Sustained Negative BOLD, Blood Flow and Oxygen Consumption Response and Its Coupling to the Positive Response in the Human Brain

Shmuel, Amir; Yacoub, Essa; Pfeuffer, Josef; Moortele, Pierre-François Van de; Adriany, Gregor; Hu, Xiaoping; Uğurbil, Kâmil

doi:10.1016/s0896-6273(02)01061-9

Cited by 572 publications

(511 citation statements)

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“…The deactivation found in our experiment could therefore be caused by such an attention demand (i.e. 'vascular steal'; [49]) resulting from observing the video sequences on screen.…”

Section: Discussionmentioning

confidence: 74%

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

Vögeli¹,

Wolf²,

Wechsler

et al. 2015

Behavioural Brain Research

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Mood, as a long-term affective state, is thought to modulate short-term emotional reactions in animals, but the details of this interplay have hardly been investigated experimentally. Apart from a basic interest in this affective system, mood is likely to have an important impact on animal welfare, as bad mood may taint all emotional experience. In the present study about mood -emotion interaction, 29 sheep were kept under predictable, stimulus-rich or unpredictable, stimulus-poor housing conditions, to induce different mood states. In an experiment, the animals were confronted with video sequences of social interactions of conspecifics showing agonistic interactions, ruminating or tolerantly co-feeding as stimuli of different valences. Emotional reactions were assessed by measuring frontal brain activity using functional near-infrared spectroscopy and by recording behavioral reactions. Attentiveness of the sheep decreased from videos showing agonistic interactions toruminating sheep to those displaying co-feeding sheep. Seeing agonistic interactions was also associated with a deactivation of the frontal cortex, specifically in animals living under predictable, stimulus-rich housing conditions. These sheep generally showed less attentiveness and locomotor activity and they had their ears in a forward position less often and in a backward position more often than the sheep from the unpredictable, stimulus-poor conditions. Housing conditions influenced how the sheep behaved, which can either be thought to be mediated by mood or by the animals' previous experience with stimulusrichness in their housing conditions. Frontal cortical activity may not depend on valence only, but also on the perceptual channel through which the stimuli were perceived.

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“…The deactivation found in our experiment could therefore be caused by such an attention demand (i.e. 'vascular steal'; [49]) resulting from observing the video sequences on screen.…”

Section: Discussionmentioning

confidence: 74%

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

Vögeli¹,

Wolf²,

Wechsler

et al. 2015

Behavioural Brain Research

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“…A specific aspect of BOLD contrast where there is continuing controversy on the interpretation of fMRI data is the existence of negative BOLD and its link with neural activity Shmuel et al, 2002;Devor et al, 2007;Northoff et al, 2007;Schridde et al, 2008;Woolsey et al, 1996). In the first paper of this series, Woolsey et al (1996) studied the links between neuronal units and micro-vascular modules in cerebral cortex of the rodent whiskerbarrel system.…”

Section: Hemodynamic Variations Induced By Local Vasodilationsmentioning

confidence: 99%

Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network. Part II: Flow variations induced by global or localized modifications of arteriolar diameters

Lorthois¹,

Cassot²,

Lauwers³

2011

NeuroImage

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. In a companion paper (Lorthois et al., Neuroimage, in press), we perform the first simulations of blood flow in an anatomically accurate large human intra-cortical vascular network (~10000 segments), using a 1D non-linear model taking into account the complex rheological properties of blood flow in microcirculation. This model predicts blood pressure, blood flow and hematocrit distributions, volumes of functional vascular territories, regional flow at voxel and network scales, etc. Using the same approach, we study flow reorganizations induced by global arteriolar vasodilations (an isometabolic global increase in cerebral blood flow). For small to moderate global vasodilations, the relationship between changes in volume and changes in flow is in close agreement with Grubb's law, providing a quantitative tool for studying the variations of its exponent with underlying vascular architecture. A significant correlation between blood flow and vascular structure at the voxel scale, practically unchanged with respect to baseline, is demonstrated. Furthermore, the effects of localized arteriolar vasodilations, representative of a local increase in metabolic demand, are analyzed. In particular, localized vasodilations induce flow changes, including vascular steal, in the neighboring arteriolar trunks at small distances (b 300 μm), while their influence in the neighboring veins is much larger (about 1 mm), which provides an estimate of the vascular point spread function. More generally, for the first time, the hemodynamic component of various functional neuroimaging techniques has been isolated from metabolic and neuronal components, and a direct relationship with several known characteristics of the BOLD signal has been demonstrated. IntroductionThere is increasing recognition that, by its structural implication in neuro-vascular coupling, underlying vascular architecture is a key player in hemodynamically based functional imaging techniques (including fMRI and PET) (Harrison et al., 2002;d'Esposito et al., 2003;Logothetis and Wandell, 2004;Lauwers et al., 2008;Weber et al., 2008). In particular, the spatial resolution and specificity of such techniques are bound to the density of blood capillary vasculature and blood flow regulating structures (Harel et al., 2006). This is especially important in the context of high field fMRI Harel et al., 2006), because, despite a dramatic increase in the theoretical spatial resolution obtained by using higher magnetic fields, associated with other hardware advancements, "the spatial extent of the hemodynamic response ultimately will impose a fundamental limitation on the spatial resolution of fMRI modalities" ).However, little is known about the fundamentals of the relationship between vascular structure and hemodynamic changes induced by brain activation. A growing body of evidence indicates that neurons, glia, and cerebral blood vessels, actin...

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“…Recent studies have provided evidence of a neural component to the inhibitory rebound. Shmuel et al (2006Shmuel et al ( , 2002 have studied the origin of the negative BOLD activation in cortical regions adjacent to those receiving direct projections from stimulated retina and shown that it cannot be attributed to blood dynamics but must be a result of a reduction in the neuronal signal in those regions. Such studies imply that it is reasonable to attribute negative BOLD signals to inhibitory suppression of neural activity, especially in the present situation when (1) there is no diVerence in the local stimulation between the test-and the null-epochs, (2) and the only sites of activation are remote from the zone of reduced BOLD response.…”

Section: Analysis: a Recurrent Wgure/ground Modelmentioning

confidence: 99%

Occipital network for figure/ground organization

Likova

Tyler

2008

Exp Brain Res

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This is the accepted version of the paper.This version of the publication may differ from the final published version. Abstract To study the cortical mechanism of Wgure/ ground categorization in the human brain, we employed fMRI and the temporal-asynchrony paradigm. This paradigm is able to eliminate any diVerential activation for local stimulus features, and thus to identify only global perceptual interactions. Strong segmentation of the image into diVerent spatial conWgurations was generated solely from temporal asynchronies between zones of homogeneous dynamic noise. The Wgure/ground conWguration was a single geometric Wgure enclosed in a larger surround region. In a control condition, the Wgure/ground organization was eliminated by segmenting the noise Weld into many identical temporal-asynchrony stripes. The manipulation of the type of perceptual organization triggered dramatic reorganization in the cortical activation pattern. The Wgure/ground conWguration generated suppression of the ground representation (limited to early retinotopic visual cortex, V1 and V2) and strong activation in the motion complex hMT+/ V5+; conversely, both responses were abolished when the Wgure/ground organization was eliminated. These results suggest that Wgure/ground processing is mediated by topdown suppression of the ground representation in the earliest visual areas V1/V2 through a signal arising in the motion complex. We propose a model of a recurrent cortical architecture incorporating suppressive feedback that operates in a topographic manner, forming a Wgure/ground categorization network distinct from that for "pure" scene segmentation and thus underlying the perceptual organization of dynamic scenes into cognitively relevant components. Permanent repository link

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Sustained Negative BOLD, Blood Flow and Oxygen Consumption Response and Its Coupling to the Positive Response in the Human Brain

Cited by 572 publications

References 49 publications

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

Housing conditions influence cortical and behavioural reactions of sheep in response to videos showing social interactions of different valence

Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network. Part II: Flow variations induced by global or localized modifications of arteriolar diameters

Occipital network for figure/ground organization

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