Sustained Drug Delivery Systems II: Factors Affecting Release Rates from Poly(ε-caprolactone) and Related Biodegradable Polyesters

Pitt, Colin G.; Gratzl, Margit M.; Jeffcoat, A; Zweidinger, Roy B.; Schindler, A.

doi:10.1002/jps.2600681219

Cited by 201 publications

(59 citation statements)

References 11 publications

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“…PCL is another important member of synthetic biodegradable polymer family. It is linear, hydrophobic, partially crystalline polyester, and can be slowly degraded by microbes [27][28][29]. Blends between starch and PCL have been well documented in the literatures [30][31][32][33][34][35].…”

Section: Physical Blends 311 Blend With Synthetic Degradable Polymersmentioning

confidence: 99%

Starch-based completely biodegradable polymer materials

Lu¹,

Xiao²,

Xu³

2009

Express Polym. Lett.

635

320

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Abstract. Starch is a natural polymer which possesses many unique properties and some shortcoming simultaneously. Some synthetic polymers are biodegradable and can be tailor-made easily. Therefore, by combining the individual advantages of starch and synthetic polymers, starch-based completely biodegradable polymers (SCBP) are potential for applications in biomedical and environmental fields. Therefore it received great attention and was extensively investigated. In this paper, the structure and characteristics of starch and some synthetic degradable polymers are briefly introduced. Then, the recent progress about the preparation of SCBP via physical blending and chemical modification is reviewed and discussed. At last, some examples have been presented to elucidate that SCBP are promising materials for various applications and their development is a good solution for reducing the consumption of petroleum resources and environmental problem.

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Section: Physical Blends 311 Blend With Synthetic Degradable Polymersmentioning

confidence: 99%

Starch-based completely biodegradable polymer materials

Lu¹,

Xiao²,

Xu³

2009

Express Polym. Lett.

635

320

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“…Among United States Food and Drug Administration (FDA)-approved polyesters, poly(ɛ-caprolactone) (PCL) possesses unique properties such as enhanced biocompatibility, higher hydrophobicity, and neutral biodegradation end products that do not disturb the pH balance of the degradation medium (9)(10)(11)(12)(13). Over the years, an array of drug delivery systems has been developed using PCL (14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Introductionmentioning

confidence: 99%

Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies

et al. 2005

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Purpose.-This study was carried out to determine the biodistribution profiles and tumor localization potential of poly(ethylene oxide) (PEO)-modified poly (β-amino ester) (PbAE) as a novel, pH-sensitive biodegradable polymeric nanoparticulate system for tumor-targeted drug delivery.Methods.-The biodistribution studies of PEO-modified PbAE and PEO-modified poly(ɛ-caplactone) (PCL), a non-pH sensitive polymer, nanoparticle systems were carried out in normal mice using 111 indiumoxine [ 111 In] as a lipophilic radiolabel encapsulated within the polymeric matrix and the distribution of the nanoparticles was studied in plasma and all the vital organs following intravenous administration. Solid tumors were developed on nude mice using human ovarian carcinoma xenograft (SKOV-3) and the change in concentrations of tritium [ 3 H]-labeled paclitaxel encapsulated in polymeric nanoparticles was examined in blood, tumor mass and liver.Results.-Study in normal mice with a gamma-emitting isotope [ 111 In] provided a thorough biodistribution analysis of the PEO-modified nanoparticulate carrier systems, while the 3 H-paclitaxel was useful to understand the change in concentration and tumor localization of anticancer compound directly in major sites of distribution. Both PEO-PbAE and PEO-PCL nanoparticles showed long systemic circulating properties by virtue of surface modification with PEO-containing triblock block copolymer (Pluronic ® ) stabilizer. While the PCL nanoparticles showed higher uptake by the reticuloendothelial system (RES), the PbAE nanoparticles effectively delivered the encapsulated payload into the tumor mass.Conclusions.-PEO-modified PbAE nanoparticles showed considerable passive tumor targeting potential in early stages of biodistribution via the enhanced permeation and retention (EPR) mechanism. This prompts a detailed biodistribution profiling of the nanocarrier for prolonged periods of time to provide conclusive evidence for superiority of the delivery system.

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“…For the case of drug delivery systems, therapeutic agents have been formulated into PLGA microspheres, disks, and rods. [2][3][4] Drug release from these PLGA matrices is governed by both diffusion of the drug 1,5 and degradation of the polymer. [5][6][7] The major mechanism of PLGA degradation under physiologic conditions is hydrolysis.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4] Drug release from these PLGA matrices is governed by both diffusion of the drug 1,5 and degradation of the polymer. [5][6][7] The major mechanism of PLGA degradation under physiologic conditions is hydrolysis. 8 Thus, water penetration into PLGA devices is a key factor in determining the overall rate of polymer degradation, and hence, the rate of release of the therapeutic agents from a PLGA delivery system.…”

Section: Introductionmentioning

confidence: 99%

Effects of metal salts on poly(DL-lactide-co-glycolide) polymer hydrolysis

Zhang

Zale

Sawyer

et al. 1997

J. Biomed. Mater. Res.

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The effects of encapsulated metal salts on poly(DL-lactide-co-glycolide) (PLGA) water uptake and degradation properties were investigated in this work. Salts of varying aqueous solubility characteristics were incorporated into PLGA films either as particles or by codissolution in polymer solutions. Polymer films were characterized with respect to the kinetics of water uptake, morphology changes, degradation, and weight loss after hydration. It was found that these properties are strongly influenced by the presence and nature of encapsulated salts. Effects range from minor changes in water uptake profile with no significant difference in degradation kinetics to major alterations in water uptake kinetics together with a several-fold decrease in the polymer degradation rate. Possible mechanistic explanations for the observed effects are discussed.

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Sustained Drug Delivery Systems II: Factors Affecting Release Rates from Poly(ε-caprolactone) and Related Biodegradable Polyesters

Cited by 201 publications

References 11 publications

Starch-based completely biodegradable polymer materials

Starch-based completely biodegradable polymer materials

Poly(Ethylene Oxide)-Modified Poly(β-Amino Ester) Nanoparticles as a pH-Sensitive System for Tumor-Targeted Delivery of Hydrophobic Drugs: Part 2. In Vivo Distribution and Tumor Localization Studies

Effects of metal salts on poly(DL-lactide-co-glycolide) polymer hydrolysis

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