Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury and repair

Hanwright, Philip J.; Qiu, Chenhu; Rath, Jennifer; Zhou, Yang; Guionneau, Nicholas von; Sarhane, Karim A.; Harris, Thomas K.; Howard, Gregory P.; Malapati, Harsha; Lan, Michael J.; Reddy, Sashank K.; Höke, Ahmet; Mao, Hai‐Quan; Tuffaha, Sami H.

doi:10.1016/j.biomaterials.2021.121244

Cited by 31 publications

(25 citation statements)

References 54 publications

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“…IGF-1 is a polypeptide hormone mainly secreted by hepatocytes, it participates in a variety of physiological activities in the body, such as promoting the repair of injured peripheral nerves [15] , increasing the density of bone minerals to prevent fractures [16] and regulating brain development. The GH-IGF-1 axis can stimulate the proliferation of chondrocytes on the growth plate, which plays a decisive role in regulating human linear growth [17] .…”

Section: Discussionmentioning

confidence: 99%

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Liu

Cheng

Sun

et al. 2023

Preprint

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Purpose: This study explored the early warning value of serum insulin-like growth factor-1(IGF-1), fibroblast growth factor 23(FGF23), and Klotho levels in girls with rapidly progressive central precocious puberty (RP-CPP). Method: This is a prospective cohort study on the progression rate of central precocious puberty in girls, who complained of breast development before the age of 8 years and were followed between June 2021and June 2022. At the same time, 28 healthy girls less than 8 years old who had not started puberty were recruited as the control group. The physical examination and laboratory evaluation of each group was completed. Only patients with CPP received pelvic ultrasound examination and bone age test. The ROC curve was used to judge the warning value. Results: Bone age index (BAI), basal LH levels (BLH), basal LH levels / basal FSH levels (BFSH), peak LH (PLH) / peak FSH (PFSH), IGF-1, Klotho, FGF23 and ovarian volume in RP-CPP group were higher than those in slowly progressive CPP (SP-CPP) group. In the RP-CPP group, IGF-1 was correlated with Klotho, FGF23, and BLH; Klotho was correlated with FGF23 and BLH; FGF23 was correlated with BLH. The AUC of BLH, Klotho, and IGF-1 were 0.931,0.829 and 0.809, respectively. The AUC was the largest when BLH and Klotho were combined. Conclusions: The BLH, Klotho, and IGF-1 have early warning effects on RP-CPP. The binding analysis improves the effectiveness of diagnosis.

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Section: Discussionmentioning

confidence: 99%

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Liu

Cheng

Sun

et al. 2023

Preprint

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“…Recent PNI studies are focusing on nanoparticle‐based therapeutics instead of structural support using nerve constructs. One such strategy is to deliver insulin‐like growth factor (IGF‐1; Hanwright et al, 2022) and nitric oxide (NO; Lee et al, 2022) to PNI sites. IGF‐1 is a growth factor that protects neurons, myocytes, and SCs from apoptosis.…”

Section: Nanoparticlesmentioning

confidence: 99%

Bioengineering approaches for nerve graft revascularization: Current concepts and future directions

Pereira

Lazar

Wang

2023

WIREs Mechanisms of Disease

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Peripheral nerve injury (PNI) is the most common neurological injury in civilian and military injuries, with over 360,000 PNI procedures performed in the US yearly. Segmental loss of nerve tissue results in a nerve gap precluding a tension-free primary repair, and in these cases, interpositional autologous or acellular nerve allografts are used to bridge the gap. Graft ischemia time is a critical factor in achieving satisfactory nerve regeneration. Rapid nerve graft revascularization is essential in order to sustain Schwann cell growth which in turn is crucial for axonal regeneration. Currently, nerve autografts are considered the gold standard for segmental nerve gaps but are associated with several disadvan-

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“…Improved functional recovery has been seen through the provision of GH in a rat model of chronic denervation, although it is unclear, the mechanism of these benefits and changes in rSC markers was not fully examined [ 75 ]. Hanwright et al [ 76 ] utilised a hydrogel, releasing IGF-1 in a rat model of chronic nerve degeneration. This intervention maintained SC proliferation in chronic denervation and improved the functional outcomes of nerve regeneration [ 76 ].…”

Section: The Chronically Denervated Sc As a Therapeutic Targetmentioning

confidence: 99%

“…Hanwright et al [ 76 ] utilised a hydrogel, releasing IGF-1 in a rat model of chronic nerve degeneration. This intervention maintained SC proliferation in chronic denervation and improved the functional outcomes of nerve regeneration [ 76 ]. The interplay between GH and c-Jun activation in SC has not been established, although in other models IGF-1 is known to stimulate c-Jun [ 77 ].…”

Section: The Chronically Denervated Sc As a Therapeutic Targetmentioning

confidence: 99%

Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?

et al. 2022

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Outcomes for patients following major peripheral nerve injury are extremely poor. Despite advanced microsurgical techniques, the recovery of function is limited by an inherently slow rate of axonal regeneration. In particular, a time-dependent deterioration in the ability of the distal stump to support axonal growth is a major determinant to the failure of reinnervation. Schwann cells (SC) are crucial in the orchestration of nerve regeneration; their plasticity permits the adoption of a repair phenotype following nerve injury. The repair SC modulates the initial immune response, directs myelin clearance, provides neurotrophic support and remodels the distal nerve. These functions are critical for regeneration; yet the repair phenotype is unstable in the setting of chronic denervation. This phenotypic instability accounts for the deteriorating regenerative support offered by the distal nerve stump. Over the past 10 years, our understanding of the cellular machinery behind this repair phenotype, in particular the role of c-Jun, has increased exponentially, creating opportunities for therapeutic intervention. This review will cover the activation of the repair phenotype in SC, the effects of chronic denervation on SC and current strategies to ‘hack’ these cellular pathways toward supporting more prolonged periods of neural regeneration.

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Sustained IGF-1 delivery ameliorates effects of chronic denervation and improves functional recovery after peripheral nerve injury and repair

Cited by 31 publications

References 54 publications

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Early diagnostic value of serum IGF-1, FGF23 and Klotho in girls with rapidly progressive central precocious puberty

Bioengineering approaches for nerve graft revascularization: Current concepts and future directions

Advancing Our Understanding of the Chronically Denervated Schwann Cell: A Potential Therapeutic Target?

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