Sustained ophthalmic delivery of highly soluble drug using pH-triggered inner layer-embedded contact lens

Zhu, Qiang; Cheng, Hongbo; Huo, Yingnan; Mao, Shirui

doi:10.1016/j.ijpharm.2018.04.004

Cited by 45 publications

(33 citation statements)

References 37 publications

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“…102 A similar prototype that used a mixture of cellulose acetate and Eudragit S100 for the polymer lm with a silicone hydrogel base also showed sustained drug release under both in vivo and in vitro conditions upon pH change in tear uid. 103 Ion-triggered drug release was achieved by a silicone-based contact lens with a cellulose acetate lm embedded with betaxolol hydrochloride 104 and the drug was conjugated to poly(styrenedivinyl benzene) sulfonic acid resin. The lens could be stored in distilled water with negligible drug loss and allowed controlled release of drug for up to 1 week in rabbit model.…”

Section: Use Of Drug-polymer Lm Embedding To Contact Lensmentioning

confidence: 99%

Advances in chemistry and composition of soft materials for drug releasing contact lenses

et al. 2020

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Section: Use Of Drug-polymer Lm Embedding To Contact Lensmentioning

confidence: 99%

Advances in chemistry and composition of soft materials for drug releasing contact lenses

et al. 2020

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“…Since their first development, there has been a great deal of interest in drug delivery through CLs . To this end, a range of techniques have been used to incorporate drugs into the CL matrix including molecular imprinting, soaking in a solution with the drug, polymeric particles, ion interactions, and microemulsion loading .…”

Section: Introductionmentioning

confidence: 99%

Recent Trends in Advanced Contact Lenses

Mutlu

Es‐haghi

Çakmak

2019

Adv Healthcare Materials

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Exploiting contact lenses for ocular drug delivery is an emerging field in the area of biomedical engineering and advanced healthcare materials. Despite all the research conducted in this area, still, new technologies are in their early stages of the development, and more work must be done in terms of clinical trials to commercialize these technologies. A great challenge in using contact lenses for drug delivery is to achieve a prolonged drug release profile within the therapeutic range for various eye‐related problems and diseases. In general, desired release kinetics to avoid the initial burst release is the zero‐order kinetics within the therapeutic range. This review highlights the new technologies developed to achieve efficient and extended drug delivery. It also provides an overview of the materials and methods for fabrication of contact lenses and their mechanical and optical properties.

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“…However, frequent instillation enhances the drug concentration in the blood, and leads to poor patient compliance and systemic side effects. To resolve this conundrum and the shortcomings of traditional eye drops, the development of novel topical administration formulations and ophthalmic drug delivery systems, such as nanosuspensions, nanostructured lipid carriers, liposomes, preformed gels ( Almeida et al, 2014 ), dendrimers ion triggered release ( Zhu et al, 2018c ), ionic resin based suspension, a pH-sensitive system for drug release ( Zhu et al, 2018a , b ), ointments, bioadhesive polymers ( Silva et al, 2017 ; Grimaudo et al, 2019 ) have recently been proposed ( Gan et al, 2009 ; Shen et al, 2009 ; Hagigit et al, 2010 ; Hironaka et al, 2011 ; Sun et al, 2015 ). In particular, nanotechnology has been expected to be applied in the ophthalmic field, and many researchers have provided novel nanomedicines and nanodevices ( Sahoo and Labhasetwar, 2003 ).…”

Section: Introductionmentioning

confidence: 99%

An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva

Nagai

Minami

Deguchi

et al. 2020

Front. Bioeng. Biotechnol.

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We previously developed ophthalmic formulations containing tranilast nanopartaicles (ophthalmic TL-NPs formulations), and found them to show high uptake into ocular tissues. In this study, we aimed to design an in situ gel incorporating TL-NPs with 0.5-3% methylcellulose (MC, type SM-4) to ensure long residence time of the drug at the ocular surface. The ophthalmic TL-NPs formulations were prepared by the bead mill method, which yielded a mean particle size of˜93 nm with or without MC (0.5-3%). Although the dispersibility of TL particles in ophthalmic formulations increased with the MC content, the diffusion behavior of TL particles in the dispersion medium decreased with MC content. In an in vivo study using rats, the TL content in the lacrimal fluid was enhanced with MC content in the ophthalmic TL-NPs formulations, and the optimum amount of MC (0.5-1.5%) enhanced the TL content in the cornea and conjunctiva, and an anti-inflammatory effect of TL in rats instilled with ophthalmic TL-NPs formulations was observed. On the other hand, excessive MC (3%) prevented the corneal uptake of TL-NPs after instillation, and the anti-inflammation effect of TL was lower than that of ophthalmic TL-NPs formulations with optimum MC (0.5-1.5%). In conclusion, we found that gel formulations of TL-NPs with 0.5 and 1.5% MC provided a prolonged pre-corneal and pre-conjunctival contact time of TL, and resulted in higher TL contents in the cornea and conjunctiva following instillation in comparison with TL-NPs with or without 3% MC. This is probably due to the balance between the higher residence time and faster diffusion of TL-NPs on the ocular surface. These findings provide significant information that can be used to design further studies aimed at developing ophthalmic nanomedicines.

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Sustained ophthalmic delivery of highly soluble drug using pH-triggered inner layer-embedded contact lens

Cited by 45 publications

References 37 publications

Advances in chemistry and composition of soft materials for drug releasing contact lenses

Advances in chemistry and composition of soft materials for drug releasing contact lenses

Recent Trends in Advanced Contact Lenses

An in situ Gelling System Based on Methylcellulose and Tranilast Solid Nanoparticles Enhances Ocular Residence Time and Drug Absorption Into the Cornea and Conjunctiva

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