Sustained participation, colonoscopy uptake and adenoma detection rates over two rounds of the Tallaght–Trinity College colorectal cancer screening programme with the faecal immunological test

McNamara, Deirdre; Leen, Ronan; Seng-Lee, Chun; Shearer, Nikki; Crotty, Paul; Neary, Paul; Walsh, Paul; Boran, Gerard; O’Moráin, Colm

doi:10.1097/meg.0000000000000207

Cited by 26 publications

(20 citation statements)

References 35 publications

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“… 5 Positive rate of FIT ranged between 4.3% and 10.1% in previous studies. 19 – 26 The positive rate of FIT was 10.1% in a biennial FIT with postal invitations in Ireland 22 and 4.3% in a prospective cohort study in Italy. 19 In NCSP of Korea, the reported positive rates of FIT ranged between 7.1% and 7.9%, which were mixed results of qualitative and quantitative tests.…”

Section: Discussionmentioning

confidence: 93%

Quality Metrics of a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program in Korea

et al. 2018

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Background/AimsKnowledge regarding the quality metrics of fecal immunochemical test (FIT)-based colorectal cancer screening programs is limited. The aim of this study was to investigate the performance and quality metrics of a FIT-based screening program.MethodsIn our screening program, asymptomatic subjects aged ≥50 years underwent an annual FIT, and subjects with positive FIT results underwent a subsequent colonoscopy. The performance of the FIT and colonoscopy was analyzed in individuals with a positive FIT who completed the program between 2009 and 2015 at a university hospital.ResultsAmong the 51,439 screened participants, 75.1% completed the FIT. The positive rate was 1.1%, and the colonoscopy completion rate in these patients was 68.6%. The positive predictive values of cancer and advanced neoplasia were 5.5% and 19.1%, respectively. The adenoma detection rate in the patients who underwent colonoscopy after a positive FIT was 48.2% (60.0% for men and 33.6% for women). The group with the highest tertile quantitative FIT level showed a significantly higher detection rate of advanced neoplasia than the group with the lowest tertile (odds ratio, 2.6; 95% confidence interval, 1.4 to 5.1; p<0.001).ConclusionsThe quality metrics used in the United States and Europe may be directly introduced to other countries, including Korea. However, the optimal quality metrics should be established in each country.

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Section: Discussionmentioning

confidence: 93%

Quality Metrics of a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program in Korea

et al. 2018

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“…Approximately 10 000 people aged 50–74 years were identified through primary care practices and invited by mail to participate in screening; the FIT kit was sent with the initial invitation. Round 1 operated during 2008–2010 (uptake was 51%) and round 2 during 2011–2012 (uptake was 47.5%) . In both rounds, uptake was significantly lower among men than women (e.g.…”

Section: Methodsmentioning

confidence: 99%

Impact of gender on decisions to participate in faecal immunochemical test‐based colorectal cancer screening: a qualitative study

et al. 2016

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Negative attitudes and emotions to screening dominated non-user decision-making but differed by gender. Opportunities to improve uptake in men and women exist. Greater national discussions on the benefits of FIT screening, and development of screening materials tackling negative attitudes and beliefs while recognising male/female differences, may improve screening uptake. Copyright © 2016 John Wiley & Sons, Ltd.

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“…Of the patients with a positive test, 87% underwent a colonoscopy. The PPV for CRC was similar to that of the first round (4%), and the CRC detection rate was 0.12%[37]. …”

Section: Crc Screening Programsmentioning

confidence: 99%

Colorectal cancer population screening programs worldwide in 2016: An update

Navarro

Nicolas

Ferrández

et al. 2017

WJG

432

364

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Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the world. The incidence and mortality show wide geographical variations. Screening is recommended to reduce both incidence and mortality. However, there are significant differences among studies in implementation strategies and detection. This review aimed to present the results and strategies of different screening programs worldwide. We reviewed the literature on national and international screening programs published in PubMed, on web pages, and in clinical guidelines. CRC Screening programs are currently underway in most European countries, Canada, specific regions in North and South America, Asia, and Oceania. The most extensive screening strategies were based on fecal occult blood testing, and more recently, the fecal immunochemical test (FIT). Participation in screening has varied greatly among different programs. The Netherlands showed the highest participation rate (68.2%) and some areas of Canada showed the lowest (16%). Participation rates were highest among women and in programs that used the FIT test. Men exhibited the greatest number of positive results. The FIT test has been the most widely used screening program worldwide. The advent of this test has increased participation rates and the detection of positive results. Core tip: Colorectal cancer is the third most commonly diagnosed cancer worldwide. The incidence and mortality show wide geographical variations across the world. Screening is recommended to reduce both, however, there are significant differences among studies in implementation strategies and detection. This review aimed to present the results and strategies of different screening programs worldwide.

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Sustained participation, colonoscopy uptake and adenoma detection rates over two rounds of the Tallaght–Trinity College colorectal cancer screening programme with the faecal immunological test

Abstract: Repeated rounds of FIT screening in the Tallaght-Trinity College cohort achieved stable participation and neoplasia detection rates, suggesting that this mode of screening is both effective and acceptable to patients in the long term.

Cited by 26 publications

References 35 publications

Quality Metrics of a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program in Korea

Quality Metrics of a Fecal Immunochemical Test-Based Colorectal Cancer Screening Program in Korea

Impact of gender on decisions to participate in faecal immunochemical test‐based colorectal cancer screening: a qualitative study

Colorectal cancer population screening programs worldwide in 2016: An update

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