Sustained-release Bupropion Versus Naltrexone in the Treatment of Pathological Gambling

Abstract

This preliminary study shows that sustained-release bupropion may be effective as naltrexone in the treatment of PG. Further studies are needed to confirm our findings.

Sustain Released Bupropion in the Treatment of Tricotillomania: Outpatient Follow Up Survey

“…Several preliminary studies suggest that bupropion SR may have a role in the treatment of PG [33,34]. Bupropion SR selectively inhibits the reuptake of DA and NA, which in turn stimulate acetylcholine, hydroxytryptamine, and GABA receptors as well as endorphins [30].…”

Differential effects of bupropion on acquisition and performance of an active avoidance task in male mice

“…In addition, bupropion is a candidate for treatment of psychostimulant drug abuse (Castells et al, 2010;Schindler et al, 2011), cannabis addiction (Penetar et al, 2012), pathological gambling (Dannon et al, 2005), or excessive online game playing (Han and Renshaw, 2012). The treatment with naltrexone plus bupropion may also be useful for overweight and obesity (Greenway et al, 2010;Yanovski and Yanovski, 2015).…”

Pathological Gambling

“…Our group reported the effectiveness of bupropion in a randomized drug comparison study (bupropion vs. naltrexone) and in a group of treatment-resistant pathological gamblers. 25 …”

“…20,21 Over the past 7 years, we have conducted a number of clinical research protocols in our cohort of Israeli pathological gamblers. Our protocols included case-controlled family studies, 22,23 blind-rater medication studies, [24][25][26] neurocognitive studies (reference 27 and S. Kertzman, M.D. ; K.L.…”