Sustained fever associated with immune checkpoint inhibitors may be a poor prognostic factor

Ueda, Hiroki; Murakami, Eriko; Okuda, Yuka; Takase, Eri; Kaki, Takahiro; Harutani, Yuhei; Yamagata, Nao; Furuta, Katsuyuki; Shimono, Chigusa; Yamamoto, Nobuyuki

doi:10.1093/annonc/mdz338.109

Cited by 3 publications

(3 citation statements)

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“…In addition, a variety of diseases such as tumors, stroke, neurodegenerative diseases, sepsis and so on show fever symptoms, so it is very important to detect fever in the development of various diseases. 113,114 However, only a few of these diseases have studied the temperature changes at the tissue and cell level. Most of them still focus on the detection of core temperature and have not yet studied in depth.…”

Section: Diseases Diagnosis and Treatmentmentioning

confidence: 99%

“…Among patients, body temperature below 36.5 ˚C was dramatically related to an elevated risk of death, more than twice as high as in patients with non‐hypothermia. In addition, a variety of diseases such as tumors, stroke, neurodegenerative diseases, sepsis and so on show fever symptoms, so it is very important to detect fever in the development of various diseases 113,114 . However, only a few of these diseases have studied the temperature changes at the tissue and cell level.…”

Section: Applicationsmentioning

confidence: 99%

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Nanothermometry for cellular temperature monitoring and disease diagnostics

Liu,

Sun,

Teh

et al. 2024

Interdisciplinary Medicine

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Body temperature variations, including the generation, transfer, and dissipation of heat, play an important role throughout life and participate in all biological events. Cellular temperature information is an indispensable link in the comprehensive understanding of life science processes, but traditional testing strategies cannot provide sufficient information due to their low precision and inefficient cellular‐entrance. In recent years, with the help of luminescent nanomaterials, a variety of new thermometers have been developed to achieve real‐time temperature measurement at the micro/nano scale. In this review, we summarized the latest advances in several nanoparticles for cellular temperature detection and their related applications in revealing cell metabolism and disease diagnosis. Furthermore, this review proposed a few challenges for the nano‐thermometry, expecting to spark novel thought to push forward its preclinical and translational uses.

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Section: Diseases Diagnosis and Treatmentmentioning

confidence: 99%

Section: Applicationsmentioning

confidence: 99%

Nanothermometry for cellular temperature monitoring and disease diagnostics

Liu,

Sun,

Teh

et al. 2024

Interdisciplinary Medicine

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“…For instance, during tumour growth, signalling regulated by the PD-1/PD-L1 pathway is also associated with substantial inflammatory effects ( 6 ). As such, sustained fever associated with anti PD-1 mAb monotherapy appears to be a poor prognostic factor for patients ( 7 ). Further, inflammation can promote resistance to ICI in some cancer models ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

ThermoPCD: a database of molecular dynamics trajectories of antibody–antigen complexes at physiologic and fever-range temperatures

Singh,

Stan

2024

Database

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Progression of various cancers and autoimmune diseases is associated with changes in systemic or local tissue temperatures, which may impact current therapies. The role of fever and acute inflammation-range temperatures on the stability and activity of antibodies relevant for cancers and autoimmunity is unknown. To produce molecular dynamics (MD) trajectories of immune complexes at relevant temperatures, we used the Research Collaboratory for Structural Bioinformatics (RCSB) database to identify 50 antibody:antigen complexes of interest, in addition to single antibodies and antigens, and deployed Groningen Machine for Chemical Simulations (GROMACS) to prepare and run the structures at different temperatures for 100–500 ns, in single or multiple random seeds. MD trajectories are freely available. Processed data include Protein Data Bank outputs for all files obtained every 50 ns, and free binding energy calculations for some of the immune complexes. Protocols for using the data are also available. Individual datasets contain unique DOIs. We created a web interface, ThermoPCD, as a platform to explore the data. The outputs of ThermoPCD allow the users to relate thermally-dependent changes in epitopes:paratopes interfaces to their free binding energies, or against own experimentally derived binding affinities. ThermoPCD is a free to use database of immune complexes’ trajectories at different temperatures that does not require registration and allows for all the data to be available for download. Database URL: https://sites.google.com/view/thermopcd/home

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