aripiprazole (APZ) have been recurring problems, owing to its low bioavailability and low patient tolerance, respectively. Herein, we prepared a nanohybrid system that was based on a bentonite clay material, montmorillonite (MMT), which could both mask the taste and enhance the solubility of APZ (i.e., APZ-MMT). To further improve the efficacy of this taste masking and drug solubility, APZ-MMT was also coated with a cationic polymer, polyvinylacetal diethylamino acetate (AEA). In vitro dissolution tests at neutral pH showed that the amount of drug that was released from the AEA-coated APZ-MMT was greatly suppressed (<1%) for the first 3 min, thus suggesting that AEA-coated APZ-MMT has strong potential for the taste masking of APZ. Notably, in simulated gastric juice at pH 1.2, the total percentage of APZ that was released within the first 2 h increased up to 95% for AEA-coated APZ-MMT. Furthermore, this in vitro release profile was also similar to that of Abilify®, a commercially available medication. In vivo experiments by using Sprague-Dawley rats were also performed to compare the pharmacokinetics of AEA-coated APZ-MMT and Abilify®. AEA-coated APZ-MMT exhibited about 20% higher systemic exposure of APZ and its metabolite, dehydro-APZ, compared with Abilify®. Therefore, a new MMT-based nanovehicle, which is coated with a cationic polymer, can act as a promising delivery system for both taste masking and for enhancing the bioavailability of APZ.

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Section: Pharmacokinetics Of Apz and Dehydro-apzsupporting

confidence: 56%

AripiprazoleMontmorillonite: A New Organic–Inorganic Nanohybrid Material for Biomedical Applications

Choi

Choy

et al. 2013

Chemistry A European J

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“…Direct comparison of the results achieved in the present work to data reported in the literature has to be performed with caution, given that the overall characteristics and performance of the particulate systems are very dependent on the incorporation method, on the polymeric systems and on the type of active agent incorporated. The results of a few works related to the study described herein also focusing the trapping of hormones in particles obtained using supercritical-based technologies show that incorporation efficiencies may vary from 65% for insulin in PEG/PLA particles [49] to 100% for human growth hormone in PLGA/PLA particles [50]. These peptide hormones are not soluble in the supercritical fluid and the encapsulation efficiency below 100% for insulin is related to its solubility in the remaining organic solvent during particle processing.…”

Section: Incorporation Of Mt In Pla/pcl Particles and Its Effects On mentioning

confidence: 96%

Properties of PLA/PCL particles as vehicles for oral delivery of the androgen hormone 17α-methyltestosterone

Sacchetin

Setti

Rosa

et al. 2016

Materials Science and Engineering: C

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“…Therefore, the development of halogenated solvent-free encapsulation methods is of great interest. From this point of view, protein encapsulation into PLGA particles using supercritical or compressed CO 2 -based processes emerges as a promising technology to completely eliminate these solvents or at least to minimize their use (Jordan et al, 2010;Tran et al, 2014;Tran et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

Swed

Cordonnier

Dénarnaud

et al. 2015

International Journal of Pharmaceutics

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Sustained release hGH microsphere formulation produced by a novel supercritical fluid technology: In vivo studies

Cited by 77 publications

References 22 publications

AripiprazoleMontmorillonite: A New Organic–Inorganic Nanohybrid Material for Biomedical Applications

AripiprazoleMontmorillonite: A New Organic–Inorganic Nanohybrid Material for Biomedical Applications

Properties of PLA/PCL particles as vehicles for oral delivery of the androgen hormone 17α-methyltestosterone

Sustained release of TGF-β1 from biodegradable microparticles prepared by a new green process in CO2 medium

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