Sustained neurotrophic factor cotreatment enhances donor and host retinal ganglion cell survival in mice
Jonathan R. Soucy,
Emil Kriukov,
Julia Oswald
et al.
Abstract:Retinal ganglion cells (RGCs) lack regenerative capacity in mammals, and their degeneration in glaucoma leads to irreversible blindness. Traditional RGC transplantation has been limited by poor survival rates of transplanted cells in the hostile microenvironment of a diseased retina. Our research identifies brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) as key elements in retinal development and RGC survival through in silico analysis of the single-cell transcriptome of d… Show more
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