Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regeneration

Zhang, Yuanhao; Chen, Mingjiao; Dai, Zhaobo; Cao, Hongliang; Li, Jin

doi:10.1039/c9bm01455a

Cited by 33 publications

(31 citation statements)

References 54 publications

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“…Bone transplantation is the main method for the treatment of bone damage but it is becoming more and more difficult to obtain a donor while the easier allogeneic transplantation often leads to an immune rejection and a big spending. [155,156] Filling the defected bones with the hydrogels carrying functional cells and inducing the new bone growth in situ has become a recent good strategy to address www.advancedsciencenews.com www.mrc-journal.de these appeals. There were several self-healing polysaccharide hydrogels applied to repair the damaged structure and function of the bones, [157,158] and the coral hydroxyapatite (CHA), which has a structure similar to cancellous bone tissue and is often used as a bone graft substitute, has been chosen for the fabrication of such a scaffolding hydrogel material.…”

Section: Cell Therapymentioning

confidence: 99%

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Chen

2021

Macromol. Rapid Commun.

126

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Injectable hydrogel possesses great application potential in disease treatment and tissue engineering, but damage to gel often occurs due to the squeezing pressure from injection devices and the mechanical forces from limb movement, and leads to the rapid degradation of gel matrix and the leakage of the load material. The self-healing injectable hydrogels can overcome these drawbacks via automatically repairing gel structural defects and restoring gel function. The polysaccharide hydrogels constructed through the Schiff base reaction own advantages including simple fabrication, injectability, and self-healing under physiological conditions, and therefore have drawn extensive attention and investigation recently. In this short review, the preparation and self-healing properties of the polysaccharide hydrogels that is established on the Schiff base reaction are focused on and their biological applications in drug delivery and cell therapy are discussed.

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Section: Cell Therapymentioning

confidence: 99%

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Chen

2021

Macromol. Rapid Commun.

126

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“…reported that hyaluronic acid–Dextran–Laponite RD (HD‐LAP) hydrogels embedded with rat bone marrow mesenchymal stem cells (rBMSC) and BMP‐2 were able to promote new tissue generation after 8 weeks postimplantation in contrast to control groups. [ 69 ] Similarly, a Laponite RD‐alginate‐methylcellulose bioink was fabricated by Cidonio et al., and its biocompatibility and osteogenic capacity were subjected to in vitro and in vivo tests. [ 70 ] Once its effectiveness in vitro and ex vivo was demonstrated, in vivo subcutaneous implantation of BMP‐2 loaded and human bone marrow stromal cells (HBMSC) laden ones were conducted.…”

Section: In Vivo Studiesmentioning

confidence: 99%

“…On the one hand, there are studies that conclude that nanoclays are capable of regenerating bone thanks to the inducing medium they create via mineral dissolution products, [ 61,67,73,77,84 ] while other studies have focused more on the ability of nanomaterials to sustain the release of drugs or growth factors. [ 49,69,71,86 ]…”

Section: In Vivo Studiesmentioning

confidence: 99%

Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders

Erezuma

Eufrásio-da-Silva

Golafshan

et al. 2021

Adv Healthcare Materials

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Nanoclay‐reinforced biomaterials have sparked a new avenue in advanced healthcare materials that can potentially revolutionize treatment of musculoskeletal defects. Native tissues display many important chemical, mechanical, biological, and physical properties that engineered biomaterials need to mimic for optimal tissue integration and regeneration. However, it is time‐consuming and difficult to endow such combinatorial properties on materials via feasible and nontoxic procedures. Fortunately, a number of nanomaterials such as graphene, carbon nanotubes, MXenes, and nanoclays already display a plethora of material properties that can be transferred to biomaterials through a simple incorporation procedure. In this direction, the members of the nanoclay family are easy to functionalize chemically, they can significantly reinforce the mechanical performance of biomaterials, and can provide bioactive properties by ionic dissolution products to upregulate cartilage and bone tissue formation. For this reason, nanoclays can become a key component for future orthopedic biomaterials. In this review, we specifically focus on the rapidly decreasing gap between clinic and laboratory by highlighting their application in a number of promising in vivo studies.

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“…Another example of self-healing hydrogel nanocomposite for bone tissue regeneration based on hyaluronic acid and dextran has been reported [ 120 ]. This hydrogel could be in situ formed through a spontaneous Schiff-base reaction.…”

Section: Tissue Engineering Applicationsmentioning

confidence: 99%

“… ( A ) In vivo study of the evaluation of calvarial bone defect regeneration at 4 and 8 weeks after the implantation and ( B ) analysis of bone volume/total volume (BV/TV) and bone mineral density (BMD) (* p < 0.05, ** p < 0.01 and *** p < 0.001). Reproduced with permission from [ 120 ] (Copyright RSC 2020). …”

Section: Figurementioning

confidence: 99%

Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

et al. 2020

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In situ hydrogels have attracted increasing interest in recent years due to the need to develop effective and practical implantable platforms. Traditional hydrogels require surgical interventions to be implanted and are far from providing personalized medicine applications. However, in situ hydrogels offer a wide variety of advantages, such as a non-invasive nature due to their localized action or the ability to perfectly adapt to the place to be replaced regardless the size, shape or irregularities. In recent years, research has particularly focused on in situ hydrogels based on natural polysaccharides due to their promising properties such as biocompatibility, biodegradability and their ability to self-repair. This last property inspired in nature gives them the possibility of maintaining their integrity even after damage, owing to specific physical interactions or dynamic covalent bonds that provide reversible linkages. In this review, the different self-healing mechanisms, as well as the latest research on in situ self-healing hydrogels, is presented, together with the potential applications of these materials in tissue regeneration.

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Sustained protein therapeutics enabled by self-healing nanocomposite hydrogels for non-invasive bone regeneration

Abstract: The self-healing nanocomposite hydrogel for sustained release of BMP-2 to enhance bone regeneration.

Cited by 33 publications

References 54 publications

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Advances in Injectable and Self‐healing Polysaccharide Hydrogel Based on the Schiff Base Reaction

Nanoclay Reinforced Biomaterials for Mending Musculoskeletal Tissue Disorders

Polysaccharide-Based In Situ Self-Healing Hydrogels for Tissue Engineering Applications

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